Synaptic Plasticity

The Sah laboratory uses electrophysiology and molecular techniques, in conjunction with behavioural studies, to understand the neural circuitry that underpins learning and memory formation. Using animal models, the laboratory focusses on the part of the brain called the amygdala, and a Pavlovian learning paradigm called fear conditioning. The group uses viruses to deliver optogenetic constructs to neurons in defined regions, and then records the electrical activity in acute brain slices to study the neural circuits and the properties of these connections. The group is mapping the circuits that provide auditory and noxious information to the amygdala, and is in interested in the circuits that connect the amygdala with the prefrontal cortex and hippocampus. This information is then used to understand the role of these circuits in behaviour.

IThe group is exploring the molecular identity of receptors at inhibitory connections in the amygdala. In the last year this work has concentrated on the properties of synaptic γ-aminobutyric (GABA) receptors that contain γ1 subunits. These receptors are enriched in specific circuits in the amygdala and could be targets for the development of new anxiolytic drugs.

The animal studies are complemented by electrophysiological recordings in humans. For these studies, Professor Sah collaborates with Professor Peter Silburn and Dr Terry Coyne who together are part of the Asia–Pacific Centre for Neuromodulation (APCN), to study neural activity in the human brain in patients undergoing neurosurgery for deep brain stimulation. These recordings are revealing the activity in the human brain in a range of movement disorders, such as Parkinson’s disease, essential tremor and Tourette syndrome. In 2016, the group begun a clinical trial for the treatment of obsessive compulsive disorder.

Group leader

Professor Pankaj Sah

Professor Pankaj Sah

Institute Director, Queensland Brain Institute

  @pankajqbi
  +61 7 334 66311
  pankaj.sah@uq.edu.au
  UQ Researcher Profile

 

A protocol to investigate cellular and circuit mechanisms generating sharp wave ripple oscillations in rodent basolateral amygdala using ex vivo slices

Perumal, Madhusoothanan B. and Sah, Pankaj (2022). A protocol to investigate cellular and circuit mechanisms generating sharp wave ripple oscillations in rodent basolateral amygdala using ex vivo slices. STAR Protocols, 3 (1) 101085, 101085. doi: 10.1016/j.xpro.2021.101085

Hippocampus-prefrontal coupling regulates recognition memory for novelty discrimination

Wang, Cong, Furlong, Teri M., Stratton, Peter G., Lee, Conrad C. Y., Xu, Li, Merlin, Sam, Nolan, Christoph, Arabzadeh, Ehsan, Marek, Roger and Sah, Pankaj (2021). Hippocampus-prefrontal coupling regulates recognition memory for novelty discrimination. The Journal of Neuroscience, 41 (46), 9617-9632. doi: 10.1523/jneurosci.1202-21.2021

Energy-level manipulation in novel indacenodithiophene-based donor–acceptor polymers for near-infrared organic photodetectors

Bhat, Gurudutt, Liu, Qian, Kielar, Marcin, Hamada, Yuya, Michinobu, Tsuyoshi, Sah, Pankaj, Ko Kyaw, Aung Ko, Pandey, Ajay K. and Sonar, Prashant (2021). Energy-level manipulation in novel indacenodithiophene-based donor–acceptor polymers for near-infrared organic photodetectors. ACS Applied Materials and Interfaces, 13 (25) acsami.1c03643, 29866-29875. doi: 10.1021/acsami.1c03643

Saturated free fatty acids and association with memory formation

Wallis, Tristan P., Venkatesh, Bharat G., Narayana, Vinod K., Kvaskoff, David, Ho, Alan, Sullivan, Robert K., Windels, François, Sah, Pankaj and Meunier, Frédéric A. (2021). Saturated free fatty acids and association with memory formation. Nature Communications, 12 (1) 3443, 3443. doi: 10.1038/s41467-021-23840-3

Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling

Blackmore, Daniel G., Turpin, Fabrice, Palliyaguru, Tishila, Evans, Harrison T., Chicoteau, Antony, Lee, Wendy, Pelekanos, Matthew, Nguyen, Nghia, Song, Jae, Sullivan, Robert K. P., Sah, Pankaj, Bartlett, Perry F. and Götz, Jürgen (2021). Low-intensity ultrasound restores long-term potentiation and memory in senescent mice through pleiotropic mechanisms including NMDAR signaling. Molecular Psychiatry, 26 (11), 6975-6991. doi: 10.1038/s41380-021-01129-7

Selective ablation of BDNF from microglia reveals novel roles in self-renewal and hippocampal neurogenesis

Harley, Samuel B. R., Willis, Emily F., Shaikh, Samreen N., Blackmore, Daniel G., Sah, Pankaj, Ruitenberg, Marc J., Bartlett, Perry F. and Vukovic, Jana (2021). Selective ablation of BDNF from microglia reveals novel roles in self-renewal and hippocampal neurogenesis. The Journal of Neuroscience, 41 (19), 4172-4186. doi: 10.1523/jneurosci.2539-20.2021

Microcircuit mechanisms for the generation of sharp-wave ripples in the basolateral amygdala: A role for chandelier interneurons

Perumal, Madhusoothanan B., Latimer, Benjamin, Xu, Li, Stratton, Peter, Nair, Satish and Sah, Pankaj (2021). Microcircuit mechanisms for the generation of sharp-wave ripples in the basolateral amygdala: A role for chandelier interneurons. Cell Reports, 35 (6) 109106, 1-16. doi: 10.1016/j.celrep.2021.109106

Inhibitory circuits in the basolateral amygdala in aversive learning and memory

Perumal, Madhusoothanan B. and Sah, Pankaj (2021). Inhibitory circuits in the basolateral amygdala in aversive learning and memory. Frontiers in Neural Circuits, 15, 633235. doi: 10.3389/fncir.2021.633235

A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder

Mosley, Philip E., Windels, François, Morris, John, Coyne, Terry, Marsh, Rodney, Giorni, Andrea, Mohan, Adith, Sachdev, Perminder, O’Leary, Emily, Boschen, Mark, Sah, Pankaj and Silburn, Peter A. (2021). A randomised, double-blind, sham-controlled trial of deep brain stimulation of the bed nucleus of the stria terminalis for treatment-resistant obsessive-compulsive disorder. Translational Psychiatry, 11 (1) 190, 190. doi: 10.1038/s41398-021-01307-9

Direct detection of neuronal activity using organic photodetectors

Kielar, Marcin, Gooch, Helen, Xu, Li, Pandey, Ajay K. and Sah, Pankaj (2020). Direct detection of neuronal activity using organic photodetectors. ACS Photonics, 8 (1) acsphotonics.0c01378, 228-237. doi: 10.1021/acsphotonics.0c01378

Somatostatin neurons in the central amygdala mediate anxiety by disinhibition of the central sublenticular extended amygdala

Sun, Yajie, Qian, Lei, Xu, Li, Hunt, Sarah and Sah, Pankaj (2020). Somatostatin neurons in the central amygdala mediate anxiety by disinhibition of the central sublenticular extended amygdala. Molecular Psychiatry. doi: 10.1038/s41380-020-00894-1

Editorial: Integrative Brain Function Down Under

Sah, Pankaj, Stuart, Greg J. and Egan, Gary F. (2020). Editorial: Integrative Brain Function Down Under. Frontiers in Neural Circuits, 14 48, 48. doi: 10.3389/fncir.2020.00048

Diversity of interneurons in the lateral and basal amygdala

Polepalli, Jai S., Gooch, Helen and Sah, Pankaj (2020). Diversity of interneurons in the lateral and basal amygdala. npj Science of Learning, 5 (1) 10, 10. doi: 10.1038/s41539-020-0071-z

Fear conditioning and the basolateral amygdala [version 1; peer review: 3 approved]

Sun, Yajie, Gooch, Helen and Sah, Pankaj (2020). Fear conditioning and the basolateral amygdala [version 1; peer review: 3 approved]. F1000Research, 9 53. doi: 10.12688/f1000research.21201.1

Light detection in open-circuit voltage mode of organic photodetectors

Kielar, Marcin, Hamid, Tasnuva, Wiemer, Martin, Windels, François, Hirsch, Lionel, Sah, Pankaj and Pandey, Ajay K. (2019). Light detection in open-circuit voltage mode of organic photodetectors. Advanced Functional Materials, 30 (9) 1907964, 1-9. doi: 10.1002/adfm.201907964

1,25-Dihydroxyvitamin D modulates L-type voltage-gated calcium channels in a subset of neurons in the developing mouse prefrontal cortex

Gooch, Helen, Cui, Xiaoying, Anggono, Victor, Trzaskowski, Maciej, Tan, Men Chee, Eyles, Darryl W., Burne, Thomas H. J., Jang, Se Eun, Mattheisen, Manuel, Hougaard, David M., Pedersen, Bent Nørgaard, Cohen, Arieh, Mortensen, Preben B., Sah, Pankaj and McGrath, John J. (2019). 1,25-Dihydroxyvitamin D modulates L-type voltage-gated calcium channels in a subset of neurons in the developing mouse prefrontal cortex. Translational Psychiatry, 9 (1) 281, 281. doi: 10.1038/s41398-019-0626-z

Interneurons in the prefrontal cortex: a role in the genesis of anxiety in adolescence?

Sah, Pankaj (2019). Interneurons in the prefrontal cortex: a role in the genesis of anxiety in adolescence?. Biological Psychiatry, 86 (9), 650-651. doi: 10.1016/j.biopsych.2019.07.026

Spectral changes associated with transmission of OLED emission through human skin

Yambem, Soniya D., Brooks-Richards, Trent L., Forrestal, David P., Kielar, Marcin, Sah, Pankaj, Pandey, Ajay K. and Woodruff, Maria A. (2019). Spectral changes associated with transmission of OLED emission through human skin. Scientific Reports, 9 (1) 9875, 9875. doi: 10.1038/s41598-019-45867-9

Organic optoelectronic diodes as tactile sensors for soft-touch applications

Kielar, Marcin, Hamid, Tasnuva, Wu, Liao, Windels, François, Sah, Pankaj and Pandey, Ajay K. (2019). Organic optoelectronic diodes as tactile sensors for soft-touch applications. ACS Applied Materials & Interfaces, 11 (24) acsami.9b04671, 21775-21783. doi: 10.1021/acsami.9b04671

rSK1 in rat neurons: a controller of membrane rSK2?

Autuori, Eleonora, Sedlak, Petra, Xu, Li, C. Ridder, Margreet, Tedoldi, Angelo and Sah, Pankaj (2019). rSK1 in rat neurons: a controller of membrane rSK2?. Frontiers in Neural Circuits, 13 21, 21. doi: 10.3389/fncir.2019.00021

Neural circuits for a top-down control of fear and extinction

Marek, Roger, Sun, Yajie and Sah, Pankaj (2019). Neural circuits for a top-down control of fear and extinction. Psychopharmacology, 236 (1), 313-320. doi: 10.1007/s00213-018-5033-2

Elongator mutation in mice induces neurodegeneration and ataxia-like behavior

Kojic, Marija, Gaik, Monika, Kiska, Bence, Salerno-Kochan, Anna, Hunt, Sarah, Tedoldi, Angelo, Mureev, Sergey, Jones, Alun, Whittle, Belinda, Genovesi, Laura A., Adolphe, Christelle, Brown, Darren L., Stow, Jennifer L., Alexandrov, Kirill, Sah, Pankaj, Glatt, Sebastian and Wainwright, Brandon J. (2018). Elongator mutation in mice induces neurodegeneration and ataxia-like behavior. Nature Communications, 9 (1) 3195, 3195. doi: 10.1038/s41467-018-05765-6

The association between neonatal vitamin D status and risk of schizophrenia

Eyles, Darryl W., Trzaskowski, Maciej, Vinkhuyzen, Anna A. E., Mattheisen, Manuel, Meier, Sandra, Gooch, Helen, Anggono, Victor, Cui, Xiaoying, Tan, Men Chee, Burne, Thomas H. J., Jang, Se Eun, Kvaskoff, David, Hougaard, David M., Nørgaard-Pedersen, Bent, Cohen, Arieh, Agerbo, Esben, Pedersen, Carsten B., Børglum, Anders D., Mors, Ole, Sah, Pankaj, Wray, Naomi R., Mortensen, Preben B. and McGrath, John J. (2018). The association between neonatal vitamin D status and risk of schizophrenia. Scientific Reports, 8 (1) 17692, 17692. doi: 10.1038/s41598-018-35418-z

Author Correction: Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear

Marek, Roger, Jin, Jingji, Goode, Travis D., Giustino, Thomas F., Wang, Qian, Acca, Gillian M., Holehonnur, Roopashri, Ploski, Jonathan E., Fitzgerald, Paul J., Lynagh, Timothy, Lynch, Joseph W., Maren, Stephen and Sah, Pankaj (2018). Author Correction: Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear. Nature Neuroscience, 21 (9), 1291-1291. doi: 10.1038/s41593-018-0183-4

Excitatory connections between the prelimbic and infralimbic medial prefrontal cortex show a role for the prelimbic cortex in fear extinction

Marek, Roger, Xu, Li, Sullivan, Robert K. P. and Sah, Pankaj (2018). Excitatory connections between the prelimbic and infralimbic medial prefrontal cortex show a role for the prelimbic cortex in fear extinction. Nature Neuroscience, 21 (5), 654-658. doi: 10.1038/s41593-018-0137-x

GABA A receptors and inhibitory neurotransmission in the amygdalar complex

Perumal, Madhusoothanan B., Lynch, Joseph W. and Sah, Pankaj (2018). GABA A receptors and inhibitory neurotransmission in the amygdalar complex. Current Opinion in Physiology, 2, 58-64. doi: 10.1016/j.cophys.2018.01.003

The nature and nurture of education

Sah, Pankaj, Fanselow, Michael, Quirk, Gregory J., Hattie, John, Mattingley, Jason and Tokuhama-Espinosa, Tracey (2018). The nature and nurture of education. npj Science of Learning, 3 (1) 6, 6. doi: 10.1038/s41539-018-0023-z

Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear

Marek, Roger, Jin, Jingji, Goode, Travis D., Giustino, Thomas F., Wang, Qian, Acca, Gillian M., Holehonnur, Roopashri, Ploski, Jonathan E., Fitzgerald, Paul J., Lynagh, Timothy, Lynch, Joseph W., Maren, Stephen and Sah, Pankaj (2018). Hippocampus-driven feed-forward inhibition of the prefrontal cortex mediates relapse of extinguished fear. Nature Neuroscience, 21 (3), 1-9. doi: 10.1038/s41593-018-0073-9

Multimodal analysis of aged wild-type mice exposed to repeated scanning ultrasound treatments demonstrates long-term safety

Blackmore, Daniel G., Turpin, Fabrice, Mohamed, Abdalla Z., Zong, Fangrong, Pandit, Rucha, Pelekanos, Matthew, Nasrallah, Fatima, Sah, Pankaj, Bartlett, Perry F. and Gotz, Juergen (2018). Multimodal analysis of aged wild-type mice exposed to repeated scanning ultrasound treatments demonstrates long-term safety. Theranostics, 8 (22), 6233-6247. doi: 10.7150/thno.27941

Single-unit activity of the anterior Globus pallidus internus in Tourette patients and posterior Globus pallidus internus in dystonic patients

Giorni, Andrea, Windels, François, Stratton, Peter G., Cook, Raymond, Silberstein, Paul, Coyne, Terrence, Silburn, Peter A. and Sah, Pankaj (2017). Single-unit activity of the anterior Globus pallidus internus in Tourette patients and posterior Globus pallidus internus in dystonic patients. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 128 (12), 2510-2518. doi: 10.1016/j.clinph.2017.10.003

Fear, anxiety, and the amygdala

Sah, P. (2017). Fear, anxiety, and the amygdala. Neuron, 96 (1), 1-2. doi: 10.1016/j.neuron.2017.09.013

Evidence for newly generated interneurons in the basolateral amygdala of adult mice

Jhaveri, D. J., Tedoldi, A., Hunt, S., Sullivan, R., Watts, N. R., Power, J. M., Bartlett, P. F. and Sah, P. (2017). Evidence for newly generated interneurons in the basolateral amygdala of adult mice. Molecular Psychiatry, 23 (3), 521-532. doi: 10.1038/mp.2017.134

G-protein-coupled inwardly rectifying potassium (GIRK) channel activation by the p75 neurotrophin receptor is required for amyloid beta toxicity

May, Linda M., Anggono, Victor, Gooch, Helen M., Jang, Se E., Matusica, Dusan, Kerbler, Georg M., Meunier, Frederic A., Sah, Pankaj and Coulson, Elizabeth J. (2017). G-protein-coupled inwardly rectifying potassium (GIRK) channel activation by the p75 neurotrophin receptor is required for amyloid beta toxicity. Frontiers in Neuroscience, 11 (455) 455. doi: 10.3389/fnins.2017.00455

Calcium signalling in medial intercalated cell dendrites and spines

Strobel, Cornelia, Sullivan, Robert K. P., Stratton, Peter and Sah, Pankaj (2017). Calcium signalling in medial intercalated cell dendrites and spines. The Journal of Physiology, 595 (16), 5653-5669. doi: 10.1113/JP274261

Gamma 1-containing GABA-A receptors cluster at synapses where they mediate slower synaptic currents than gamma 2-containing GABA-A receptors

Dixon, Christine L., Sah, Pankaj, Keramidas, Angelo, Lynch, Joseph W. and Durisic, Nela (2017). Gamma 1-containing GABA-A receptors cluster at synapses where they mediate slower synaptic currents than gamma 2-containing GABA-A receptors. Frontiers in Molecular Neuroscience, 10 178, 178. doi: 10.3389/fnmol.2017.00178

A chemogenetic receptor that enhances the magnitude and frequency of glycinergic inhibitory postsynaptic currents without inducing a tonic chloride flux

Islam, Robiul, Zhang, Yan, Xu, Li, Sah, Pankaj and Lynch, Joseph W. (2017). A chemogenetic receptor that enhances the magnitude and frequency of glycinergic inhibitory postsynaptic currents without inducing a tonic chloride flux. ACS Chemical Neuroscience, 8 (3), 460-467. doi: 10.1021/acschemneuro.6b00382

Intrinsic circuits in the lateral central amygdala

Hunt, Sarah, Sun, Yajie, Kucukdereli, Hakan, Klein, Ruediger and Sah, Pankaj (2017). Intrinsic circuits in the lateral central amygdala. Eneuro, 4 (1) e0367-16.2017, ENEURO.0367-16.2017. doi: 10.1523/ENEURO.0367-16.2017

Ivermectin-activated, cation-permeable glycine receptors for the chemogenetic control of neuronal excitation

Islam, Robiul, Keramidas, Angelo, Xu, Li, Durisic, Nela, Sah, Pankaj and Lynch, Joseph W. (2016). Ivermectin-activated, cation-permeable glycine receptors for the chemogenetic control of neuronal excitation. ACS Chemical Neuroscience, 7 (12), 1647-1657. doi: 10.1021/acschemneuro.6b00168

Neuroscience and education: mind the gap

Morris, John and Sah, Pankaj (2016). Neuroscience and education: mind the gap. Australian Journal of Education, 60 (2), 146-156. doi: 10.1177/0004944116652913

Auditory tones and foot-shock recapitulate spontaneous sub-threshold activity in basolateral amygdala principal neurons and interneurons

Windels, Francois, Yan, Shanzhi, Stratton, Peter G., Sullivan, Robert, Crane, James W. and Sah, Pankaj (2016). Auditory tones and foot-shock recapitulate spontaneous sub-threshold activity in basolateral amygdala principal neurons and interneurons. PLoS ONE, 11 (5) e0155192, e0155192. doi: 10.1371/journal.pone.0155192

Integrating neuroscience and learning: now’s the time

Sah, Pankaj, Fanselow, Michael, Hattie, John, Magsamen, Susan, Mattingley, Jason, Quirk, Gregory and Williams, Stephen (2016). Integrating neuroscience and learning: now’s the time. n p j Science of Learning, 1 (1) 16007, 16007. doi: 10.1038/npjscilearn.2016.7

IK1 channels do not contribute to the slow after hyperpolarization in pyramidal neurons

Wang, Kang, Mateos-Aparicio, Pedro, Honigsperger, Christoph, Raghuram, Vijeta, Wu, Wendy W., Ridder, Margreet C., Sah, Pankaj, Mayile, Jim, Storm, Johan F. and Adelman, John P. (2016). IK1 channels do not contribute to the slow after hyperpolarization in pyramidal neurons. eLife, 5 (e11206) e11206, 1-16. doi: 10.7554/eLife.11206

Development and physiology of GABAergic feedback excitation in parvalbumin expressing interneurons of the mouse basolateral amygdala

Spampanato, Jay, Sullivan, Robert K. P., Perumal, Madhusoothanan B. and Sah, Pankaj (2016). Development and physiology of GABAergic feedback excitation in parvalbumin expressing interneurons of the mouse basolateral amygdala. Physiological Reports, 4 (e12664) e12664, 1-15. doi: 10.14814/phy2.12664

Corrigendum: Regulating anxiety with extrasynaptic inhibition

Botta, Paolo, Demmou, Lynda, Kasugai, Yu, Markovic, Milica, Xu, Chun, Fadok, Jonathan P, Lu, Tingjia, Poe, Michael M, Xu, Li, Cook, James M, Rudolph, Uwe, Sah, Pankaj, Ferraguti, Francesco and Lüthi, Andreas (2015). Corrigendum: Regulating anxiety with extrasynaptic inhibition. Nature Neuroscience, 18 (12), 1862-1862. doi: 10.1038/nn1215-1862a

Regulating anxiety with extrasynaptic inhibition

Botta, Paolo, Demmou, Lynda, Kasugai, Yu, Markovic, Milica, Xu, Chun, Fadok, Jonathan P., Lu, Tingjia, Poe, Michael M., Xu, Li, Cook, James M., Rudolph, Uwe, Sah, Pankaj, Ferraguti, Francesco and Luthi, Andreas (2015). Regulating anxiety with extrasynaptic inhibition. Nature Neuroscience, 18 (10), 1493-1500. doi: 10.1038/nn.4102

Dendritic organization of olfactory inputs to medial amygdala neurons

Keshavarzi, Sepideh, Power, John M., Albers, Eva H.H., Sullivan, Robert K.S. and Sah, Pankaj (2015). Dendritic organization of olfactory inputs to medial amygdala neurons. Journal of Neuroscience, 35 (38), 13020-13028. doi: 10.1523/JNEUROSCI.0627-15.2015

Norepinephrine and Corticotropin-Releasing Hormone: Partners in the Neural Circuits that Underpin Stress and Anxiety

Sun, Yajie, Hunt, Sarah and Sah, Pankaj (2015). Norepinephrine and Corticotropin-Releasing Hormone: Partners in the Neural Circuits that Underpin Stress and Anxiety. Neuron, 87 (3), 468-470. doi: 10.1016/j.neuron.2015.07.022

Where and what is the PPN and what is its role in locomotion?

Windels, Francois, Thevathasan, Wesley, Silburn, Peter and Sah, Pankaj (2015). Where and what is the PPN and what is its role in locomotion?. Brain, 138 (5), 1133-1134. doi: 10.1093/brain/awv059

Vitamin D and the brain: key questions for future research

Cui, Xiaoying, Gooch, Helen, Groves, Natalie J., Sah, Pankaj, Burne, Thomas H., Eyles, Darryl W. and McGrath, John J. (2015). Vitamin D and the brain: key questions for future research. The Journal of Steroid Biochemistry and Molecular Biology, 148, 305-309. doi: 10.1016/j.jsbmb.2014.11.004

Prefrontal and auditory input to intercalated neurons of the Amygdala

Strobel, Cornelia, Marek, Roger, Gooch, Helen, Sullivan, Robert K. P. and Sah, Pankaj (2015). Prefrontal and auditory input to intercalated neurons of the Amygdala. Cell Reports, 10 (9), 1435-1442. doi: 10.1016/j.celrep.2015.02.008

Activity-Dependent ubiquitination of GluA1 and GluA2 regulates AMPA receptor intracellular sorting and degradation

Widagdo, Jocelyn, Chai, Ye Jin, Ridder, Margreet C, Chau, Yu Qian, Johnson, Richard C, Sah, Pankaj, Huganir, Richard L and Anggono, Victor (2015). Activity-Dependent ubiquitination of GluA1 and GluA2 regulates AMPA receptor intracellular sorting and degradation. Cell Reports, 10 (5), 783-795. doi: 10.1016/j.celrep.2015.01.015

Dendritic spine heterogeneity and calcium dynamics in basolateral amygdala principal neurons

Power, John M. and Sah, Pankaj P. (2014). Dendritic spine heterogeneity and calcium dynamics in basolateral amygdala principal neurons. Journal of Neurophysiology, 112 (7), 1616-1627. doi: 10.1152/jn.00770.2013

Balanced interhemispheric cortical activity is required for correct targeting of the corpus callosum

Suarez, Rodrigo, Fenlon, Laura R., Marek, Roger, Avitan, Lilach A, Sah, Pankaj, Goodhill, Geoffrey J. and Richards, Linda J. (2014). Balanced interhemispheric cortical activity is required for correct targeting of the corpus callosum. Neuron, 82 (6), 1289-1298. doi: 10.1016/j.neuron.2014.04.040

Emotional regulation of pain: the role of noradrenaline in the amygdala

Strobel, Cornelia, Hunt, Sarah, Sullivan, Robert, Sun, Jian and Sah, Pankaj (2014). Emotional regulation of pain: the role of noradrenaline in the amygdala. Science China Life Sciences, 57 (4), 384-390. doi: 10.1007/s11427-014-4638-x

GABAa receptor α and γ subunits shape synaptic currents via different mechanisms

Dixon, Christine, Sah, Pankaj, Lynch, Joseph W. and Keramidas, Angelo (2014). GABAa receptor α and γ subunits shape synaptic currents via different mechanisms. Journal of Biological Chemistry, 289 (9), 5399-5411. doi: 10.1074/jbc.M113.514695

Rodent scope: A user-configurable digital wireless telemetry system for freely behaving animals

Ball, David, Kliese, Russell, Windels, Francois, Nolan, Christopher, Stratton, Peter, Sah, Panjkaj and Wiles, Janet (2014). Rodent scope: A user-configurable digital wireless telemetry system for freely behaving animals. PLoS One, 9 (2) e89949, e89949.1-e89949.10. doi: 10.1371/journal.pone.0089949

Mechanisms of heterosynaptic metaplasticity

Hulme, Sarah R., Jones, Owen D., Raymond, Clarke R., Sah, Pankaj and Abraham, Wickliffe C. (2014). Mechanisms of heterosynaptic metaplasticity. Philosophical Transactions of the Royal Society B: Biological Sciences, 369 (1633) 20130148, 1633.1-1633.8. doi: 10.1098/rstb.2013.0148

Functional properties and projections of neurons in the medial amygdala

Keshavarzi, Sepideh, Sullivan, Robert K. P., Ianno, Damian J. and Sah, Pankaj (2014). Functional properties and projections of neurons in the medial amygdala. Journal of Neuroscience, 34 (26), 8699-8715. doi: 10.1523/JNEUROSCI.1176-14.2014

Imagined gait modulates neuronal network dynamics in the human pedunculopontine nucleus

Tattersall, Timothy L., Stratton, Peter G., Coyne, Terry J., Cook, Raymond, Silberstein, Paul, Silburn, Peter A., Windels, Francois and Sah, Pankaj (2014). Imagined gait modulates neuronal network dynamics in the human pedunculopontine nucleus. Nature Neuroscience, 17 (3), 449-454. doi: 10.1038/nn.3642

The amygdala and medial prefrontal cortex: partners in the fear circuit

Marek, Roger, Strobel, Cornelia, Bredy, Timothy W. and Sah, Pankaj (2013). The amygdala and medial prefrontal cortex: partners in the fear circuit. Journal of Physiology, 591 (10), 2381-2391. doi: 10.1113/jphysiol.2012.248575

Synaptic NMDA receptors in basolateral amygdala principal neurons are triheteromeric proteins: physiological role of GluN2B subunits

Delaney, Andrew J., Sedlak, Petra L., Autuori, Eleonora, Power, John M. and Sah, Pankaj (2013). Synaptic NMDA receptors in basolateral amygdala principal neurons are triheteromeric proteins: physiological role of GluN2B subunits. Journal of Neurophysiology, 109 (5), 1391-1402. doi: 10.1152/jn.00176.2012

Lesions of the basal forebrain cholinergic system in mice disrupt idiothetic navigation

Hamlin, Adam S., Windels, Francois, Boskovic, Zoran, Sah, Pankaj and Coulson, Elizabeth J. (2013). Lesions of the basal forebrain cholinergic system in mice disrupt idiothetic navigation. PLoS ONE, 8 (1) e53472, e53472.1-e53472.9. doi: 10.1371/journal.pone.0053472

Properties of doublecortin expressing neurons in the adult mouse dentate gyrus

Spampanato, Jay, Sullivan, Robert K., Turpin, Fabrice R., Bartlett, Perry F. and Sah, Pankaj (2012). Properties of doublecortin expressing neurons in the adult mouse dentate gyrus. PLoS One, 7 (9) e41029, e41029-1-e41029-12. doi: 10.1371/journal.pone.0041029

p300/CBP-associated factor selectively regulates the extinction of conditioned fear

Wei, Wei, Coelho, Carlos M., Li, Xiang, Marek, Roger, Yan, Shanzhi, Anderson, Shawn, Meyers, David, Mukherjee, Chandrani, Sbardella, Gianluca, Castellano, Sabrina, Milite, Ciro, Rotili, Dante, Mai, Antonello, Cole, Philip A., Sah, Pankaj, Kobor, Michael S. and Bredy, Timothy W. (2012). p300/CBP-associated factor selectively regulates the extinction of conditioned fear. Journal of Neuroscience, 32 (35), 11930-11941. doi: 10.1523/JNEUROSCI.0178-12.2012

Targeted ablation of oligodendrocytes induces axonal pathology independent of overt demyelination

Oluich, Laura-Jane, Stratton, Jo Anne S., Xing, Yao Lulu, Ng, Sze Woei, Cate, Holly S., Sah, Pankaj, Windels, Francois, Kilpatrick, Trevor J. and Merson, Tobias D. (2012). Targeted ablation of oligodendrocytes induces axonal pathology independent of overt demyelination. The Journal of Neuroscience, 32 (24), 8317-8330. doi: 10.1523/JNEUROSCI.1053-12.2012

Action potential waveform variability limits multi-unit separation in freely behaving rats

Stratton, Peter, Cheung, Allen, Wiles, Janet H., Kiyatkin, E., Sah, Pankaj and Windels, Francois (2012). Action potential waveform variability limits multi-unit separation in freely behaving rats. PLoS One, 7 (6) e38482, e38482.1-e38482.16. doi: 10.1371/journal.pone.0038482

An introduction to a symposium dedicated to the scientific achievements of Roger Nicoll

Jahr, Craig, Perkel, David and Sah, Pankaj (2012). An introduction to a symposium dedicated to the scientific achievements of Roger Nicoll. Journal of Physiology, 590 (10), 2201-2202. doi: 10.1113/jphysiol.2012.230896

Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels

Delaney, Andrew J., Power, John M. and Sah, Pankaj (2012). Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels. Journal of Neurophysiology, 107 (6), 1571-1575. doi: 10.1152/jn.01066.2011

Small-conductance Ca(2+)-activated K(+) channels: form and function

Adelman, John P., Maylie, James and Sah, Pankaj (2012). Small-conductance Ca(2+)-activated K(+) channels: form and function. Annual Review of Physiology, 74, 245-269. doi: 10.1146/annurev-physiol-020911-153336

Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300

Marek, Roger, Coelho, Carlos M., Sullivan, Robert K. P., Baker-Andresen, Danay, Li, Xiang, Ratnu, Vikram, Dudley, Kevin J., Meyers, David, Mukherjee, Chandrani, Cole, Philip A., Sah, Pankaj and Bredy, Timothy W. (2011). Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300. Journal of Neuroscience, 31 (20), 7486-7491. doi: 10.1523/JNEUROSCI.0133-11.2011

Interneurons in the basolateral amygdala

Spampanato, Jay, Polepalli, Jai and Sah, Pankaj (2011). Interneurons in the basolateral amygdala. Neuropharmacology, 60 (5), 765-773. doi: 10.1016/j.neuropharm.2010.11.006

Location and function of the slow afterhyperpolarization channels in the basolateral amygdala

Power, John M., Bocklisch, Christina, Curby, Peter and Sah, Pankaj (2011). Location and function of the slow afterhyperpolarization channels in the basolateral amygdala. Journal of Neuroscience, 31 (2), 526-537. doi: 10.1523/JNEUROSCI.1045-10.2011

Inhibition dominates the early phase of up-states in the basolateral amygdala

Windels, Francois, Crane, James W. and Sah, Pankaj (2010). Inhibition dominates the early phase of up-states in the basolateral amygdala. Journal of Neurophysiology, 104 (6), 3433-3438. doi: 10.1152/jn.00531.2010

A Specific class of interneuron mediates inhibitory plasticity in the lateral amygdala

Polepalli, Jai S., Sullivan, Robert K. P., Yanagawa, Yuchio and Sah, Pankaj (2010). A Specific class of interneuron mediates inhibitory plasticity in the lateral amygdala. Journal of Neuroscience, 30 (44), 14619-14629. doi: 10.1523/JNEUROSCI.3252-10.2010

Differential expression of glycine receptor subunits in the rat basolateral and central amygdala

Delaney, A. J., Esmaeili, A., Sedlak, Petra L., Lynch, J. W. and Sah, P. (2010). Differential expression of glycine receptor subunits in the rat basolateral and central amygdala. Neuroscience Letters, 469 (2), 237-242. doi: 10.1016/j.neulet.2009.12.003

Oscillations in the basolateral amygdala: aversive stimulation is state dependent and resets the oscillatory phase

Crane, James W., Windels, Francois and Sah, Pankaj (2009). Oscillations in the basolateral amygdala: aversive stimulation is state dependent and resets the oscillatory phase. Journal Neurophysiology, 102 (3), 1379-1387. doi: 10.1152/jn.00438.2009

GABAᴀ receptors containing gamma 1 subunits contribute to inhibitory transmission in the central amygdala

Esmaeili, Abolghasem, Lynch, Joseph W. and Sah, Pankaj (2009). GABAᴀ receptors containing gamma 1 subunits contribute to inhibitory transmission in the central amygdala. Journal of Neurophysiology, 101 (1), 341-349. doi: 10.1152/jn.90991.2008

The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres

Crane, James W., Baiquni, Gilang P., Sullivan, Robert K. P., Lee, John D, Sah, Pankaj, Taylor, Stephen M, Noakes, Peter G. and Woodruff, Trent (2009). The C5a anaphylatoxin receptor CD88 is expressed in presynaptic terminals of hippocampal mossy fibres. Journal of Neuroinflammation, 6 (34) 34, 34.1-34.10. doi: 10.1186/1742-2094-6-34

Modulation of SK Channel Trafficking by Beta Adrenoceptors Enhances Excitatory Synaptic Transmission and Plasticity in the Amygdala

Faber, Elizabeth S. L., Delaney, Andrew J., Power, John M., Sedlak, Petra, Crane, James W. and Sah, Pankaj (2008). Modulation of SK Channel Trafficking by Beta Adrenoceptors Enhances Excitatory Synaptic Transmission and Plasticity in the Amygdala. Journal of Neuroscience, 28 (43), 10803-10813. doi: 10.1523/JNEUROSCI.1796-08.2008

Behavioural neuroscience: The circuit of fear

Sah, Pankaj and Westbrook, R. Federick (2008). Behavioural neuroscience: The circuit of fear. Nature, 454 (7204), 589-590. doi: 10.1038/454589a

Fear Conditioning and Long-term Potentiation in the Amygdala What Really Is the Connection?

Sah, Pankaj, Westbrook, R. F. and Luthi, A. (2008). Fear Conditioning and Long-term Potentiation in the Amygdala What Really Is the Connection?. Annals of the New York Academy of Science, 1129, 88-95. doi: 10.1196/annals.1417.020

Latent stem and progenitor cells in the hippocampus are activated by neural excitation

Walker, Tara L., White, Amanda, Black, Debra M., Wallace, Robyn H., Sah, Pankaj and Bartlett, Perry F. (2008). Latent stem and progenitor cells in the hippocampus are activated by neural excitation. Journal of Neuroscience, 28 (20), 5240-5247. doi: 10.1523/JNEUROSCI.0344-08.2008

Competition between Calcium-Activated K⁺ Channels Determines Cholinergic Action on Firing Properties of Basolateral Amygdala Projection Neurons

Power, John M. and Sah, Pankaj (2008). Competition between Calcium-Activated K⁺ Channels Determines Cholinergic Action on Firing Properties of Basolateral Amygdala Projection Neurons. Journal of Neuroscience, 28 (12), 3209-3220. doi: 10.1523/JNEUROSCI.4310-07.2008

p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate

Coulson, E. J., May, L. M., Osborne, S. L., Reid, K., Underwood, C. K., Meunier, F. A., Bartlett, P. F. and Sah, P. (2008). p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate. Journal of Neuroscience, 28 (1), 315-324. doi: 10.1523/JNEUROSCI.2699-07.2008

Inhibition and synchronization of basal amygdala principal neuron spiking by parvalbumin-positive interneurons

Woodruff, Alan R. and Sah, Pankaj (2007). Inhibition and synchronization of basal amygdala principal neuron spiking by parvalbumin-positive interneurons. Journal of Neurophysiology, 98 (5), 2956-2961. doi: 10.1152/jn.00739.2007

Distribution of IP3-mediated calcium responses and their role in nuclear signalling in rat basolateral amygdala neurons

Power, John M. and Sah, Pankaj (2007). Distribution of IP3-mediated calcium responses and their role in nuclear signalling in rat basolateral amygdala neurons. Journal of Physiology, 580 (3), 835-857. doi: 10.1113/jphysiol.2006.125062

Bidirectional synaptic plasticity at nociceptive afferents in the rat central amygdala

Lopez de Armentia, M. and Sah, P. (2007). Bidirectional synaptic plasticity at nociceptive afferents in the rat central amygdala. Journal of Physiology, 581 (3), 961-970. doi: 10.1113/jphysiol.2007.101822

Functions of SK channels in central neurons

Faber, E. S. L. and Sah, P. (2007). Functions of SK channels in central neurons. Clinical and Experimental Pharmacology and Physiology, 34 (10), 1077-1083. doi: 10.1111/j.1440-1681.2007.04725.x

Networks of parvalbumin-positive interneurons in the basolateral amygdala

Woodruff, Alan R. and Sah, Pankaj (2007). Networks of parvalbumin-positive interneurons in the basolateral amygdala. Journal of Neuroscience, 27 (3), 553-563. doi: 10.1523/JNEUROSCI.3686-06.2007

Noradrenaline modulates transmission at a central synapse by a presynaptic mechanism

Delaney, Andrew J., Crane, James W. and Sah, Pankaj (2007). Noradrenaline modulates transmission at a central synapse by a presynaptic mechanism. Neuron, 56 (5), 880-892. doi: 10.1016/j.neuron.2007.10.022

Sez-6 proteins affect dendritic arborization patterns and excitability of cortical pyramidal neurons

Gunnersen, J. M., Kim, M. H., Fuller, S. J., De Silva, M., Britto, J. M., Hammond, V. E., Davies, P. J., Petrou, S., Faber, E. S. L., Sah, P. and Tan, S. S. (2007). Sez-6 proteins affect dendritic arborization patterns and excitability of cortical pyramidal neurons. Neuron, 56 (4), 621-639. doi: 10.1016/j.neuron.2007.09.018

Canonical organization of opioid modulation of nociceptive circuits. Focus on "mu opioid receptor activation inhibits GABAergic inputs to basolateral amygdala neurons through Kv1.1/Kv1.2 channels"

Sah, Pankaj (2006). Canonical organization of opioid modulation of nociceptive circuits. Focus on "mu opioid receptor activation inhibits GABAergic inputs to basolateral amygdala neurons through Kv1.1/Kv1.2 channels". Journal of Neurophysiology, 95 (4), 2029-2030. doi: 10.1152/jn.01259.2005

Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants spastic, spasmodic, and oscillator

Graham, B. A., Schofield, P. R., Sah, P., Margrie, T. W. and Callister, R. J. (2006). Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants spastic, spasmodic, and oscillator. Journal of Neuroscience, 26 (18), 4880-4890. doi: 10.1523/JNEUROSCI.3991-05.2006

GABAergic excitation in the basolateral amygdala

Woodruff, Alan R., Monyer, Hannah and Sah, Pankaj (2006). GABAergic excitation in the basolateral amygdala. Journal of Neuroscience, 26 (46), 11881-11887. doi: 10.1523/JNEUROSCI.3389-06.2006

Synaptic activation of transient receptor potential channels by metabotropic glutamate receptors in the lateral amygdala

Faber, E. S. L., Sedlak, P., Vidovic, M. and Sah, P. (2006). Synaptic activation of transient receptor potential channels by metabotropic glutamate receptors in the lateral amygdala. Neuroscience, 137 (3), 781-794. doi: 10.1016/j.neuroscience.2005.09.027

Independent roles of calcium and voltage-dependent potassium currents in controlling spike frequency adaptation in lateral amygdala pyramidal neurons

Faber, E. S. L. and Sah, P. (2005). Independent roles of calcium and voltage-dependent potassium currents in controlling spike frequency adaptation in lateral amygdala pyramidal neurons. European Journal of Neuroscience, 22 (7), 1627-1635. doi: 10.1111/j.1460-9568.2005.04357.x

Intracellular calcium store filling by an L-type calcium current in the basolateral amygdala at subthreshold membrane potentials

Power, J. M. and Sah, P. (2005). Intracellular calcium store filling by an L-type calcium current in the basolateral amygdala at subthreshold membrane potentials. Journal of Physiology, 562 (2), 439-453. doi: 10.1113/jphysiol.2004.076711

SK channels regulate excitatory synaptic transmission and plasticity in the lateral amygdala

Faber, E. S., Delaney, A. J. and Sah, P. (2005). SK channels regulate excitatory synaptic transmission and plasticity in the lateral amygdala. Nature Neuroscience, 8 (5), 635-641. doi: 10.1038/nn1450

Firing properties and connectivity of neurons in the rat lateral central nucleus of the amygdala

De Armentia, Mikel Lopez and Sah, Pankaj (2004). Firing properties and connectivity of neurons in the rat lateral central nucleus of the amygdala. Journal of Neurophysiology, 92 (3), 1285-1294. doi: 10.1152/jn.00211.2004

Opioids Inhibit Lateral Amygdala Pyramidal Neurons by Enhancing A Dendritic Potassium Current

Faber, E. S. L. and Sah, P. (2004). Opioids Inhibit Lateral Amygdala Pyramidal Neurons by Enhancing A Dendritic Potassium Current. Journal of Neuroscience, 24 (12), 3031-3039. doi: 10.1523/JNEUROSCI.4496-03.2004

Altered inhibitory synaptic transmission in superficial dorsal horn neurones in spastic and oscillator mice

Graham, BA, Schofield, PR, Sah, P and Callister, RJ (2003). Altered inhibitory synaptic transmission in superficial dorsal horn neurones in spastic and oscillator mice. Journal of Physiology-london, 551 (3), 905-916. doi: 10.1113/jphysiol.2003.049064

Ca2+-activated K+(BK) channel inactivation contributes to spike broadening during repetitive firing in the rat lateral amygdala

Faber, E. S. L. and Sah, P. (2003). Ca2+-activated K+(BK) channel inactivation contributes to spike broadening during repetitive firing in the rat lateral amygdala. Journal of Physiology, 552 (2), 483-497. doi: 10.1113/jphysiol.2003.050120

Calcium-activated potassium channels: Multiple contributions to neuronal function

Faber, ESL and Sah, P (2003). Calcium-activated potassium channels: Multiple contributions to neuronal function. Neuroscientist, 9 (3), 181-194. doi: 10.1177/107385840325673

Development and subunit composition of synaptic NMDA receptors in the amygdala: NR2B Synapses in the adult central amygdala

De Armentia, Mikel Lopez and Sah, Pankaj (2003). Development and subunit composition of synaptic NMDA receptors in the amygdala: NR2B Synapses in the adult central amygdala. Journal of Neuroscience, 23 (17), 6876-6883. doi: 10.1523/jneurosci.23-17-06876.2003

Excitatory synaptic transmission in the lateral and central amygdala

Sah, P. and De Armentia, M. L. (2003). Excitatory synaptic transmission in the lateral and central amygdala. Annals of New York Academy of Sciences, 985 (THE AMYGDALA IN BRAIN FUNCTION Basic and Clinical Approaches), 67-77. doi: 10.1111/j.1749-6632.2003.tb07072.x

The amygdaloid complex: Anatomy and physiology

Sah, P, Faber, ESL, De Armentia, ML and Power, J (2003). The amygdaloid complex: Anatomy and physiology. Physiological Reviews, 83 (3), 803-834. doi: 10.1152/physrev.00002.2003

Channels underlying neuronal calcium-activated potassium currents

Sah, Pankaj and Faber, E S Louise (2002). Channels underlying neuronal calcium-activated potassium currents. Progress in Neurobiology, 66 (5), 345-53. doi: 10.1016/S0301-0082(02)00004-7

Channels underlying neuronal calcium-activated potassium currents

Sah, P and Faber, ESL (2002). Channels underlying neuronal calcium-activated potassium currents. Progress In Neurobiology, 66 (5), 345-353. doi: 10.1016/S0301-0082(02)00004-7

Neurobiology - Never fear, cannabinoids are here

Sah, P (2002). Neurobiology - Never fear, cannabinoids are here. Nature, 418 (6897), 488-489. doi: 10.1038/418488b

Nuclear calcium signaling evoked by cholinergic stimulation in hippocampal CA1 pyramidal neurons

Power, JM and Sah, P (2002). Nuclear calcium signaling evoked by cholinergic stimulation in hippocampal CA1 pyramidal neurons. Journal of Neuroscience, 22 (9), 3454-3462.

Physiological role of calcium-activated potassium currents in the rat lateral amygdala

Faber, ESL and Sah, P (2002). Physiological role of calcium-activated potassium currents in the rat lateral amygdala. Journal of Neuroscience, 22 (5), 1618-1628. doi: 10.1523/jneurosci.22-05-01618.2002

Morphological and electrophysiological properties of principal neurons in the rat lateral amygdala in vitro

Faber, ESL, Callister, RJ and Sah, P (2001). Morphological and electrophysiological properties of principal neurons in the rat lateral amygdala in vitro. Journal of Neurophysiology, 85 (2), 714-723. doi: 10.1152/jn.2001.85.2.714

Pathway-specific targeting of GAB(A) a receptor subtypes to somatic and dendritic synapses in the central amygdala

Delaney, A. J. and Sah, P. (2001). Pathway-specific targeting of GAB(A) a receptor subtypes to somatic and dendritic synapses in the central amygdala. Journal of Neurophysiology, 86 (2), 717-723.

Calcium-activated potassium currents in mammalian neurons

Sah, P and Davies, P (2000). Calcium-activated potassium currents in mammalian neurons. Clinical And Experimental Pharmacology And Physiology, 27 (9), 657-663. doi: 10.1046/j.1440-1681.2000.03317.x

Inhibition of transmitter release and long-term depression in the avian hippocampus

Margrie, TW, Rostas, JAP and Sah, P (2000). Inhibition of transmitter release and long-term depression in the avian hippocampus. Neuroscience Letters, 284 (1-2), 17-20. doi: 10.1016/S0304-3940(00)00992-7

Excitatory synaptic inputs to pyramidal neurons of the lateral amygdala

Mahanty, NK and Sah, P (1999). Excitatory synaptic inputs to pyramidal neurons of the lateral amygdala. European Journal of Neuroscience, 11 (4), 1217-1222. doi: 10.1046/j.1460-9568.1999.00528.x

GABA receptors inhibited by benzodiazepines mediate fast inhibitory transmission in the central amygdala

Delaney, AJ and Sah, P (1999). GABA receptors inhibited by benzodiazepines mediate fast inhibitory transmission in the central amygdala. Journal of Neuroscience, 19 (22), 9698-9704.

Molecular studies of synaptic neurotran fission: Development of transgenic animal models

Morgan, B, Callister, R, Handford, C, Walker, S, Sah, P and Schofield, P (1999). Molecular studies of synaptic neurotran fission: Development of transgenic animal models. Journal of Neurochemistry, 73, S88-S88.

Photolytic manipulation of [Ca2+](i) reveals slow kinetics of potassium channels underlying the afterhyperpolarization in hipppocampal pyramidal neurons

Sah, P and Clements, JD (1999). Photolytic manipulation of [Ca2+](i) reveals slow kinetics of potassium channels underlying the afterhyperpolarization in hipppocampal pyramidal neurons. Journal of Neuroscience, 19 (10), 3657-3664.

Use of murine mutants to study glycine receptor function

Callister, RJ, Schofield, PR and Sah, P (1999). Use of murine mutants to study glycine receptor function. Clinical And Experimental Pharmacology And Physiology, 26 (11), 929-931. doi: 10.1046/j.1440-1681.1999.03148.x

Are there functional P2X receptors on cell bodies in intact dorsal root ganglia of rats?

Stebbing, MJ, McLachlan, EM and Sah, P (1998). Are there functional P2X receptors on cell bodies in intact dorsal root ganglia of rats?. Neuroscience, 86 (4), 1235-1244. doi: 10.1016/S0306-4522(98)00127-4

Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala

Mahanty, Nishith K. and Sah, Pankaj (1998). Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala. Nature, 394 (6694), 683-687. doi: 10.1038/29312

Long-term potentiation of synaptic transmission in the avian hippocampus

Margrie, TW, Rostas, JAP and Sah, P (1998). Long-term potentiation of synaptic transmission in the avian hippocampus. Journal of Neuroscience, 18 (4), 1207-1216.

Neuroplasticity and psychiatry

Gynther, BD, Calford, MB and Sah, P (1998). Neuroplasticity and psychiatry. Australian And New Zealand Journal of Psychiatry, 32 (1), 119-128. doi: 10.3109/00048679809062718

Presynaptic long-term depression at a central glutamatergic synapse: a role for CaMKII

Margrie, TW, Rostas, JAP and Sah, P (1998). Presynaptic long-term depression at a central glutamatergic synapse: a role for CaMKII. Nature Neuroscience, 1 (5), 378-383.

Ca2+-activated K+ channels in rat otic ganglion cells: Role of Ca2+ entry via Ca2+ channels and nicotinic receptors

Callister, RJ, Keast, JR and Sah, P (1997). Ca2+-activated K+ channels in rat otic ganglion cells: Role of Ca2+ entry via Ca2+ channels and nicotinic receptors. Journal of Physiology-london, 500 (3), 571-582. doi: 10.1113/jphysiol.1997.sp022043

NMDA receptor independent long-term potentiation in the avian hippocampus

Margrie, TW, Rostas, JAP and Sah, P (1997). NMDA receptor independent long-term potentiation in the avian hippocampus. Journal of Neurochemistry, 69, S66-S66.

The removal of acetylcholine by diffusion at nicotinic synapses in the rat otic ganglion

Callister, Robert J. and Sah, Pankaj (1997). The removal of acetylcholine by diffusion at nicotinic synapses in the rat otic ganglion. Journal of Physiology, 505 (1), 165-175. doi: 10.1111/j.1469-7793.1997.165bc.x

Apical dendritic location of slow afterhyperpolarization current in hippocampal pyramidal neurons: Implications for the integration of long-term potentiation

Sah, P and Bekkers, JM (1996). Apical dendritic location of slow afterhyperpolarization current in hippocampal pyramidal neurons: Implications for the integration of long-term potentiation. Journal of Neuroscience, 16 (15), 4537-4542.

Ca2+-activated K+ currents in neurones: Types, physiological roles and modulation

Sah, P (1996). Ca2+-activated K+ currents in neurones: Types, physiological roles and modulation. Trends in Neurosciences, 19 (4), 150-154. doi: 10.1016/S0166-2236(96)80026-9

Properties of Channels Mediating the Apamin-Insensitive Afterhyperpolarization in Vagal Motoneurons

Sah, P (1995). Properties of Channels Mediating the Apamin-Insensitive Afterhyperpolarization in Vagal Motoneurons. Journal of Neurophysiology, 74 (4), 1772-1776.

Channels Underlying the Slow Afterhyperpolarization in Hippocampal Pyramidal Neurons - Neurotransmitters Modulate the Open Probability

Sah, P and Isaacson, JS (1995). Channels Underlying the Slow Afterhyperpolarization in Hippocampal Pyramidal Neurons - Neurotransmitters Modulate the Open Probability. Neuron, 15 (2), 435-441. doi: 10.1016/0896-6273(95)90047-0

Membrane-Properties and Synaptic Potentials in Rat Sympathetic Preganglionic Neurons Studied in Horizontal Spinal-Cord Slices In-Vitro

Sah, P and McLachlan, EM (1995). Membrane-Properties and Synaptic Potentials in Rat Sympathetic Preganglionic Neurons Studied in Horizontal Spinal-Cord Slices In-Vitro. Journal of the Autonomic Nervous System, 53 (1), 1-15. doi: 10.1016/0165-1838(94)00161-C

Different Calcium Channels Are Coupled to Potassium Channels with Distinct Physiological Roles in Vagal Neurons

Sah, P (1995). Different Calcium Channels Are Coupled to Potassium Channels with Distinct Physiological Roles in Vagal Neurons. Proceedings of the Royal Society B-Biological Sciences, 260 (1357), 105-111. doi: 10.1098/rspb.1995.0066

Subcellular-Distribution of Ryanodine Receptor-Like and Calcium Atpase-Like Immunoreactivity in Brain-Stem and Cerebellar Neurons of Rat and Guinea-Pig

Sah, P, Dulhunty, A, Junankar, P and Stanhope, C (1994). Subcellular-Distribution of Ryanodine Receptor-Like and Calcium Atpase-Like Immunoreactivity in Brain-Stem and Cerebellar Neurons of Rat and Guinea-Pig. Neuroscience Letters, 166 (2), 143-148. doi: 10.1016/0304-3940(94)90471-5

Distribution of Ryanodine Receptor-Like Immunoreactivity in Mammalian Central-Nervous-System Is Consistent with its Role in Calcium-Induced Calcium Release

Sah, P, Francis, K, McLachlan, EM and Junankar, P (1993). Distribution of Ryanodine Receptor-Like Immunoreactivity in Mammalian Central-Nervous-System Is Consistent with its Role in Calcium-Induced Calcium Release. Neuroscience, 54 (1), 157-165. doi: 10.1016/0306-4522(93)90391-R

Calcium Induced Calcium Release Is Involved in the Afterhyperpolarization in One Class of Guinea-Pig Sympathetic Neuron

Jobling, P, McLachlan, EM and Sah, P (1993). Calcium Induced Calcium Release Is Involved in the Afterhyperpolarization in One Class of Guinea-Pig Sympathetic Neuron. Journal of the Autonomic Nervous System, 42 (3), 251-257. doi: 10.1016/0165-1838(93)90370-A

Differences in Electrophysiological Properties Between Neurons of the Dorsal Motor Nucleus of the Vagus in Rat and Guinea-Pig

Sah, P and McLachlan, EM (1993). Differences in Electrophysiological Properties Between Neurons of the Dorsal Motor Nucleus of the Vagus in Rat and Guinea-Pig. Journal of the Autonomic Nervous System, 42 (2), 89-98. doi: 10.1016/0165-1838(93)90041-R

Role of Calcium Influx and Buffering in the Kinetics of a Ca-2+-Activated K+ Current in Rat Vagal Motoneurons

Sah, P (1992). Role of Calcium Influx and Buffering in the Kinetics of a Ca-2+-Activated K+ Current in Rat Vagal Motoneurons. Journal of Neurophysiology, 68 (6), 2237-2247.

Potassium Currents Contributing to Action-Potential Repolarization and the Afterhyperpolarization in Rat Vagal Motoneurons

Sah, Paj and McLachlan, EM (1992). Potassium Currents Contributing to Action-Potential Repolarization and the Afterhyperpolarization in Rat Vagal Motoneurons. Journal of Neurophysiology, 68 (5), 1834-1841.

A Slow Voltage-Activated Potassium Current in Rat Vagal Neurons

Sah, P and McLachlan, EM (1992). A Slow Voltage-Activated Potassium Current in Rat Vagal Neurons. Proceedings of the Royal Society B-Biological Sciences, 249 (1324), 71-76. doi: 10.1098/rspb.1992.0085

Ca2+-Activated K+-Currents Underlying the Afterhyperpolarization in Guinea-Pig Vagal Neurons - a Role for Ca2+-Activated Ca2+ Release

Sah, P and McLachlan, EM (1991). Ca2+-Activated K+-Currents Underlying the Afterhyperpolarization in Guinea-Pig Vagal Neurons - a Role for Ca2+-Activated Ca2+ Release. Neuron, 7 (2), 257-264. doi: 10.1016/0896-6273(91)90264-Z

Mechanisms Underlying Potentiation of Synaptic Transmission in Rat Anterior Cingulate Cortex Invitro

Sah, P and Nicoll, RA (1991). Mechanisms Underlying Potentiation of Synaptic Transmission in Rat Anterior Cingulate Cortex Invitro. Journal of Physiology-London, 433 (1), 615-630. doi: 10.1113/jphysiol.1991.sp018446

Properties of Excitatory Postsynaptic Currents Recorded Invitro From Rat Hippocampal Interneurons

Sah, P, Hestrin, S and Nicoll, RA (1990). Properties of Excitatory Postsynaptic Currents Recorded Invitro From Rat Hippocampal Interneurons. Journal of Physiology-London, 430, 605-616. doi: 10.1113/jphysiol.1990.sp018310

Properties of excitatory postsynaptic currents recorded in vitro from rat hippocampal interneurones

Sah, P, Hestrin, S and Nicoll, R A (1990). Properties of excitatory postsynaptic currents recorded in vitro from rat hippocampal interneurones. The Journal of Physiology, 430, 605-16. doi: 10.1113/jphysiol.1990.sp018310

Mechanisms Generating the Time Course of Dual Component Excitatory Synaptic Currents Recorded in Hippocampal Slices

Hestrin, S, Sah, P and Nicoll, RA (1990). Mechanisms Generating the Time Course of Dual Component Excitatory Synaptic Currents Recorded in Hippocampal Slices. Neuron, 5 (3), 247-253. doi: 10.1016/0896-6273(90)90162-9

Excitatory Synaptic Currents in Purkinje-Cells

Perkel, DJ, Hestrin, S, Sah, P and Nicoll, RA (1990). Excitatory Synaptic Currents in Purkinje-Cells. Proceedings of the Royal Society B-Biological Sciences, 241 (1301), 116-121. doi: 10.1098/rspb.1990.0074

A Voltage-Dependent Persistent Sodium Current in Mammalian Hippocampal-Neurons

French, CR, Sah, P, Buckett, KJ and Gage, PW (1990). A Voltage-Dependent Persistent Sodium Current in Mammalian Hippocampal-Neurons. Journal of General Physiology, 95 (6), 1139-1157. doi: 10.1085/jgp.95.6.1139

Analysis of Excitatory Synaptic Action in Pyramidal Cells Using Whole-Cell Recording From Rat Hippocampal Slices

Hestrin, S, Nicoll, RA, Perkel, DJ and Sah, P (1990). Analysis of Excitatory Synaptic Action in Pyramidal Cells Using Whole-Cell Recording From Rat Hippocampal Slices. Journal of Physiology-London, 422, 203-225.

Physiological-Properties of Excitatory Synaptic Transmission in the Central-Nervous-System

Hestrin, S, Perkel, DJ, Sah, P, Manabe, T, Renner, P and Nicoll, RA (1990). Physiological-Properties of Excitatory Synaptic Transmission in the Central-Nervous-System. Cold Spring Harbor Symposia On Quantitative Biology, 55, 87-93.

Tonic Activation of Nmda Receptors by Ambient Glutamate Enhances Excitability of Neurons

Sah, P, Hestrin, S and Nicoll, RA (1989). Tonic Activation of Nmda Receptors by Ambient Glutamate Enhances Excitability of Neurons. Science, 246 (4931), 815-818. doi: 10.1126/science.2573153

Potassium Current Activated by Depolarization of Dissociated Neurons From Adult Guinea-Pig Hippocampus

Sah, P, Gibb, AJ and Gage, PW (1988). Potassium Current Activated by Depolarization of Dissociated Neurons From Adult Guinea-Pig Hippocampus. Journal of General Physiology, 92 (2), 263-278. doi: 10.1085/jgp.92.2.263

The Sodium Current Underlying Action-Potentials in Guinea-Pig Hippocampal Ca1 Neurons

Sah, P, Gibb, AJ and Gage, PW (1988). The Sodium Current Underlying Action-Potentials in Guinea-Pig Hippocampal Ca1 Neurons. Journal of General Physiology, 91 (3), 373-398. doi: 10.1085/jgp.91.3.373

Effects of Noradrenaline On Some Potassium Currents in Ca1 Neurons in Rat Hippocampal Slices

Sah, P, French, CR and Gage, PW (1985). Effects of Noradrenaline On Some Potassium Currents in Ca1 Neurons in Rat Hippocampal Slices. Neuroscience Letters, 60 (3), 295-300. doi: 10.1016/0304-3940(85)90593-2

Postsynaptic Effects of Some Central Stimulants At the Neuromuscular-Junction

Gage, PW and Sah, P (1982). Postsynaptic Effects of Some Central Stimulants At the Neuromuscular-Junction. British Journal of Pharmacology, 75 (3), 493-502. doi: 10.1111/j.1476-5381.1982.tb09166.x

Conference Publication

Anatomy and physiology of the central extended amygdala

Sun, Y., Turpin, F., Xu, L. and Sah, P. (2015). Anatomy and physiology of the central extended amygdala25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex United Kingdom: Wiley-Blackwell. doi: 10.1111/jnc.13189

Cortical gating of sensory responses in the amygdala

Windels, F., Yan, S., Stratton, P., Crane, J. and Sah, P. (2015). Cortical gating of sensory responses in the amygdala25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, QLD Australia, 23-27 august 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188

Intrinsic circuitry of the lateral central amygdala

Hunt, S. and Sah, P. (2015). Intrinsic circuitry of the lateral central amygdala25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13188

Reverberating cell assemblies in the amygdala

Perumal, M. B., Sullivan, R. and Sah, P. (2015). Reverberating cell assemblies in the amygdala25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, Australia, Aug 23-27, 2015. Chichester, United Kingdom: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13189

Auditory stimulation modulates amygdala network dynamics

Windels, François, Stratton, Peter and Sah, Pankaj (2014). Auditory stimulation modulates amygdala network dynamicsThe Twenty Third Annual Computational Neuroscience Meeting: CNS*2014, Québec City, Canada, 26-31 July, 2014. London, United Kingdom: BioMed Central. doi: 10.1186/1471-2202-15-s1-p52

Excitatory and inhibitory circuits in the basolateral amygdala

Sah, Pankaj (2012). Excitatory and inhibitory circuits in the basolateral amygdala19th Biennial Meeting of the International Society for Developmental Neuroscience (ISDN), Mumbai India, 11-14 January 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/j.ijdevneu.2012.10.085

Kidney chloride regulation in the mouse CNS

Sullivan, R. K. P., Spampanato, J. and Sah, P. (2011). Kidney chloride regulation in the mouse CNSAustralian Neuroscience Society (ANS) 31st Annual Conference, Aukland New Zealand, 30 January - 3 February 2011.

NMDA receptors in the amygdala: a heterogeneity of form and function

Sah, P (2010). NMDA receptors in the amygdala: a heterogeneity of form and functionUnknown, Unknown, Unknown. TOKYO: SPRINGER TOKYO.

Recent advances in the role of the amygdala in memory storage, fear and anxiety

Sah, P (2010). Recent advances in the role of the amygdala in memory storage, fear and anxietyx, x, x. TOKYO: SPRINGER TOKYO.

Dendritic Branching and Excitatory Connectivity: Regulation by Seizure-Related Gene 6

Gunnersen, JM, Kim, MH, Fuller, SJ, De, SM, Barwood, JM, Hammond, VE, Britto, JM, Mateos, JM, Sonderegger, P, Faber, ES, Sah, P and Tan, SS (2009). Dendritic Branching and Excitatory Connectivity: Regulation by Seizure-Related Gene 622nd Biennial Meeting of the International-Society-of-Neurochemistry/Asian-Pacific-Society-for-Neurochemistry, Busan South Korea, Aug 23-29, 2009. MALDEN: WILEY-BLACKWELL PUBLISHING, INC.

Fear conditioning and long-term potentiation in the amygdala: What really is the connection?

Sah, P., Westbrook, R. F. and Lüthi, A. (2008). Fear conditioning and long-term potentiation in the amygdala: What really is the connection?. Blackwell Publishing Inc.. doi: 10.1196/annals.1417.020

Interneurons in the basolateral amygdala: A diversity of form and function

Woodruff, A., Polepalli, J., Yanagawa, Y. and Sah, P. (2008). Interneurons in the basolateral amygdala: A diversity of form and functionEighth Biennial Meeting of the Asia-Pacific Society for Neurochemistry, Shanghai, Peoples Republic of China, 23-26 June 2008. Oxford, England, U. K.: Wiley-Blackwell Publishing Ltd.. doi: 10.1111/j.1471-4159.2008.05367.x

Distribution and function of GABA(A) receptor subunits in the amygdala

Esmaeili, Abolghasem, Lynch, Joe and Sah, Pankaj (2006). Distribution and function of GABA(A) receptor subunits in the amygdalaThe 29th Annual Meeting of the Japan Neuroscience Society - (Neuroscience2006), Kyoto, Japan, 19-21 July 2006. Ireland, U.K.: Elsevier Ireland. doi: 10.1016/j.neures.2006.04.004

A chemically and electrically connected network of interneurons regulates principal neuron activity in the basolateral amygdala

Woodruff, A.R. and Sah, P. (2004). A chemically and electrically connected network of interneurons regulates principal neuron activity in the basolateral amygdalaAustralian Neuroscience Society 24th Annual Meeting, Melbourne Convention Centre, 27-30 January. Melbourne: Australian Neuroscience Society.

Calcium and voltage dependent potassium currents contribute to spike frequency adaptations in lateral amygdala neurons

Faber, E.S.L. and Sah, P. (2004). Calcium and voltage dependent potassium currents contribute to spike frequency adaptations in lateral amygdala neuronsAustralian Neuroscience Society 24th Annual Meeting, Melbourne Convention Centre, 27-30 January. Melbourne: Australian Neuroscience Society.

Stimulation of Girk channel activity by P75 neurotrophin receptor (p 75NTR) promotes neuronal death

Coulson, E., Sah, P., May, L. M., Morley, S. N. and Bartlett, P. F. (2004). Stimulation of Girk channel activity by P75 neurotrophin receptor (p 75NTR) promotes neuronal deathSociety for Neuroscience 34th Annual Meeting, San Diego, 23-27 October, 2004. Washington DC: Society for Neuroscience.

 

Research Areas

  • Electrophysiology and molecular techniques
  • Neural circuitry underpinning learning and memory formation
  • The amygdala and fear conditioning 
  • Deep brain stimulation (DBS)

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