Speaker

Dr Adam K. Walker, Department of Biomedical Sciences, Faculty of Medicine and Health, Macquarie University, NSW

Abstract

Motor neuron disease and frontotemporal dementia are devastating neurodegenerative diseases with seemingly disparate symptoms. However, most cases of both diseases are characterized by neuronal pathology containing the DNA/RNA-binding protein TDP-43. In this talk I will present findings from new transgenic TDP-43 mouse models, which recapitulate disease-reminiscent pathology, neurodegeneration and behavioural phenotypes. Importantly, I will show that halting TDP-43 accumulation allows neuron survival and functional recovery even at advanced stages of disease, suggesting that similar strategies could be beneficial in patients. I will also describe recent high-coverage quantitative proteomics studies, which have revealed potential new therapeutic targets for the treatment of TDP-43-associated diseases.

About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

While seminars in the QBI Auditorium have been suspended due to COVID-19, we will still be holding seminars via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details. 

 

Neuroscience Seminars archive 2005-2018

Venue

QBI Building (#79), St Lucia Campus
Room: 
Level 7 Auditorium