Professor Etienne Sibille
Campbell Family Mental Health Research Institute

Chair and Senior Scientist, Campbell Family Mental Health Research Institute of CAMH, Toronto, ON, Canada,

Professor, Departments of Psychiatry and, of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada

Title: GABA and Cognitive Deficits in Depression and Aging: Origins, Mechanisms and Therapeutics

Changes in the brain excitation inhibition balance characterize neuropsychiatric disorders and aging. Using human post-mortem samples and genetic rodent models, combined with genomic and bioinformatics approaches, we have reported changes in GABAergic inhibitory neurons that target pyramidal cell dendrites in human depression and aging, and associated these changes with cognitive and mood behaviors in rodent models. Using molecular modeling, medicinal chemistry, pharmacological approaches and rodent behavioral models, we now show that novel molecules that activate alpha5-containing GABA-A receptor, which mediate the function of dendritic-targeting GABAergic neurons, show robust pro-cognitive, anxiolytic and antidepressant effects in adult and age mice. Collectively the results suggest a novel therapeutic approach for the unmet need of reducing cognitive symptoms across brain disorders.

About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

Seminars in the QBI Auditorium on Level 7 are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details. 


Neuroscience Seminars archive 2005-2018