A/Professor Irina Voineagu
School of Biotechnology and Biomolecular Sciences
The University of New South Wales, 
Sydney NSW

Title: Gene expression regulation in the brain in health and disease


Behavioral and neuropsychiatric traits are genetically complex and associated primarily with non-coding variants located in regulatory regions that control gene expression. Thousands of candidate distal regulatory regions have been mapped in human brain tissue based on biochemical properties such as open chromatin state and chromatin post-translational modifications. However, the functional validation of these candidate regions and linking enhancers to their target genes remains challenging. This talk will discuss our recent high-throughput CRISPRi screen of enhancers in human glial cells, and novel evidence for the role of a transcriptional regulator of enhancer activity in intellectual disability. 

About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

Seminars in the QBI Auditorium on Level 7 are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details. 


Neuroscience Seminars archive 2005-2018