Assistant Professor Ben Sivyer
Casey Eye Institute, Oregon Health & Science University
Portland, Oregon, USA

Title: Retinal ganglion cells underlying non-image forming vision

The visual system is critical for navigation of the environment and underlies the detection and recognition of objects such as predators or prey, or the location of food. Many neurons in the retina however, underlie non-image forming vision such as image stabilization, pupil reflex, and homeostatic functions such as circadian entrainment and the regulation of body temperature. We use genetic approaches, confocal microscopy, multielectrode array recordings, and optogenetics to identify subtypes of intrinsically photosensitive retinal ganglion cells (ipRGCs), a specialized class of photoreceptors that contain their own photopigment, melanopsin. We show a subtype of ipRGCs restricted to the dorsal retina that selectively projects to the supraoptic nucleus, a region involved in the release of oxytocin and vasopressin. These ipRGCs tile a dorsal region of the retina, forming a substrate for encoding ground luminance. Our results provide a framework for the functional diversity of ipRGCs in the retina and suggests non-image forming visual processing samples local regions of visual space to influence diverse behaviors.


About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

Seminars in the QBI Auditorium are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details. 


Neuroscience Seminars archive 2005-2018