Dr Sarah Gordon

Head, Presynaptic Physiology Laboratory

The Florey Institute of Neuroscience and Mental Health

The University of Melbourne

Title: "Presynaptic Dysfunction in Neurological Disease"


The revolution in genetic technology has ushered in a new age for our understanding of the underlying causes of neurodevelopmental, neuromuscular and neurodegenerative disorders, revealing that the presynaptic machinery governing synaptic vesicle dynamics is compromised in many of these neurological disorders. Neuronal communication relies on the tightly controlled fusion and recycling of synaptic vesicles at nerve terminals, resulting in the release of neurotransmitters with strict temporal and quantal precision. These processes are under exquisite regulatory control to ensure high-fidelity neuronal communication, and perturbation of this regulation can lead to a breakdown in neurotransmission. In this talk, I will discuss how disruption to a variety of presynaptic processes may contribute to dysfunctional neurotransmission and thus neurological disease.



About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

Seminars in the QBI Auditorium are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details. 


Neuroscience Seminars archive 2005-2018