Investigating the disease mechanisms of MND and frontotemporal dementia related to TDP-43 pathology
Speaker
Dr Adam K. Walker, Department of Biomedical Sciences, Faculty of Medicine and Health, Macquarie University, NSW
Abstract
Motor neuron disease and frontotemporal dementia are devastating neurodegenerative diseases with seemingly disparate symptoms. However, most cases of both diseases are characterized by neuronal pathology containing the DNA/RNA-binding protein TDP-43. In this talk I will present findings from new transgenic TDP-43 mouse models, which recapitulate disease-reminiscent pathology, neurodegeneration and behavioural phenotypes. Importantly, I will show that halting TDP-43 accumulation allows neuron survival and functional recovery even at advanced stages of disease, suggesting that similar strategies could be beneficial in patients. I will also describe recent high-coverage quantitative proteomics studies, which have revealed potential new therapeutic targets for the treatment of TDP-43-associated diseases.
About Neuroscience Seminars
Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.
Seminars in the QBI Auditorium are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details.
