Professor David Bredt

Johnson and Johnson San Diego R&D Site Leader Global Head Discovery Neuroscience

San Diego, California, United States 

Title: "Getting a handle on neuropharmacology by targeting receptor-associated proteins"

Abstract: Targeted therapy for neuropsychiatric disorders requires selective modulation of dysfunctional neuronal pathways. Receptors relevant to CNS disorders typically have associated proteins discretely expressed in specific neuronal pathways; these accessory proteins provide a new dimension for drug discovery.  Recent studies show that targeting a TARP auxiliary subunit of AMPA receptors selectively modulates neuronal excitability in specific forebrain pathways relevant to epilepsy.  Other medicinally-important ion channels, gated by glutamate, GABA and acetylcholine also have associated proteins, which may be druggable.  This emerging pharmacology of receptor-associated proteins provides a new approach for improving drug efficacy while mitigating side effects.


About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

Seminars in the QBI Auditorium on Level 7 are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details. 


Neuroscience Seminars archive 2005-2018