Translational research: How to deal with the uncertainty of what Alzheimer's disease actually is
Speaker: Professor Jürgen Götz
Queensland Brain Institute
University of Queensland
Title: Translational research: How to deal with the uncertainty of what Alzheimer's disease actually is
Abstract: The troubling FDA approval of the anti-amyloid drug aducanumab illustrates the challenges about defining what Alzheimer’s disease actually is - is it one disease or many, what are the key molecules which need to be targeted, are we dealing with a cellular or a brain network problem and to which extent is preclinical animal research informative? These questions are critical as the diagnosis of Alzheimer’s disease moves from determining cognitive read-outs to biomarkers. I will begin my presentation with an overview of some of these questions and use them to provide an update of my team’s research which includes pathomechanistic work around tau, the discovery of proteostasis as a fundamental principle of tau immunotherapy, and preclinical and clinical studies using low-intensity ultrasound as a treatment modality for complex diseases of the brain including Alzheimer’s diseases.
About Neuroscience Seminars
Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.
Seminars in the QBI Auditorium on Level 7 are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details.
