Speaker: Dr Nigel Kee

Title: Derivation of Posterior Axial Assembloids (PAXAs) from human stem cells

Nigel's research combines developmental biology with in vitro human pluripotent stem cell technologies to model and test how stem cells can be instructed to build the different tissues of our bodies. These models can be used to understand basic principles of how stem cells make lineage specification decisions, or as platforms to study human diseases. Nigel earned his BSc at the University of QLD, before relocating to Karolinska Institutet in Stockholm for his PhD. Here, he trained in the then-emerging field of single-cell RNA-sequencing to guide the refinement of stem cell protocols targeting Parkinson’s disease. During his subsequent postdoc Nigel was awarded two back-to-back fellowships, supporting his appointments at Karolinska Institutet and Stockholm University, where he developed new 3D assembloid models of posterior body axis development. These floating posterior mini-tissues comprise a heterogeneous mix of cell types, and have been designed to aid modelling of neuromuscular disorders such as muscular dystrophies, peripheral neuropathies, and motor neuron disease. His future research is focused upon establishing new complex human stem cell models of posterior axis development, including refinement of AP-patterning and the derivation of novel posterior tissues.


Host: Dr Adam Walker


About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

Seminars in the QBI Auditorium on Level 7 are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details. 


Neuroscience Seminars archive 2005-2018