Professor Magdalena Götz, Germany : "Novel mechanisms of neurogenesis and neural repair"
Speaker:
Professor Magdalena Götz
Biomedical Center, University of Munich and Institute for Stem Cell Research, Helmholtz Center, Munich, Germany
Title: "Novel mechanisms of neurogenesis and neural repair"
Abstract:
We study the mechanisms of neurogenesis in order to implement them for neuronal repair. I will present recent work on a novel centrosomal protein, Akna, regulated with great precision in subsets of neural stem cells. This led us to unravel an unprecedented centrosome heterogeneity in human neural stem cells revealing and verifying novel disease candidates. I will proceed to present recent data on a master regulator of nuclear compartmentalization by liquid phase transition with key roles in promoting neural stem cell self-renewal and neurogenesis. Interestingly, Trnp1 is also critical for direct neuronal reprogramming which leads to discuss recent progress in direct neuronal reprogramming as a means to replace lost neurons after brain injury. If time allows the presentation will be concluded by discussing the integration of replaced neurons into the circuitry of the murine cerebral cortex and present unpublished data about the mechanisms regulating this integration. Taken together, our knowledge about basic mechanisms of neurogenesis allowed making great strides towards neuronal repair.
About Neuroscience Seminars
Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.
Seminars in the QBI Auditorium are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details.
