Sleep and repair of DNA breaks across evolution
Speaker: Professor Lior Appelbaum
The Mina & Everard Goodman Faculty of Life Sciences and the Multidisciplinary Brain Research Center
Bar Ilan University
Israel
Title: Sleep and repair of DNA breaks across evolution
Abstract: Sleep is vital for survival of all animals, ranging from jellyfish to fish and humans. Sleep improves brain performance, such as memory and learning, however, even invertebrates with simple nervous system sleep, and the core cellular function of this enigmatic behavior is unclear. We propose that single neuron, located within intact networks, requires sleep across evolution. We combine imaging of DNA damage response proteins, CRISPER-mediated genetic manipulations, real time imaging of neuronal activity, as well as video tracking of behavior to study the interaction between sleep, neuronal activity, DNA damage and repair in cnidarian and fish. We suggest that sleep upregulates nuclear maintenance in neurons of both invertebrates and vertebrates.
About Neuroscience Seminars
Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.
Seminars in the QBI Auditorium on Level 7 are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details.
