Speaker: Dr Susannah Tye

Title: Precision Medicine Pathways for Treatment Resistant Depression


Depression is a disabling and difficult to treat disease with significant morbidity and mortality. Inflammation and metabolic dysfunction are associated with treatment-resistant depression (TRD), but the mechanisms underlying this relationship are not fully understood. Low doses of ketamine can rapidly shift the depressive state in a subset of patients with TRD, offering new insight into biological contributors to antidepressant resistance, response, and suicidal ideation. Our recent data suggests the interplay between metabolism, immune function and neurotrophic signalling may moderate therapeutic outcomes and contribute to key symptoms of depression when inflammatory load is high and metabolic resources are depleted. The role of downstream mTOR signalling as a master regulator of immune function, cellular metabolism, and plasticity will be presented, and phenotypic predictors associated with biological correlates of ketamine response will also be discussed. Quantifying targetable immunometabolic responses, including insulin signalling, cellular energetics, and immune system function, at the level of the individual patient has the potential to improve clinical outcomes in TRD, and highlights novel therapeutic targets and new opportunities for precision psychiatry.


About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

Seminars in the QBI Auditorium are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details. 


Neuroscience Seminars archive 2005-2018