Professor S. Thomas Carmichael

Department of Neurology, David Geffen School of Medicine at UCLA

Title: "Smart Mice to Smart Humans: 5 stories from discovery science to clinical trials in stroke recovery"


The brain has limited spontaneous recovery from stroke. The mechanisms of spontaneous recovery in stroke resemble those described in learning and memory, including at the neuropsychological, brain imaging, cellular and molecular levels. We hypothesized that molecular systems that are active in learning and memory may play a role in neuroplasticity during recovery in stroke. further, molecular memory systems may be druggable targets to enhance recovery in stroke. This talk will present data from studies of recovery processes in stroke in tonic GABA signaling, CREB and CCR5 manipulations and in PDE isoform-specific inhibitors. Several biological principles that come from this work that relate to larger concepts of brain injury and repair will be discussed.



About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

Seminars in the QBI Auditorium on Level 7 are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details. 


Neuroscience Seminars archive 2005-2018