Dr Lena Oestreich
Centre for Clinical Research
University of Queensland

Title: Post-stroke depression: vulnerability, mechanisms, and novel treatment targets

Post-stroke depression is one of the most common complications of stroke, affecting over one-third of stroke survivors and adversely influencing rehabilitation outcomes. Due to the delayed onset of post-stroke depression approximately 3 months after infarct and a poor understanding of brain-based mechanisms underlying these symptoms, acute care is currently unable to identify individuals at-risk and offer preventative treatment strategies. This talk will focus on our key research areas, aimed at developing mechanistic models of post-stroke depression, which will inform new treatment targets for preventative interventions. To achieve this, we (1) combine advanced neuroimaging approaches to pinpoint brain areas associated with depressive symptoms that are particularly vulnerable to the effects of ischemic events, (2) utilize and develop computational neuroscience approaches to map the diffuse effects of remote lesions on localized brain structure and function, and (3) establish the relative importance of neurobiological and clinical factors to the symptom burden of post-stroke depression.

About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

Seminars in the QBI Auditorium are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details. 


Neuroscience Seminars archive 2005-2018