Mechanisms of neural network aging: insights from C. elegans
Speaker: Dr Zhaoyu Li
Queensland Brain Institute
University of Queensland
Title: Mechanisms of neural network aging: insights from C. elegans
Abstract: Brain aging gives rise to a series of motor and cognitive behaviour declines and is the major risk factor for many neurological diseases such as Alzheimer's disease (AD). Though important, it remains poorly understood of how brain functions change with aging, and how these processes can be prevented by genetic and pharmacological interventions. We use C. elegans to address these questions. By combining quantitative behavioual analysis, whole brain calcium imaging, and mathematical modelling, we found that motor decline during aging is associated with the impairment of neural network states, and this process can be modelled using attractor theory. Interestingly, impairment of neural circuit also triggers compensatory neural activities and behaviours during aging. Drugs that extend lifespan preserves neural network function.
About Neuroscience Seminars
Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.
Seminars in the QBI Auditorium on Level 7 are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details.
