Coulson publications
Edwards, Stephen R., Khan, Nemat, Coulson, Elizabeth J. and Smith, Maree T. (2020). Comparative studies of glial fibrillary acidic protein and brain‐derived neurotrophic factor expression in two transgenic mouse models of Alzheimer’s disease. Clinical and Experimental Pharmacology and Physiology 1440-1681.13363 doi: 10.1111/1440-1681.13363
Kumar, Vinod, Lee, John D., Coulson, Elizabeth J. and Woodruff, Trent M. (2020). A validated quantitative method for the assessment of neuroprotective barrier impairment in neurodegenerative disease models. Journal of Neurochemistry jnc.15119 doi: 10.1111/jnc.15119
Qin, Zuoheng, Gonsalvez, David G., Wood, Rhiannon J., Daemi, Fatemeh, Yoo, Sangwon, Ivanusic, Jason J., Coulson, Elizabeth J., Murray, Simon S. and Xiao, Junhua (2020). Partial deletion of p75NTR in large-diameter DRG neurons exerts no influence upon the survival of peripheral sensory neurons in vivo. Journal of Neuroscience Research jnr.24665 doi: 10.1002/jnr.24665
Groves, Natalie, O’Keeffe, Imogen, Lee, Wendy, Toft, Alexandra, Blackmore, Daniel, Bandhavkar, Saurabh, Coulson, Elizabeth J., Bartlett, Perry F. and Jhaveri, Dhanisha J. (2020). Blockade of TrkB but not p75 NTR activates a subpopulation of quiescent neural precursor cells and enhances neurogenesis in the adult mouse hippocampus. Developmental Neurobiology, 79 (9-10) dneu.22729, 868-879. doi: 10.1002/dneu.22729
Meier, Sonja, Alfonsi, Fabienne, Kurniawan, Nyoman D., Milne, Michael R., Kasherman, Maria A., Delogu, Alessio, Piper, Michael and Coulson, Elizabeth J. (2019). The p75 neurotrophin receptor is required for the survival of neuronal progenitors and normal formation of the basal forebrain, striatum, thalamus and neocortex. Development, 146 (18) dev181933, dev.181933. doi: 10.1242/dev.181933
Martínez-Mármol, Ramón, Mohannak, Nika, Qian, Lei, Wang, Tong, Gormal, Rachel S, Ruitenberg, Marc J, Vanhaesebroeck, Bart, Coulson, Elizabeth J and Meunier, Frédéric A (2019). p110δ PI 3-kinase inhibition perturbs APP and TNFα trafficking, reduces plaque burden, dampens neuroinflammation and prevents cognitive decline in an Alzheimer's disease mouse model. Journal of Neuroscience, 39 (40), 7976-7991. doi: 10.1523/JNEUROSCI.0674-19.2019
Ultrafast fMRI of the rodent brain using simultaneous multi-slice EPI
Lee, Hsu-Lei, Li, Zengmin, Coulson, Elizabeth J. and Chuang, Kai-Hsiang (2019). Ultrafast fMRI of the rodent brain using simultaneous multi-slice EPI. NeuroImage, 195, 48-58. doi: 10.1016/j.neuroimage.2019.03.045
Peripheral Nerve Regeneration Is Independent From Schwann Cell p75(NTR) Expression
Goncalves, Nadia P., Mohseni, Simin, El Soury, Marwa, Ulrichsen, Maj, Richner, Mette, Xiao, Junhua, Wood, Rhiannon J., Andersen, Olav M., Coulson, Elizabeth J., Raimondo, Stefania, Murray, Simon S. and Vaegter, Christian B. (2019). Peripheral Nerve Regeneration Is Independent From Schwann Cell p75(NTR) Expression. Frontiers in Cellular Neuroscience, 13 235, 235. doi: 10.3389/fncel.2019.00235
Milne, Michael R., Qian, Lei, Turnbull, Marion T., Kinna, Genevieve, Collins, Brett M., Teasdale, Rohan D. and Coulson, Elizabeth J. (2019). Downregulation of SNX27 expression does not exacerbate amyloidogenesis in the APP/PS1 Alzheimer's disease mouse model. Neurobiology of Aging, 77, 144-153. doi: 10.1016/j.neurobiolaging.2019.01.011
Boskovic, Zoran, Meier, Sonja, Wang, Yunpeng, Milne, Michael R., Onraet, Tessa, Tedoldi, Angelo and Coulson, Elizabeth J. (2019). Regulation of cholinergic basal forebrain development, connectivity, and function by neurotrophin receptors. Neuronal Signaling, 3 (1), NS20180066. doi: 10.1042/ns20180066
Turnbull, Marion T. and Coulson, Elizabeth J. (2017) Cholinergic basal forebrain lesion decreases neurotrophin signaling without affecting tau hyperphosphorylation in genetically susceptible mice. Journal of Alzheimer's Disease,55 3: 1141-1154. doi:10.3233/JAD-160805
Wang, Tong, Martin, Sally, Nguyen, Tam H., Harper, Callista B., Gormal, Rachel S., Martinez-Marmol, Ramon, Karunanithi, Shanker, Coulson, Elizabeth J., Glass, Nick R., Cooper-White, Justin J., Van Swinderen, Bruno and Meunier, Frederic A. (2016) Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB. Nature Communications, 7 . doi:10.1038/ncomms12976
Matusica, Dusan, Alfonsi, Fabienne, Turner, Bradley J., Butler, Tim J., Shepheard, Stephanie R., Rogers, Mary-Louise, Skeldal, Sune, Underwood, Clare K., Mangelsdorf, Marie and Coulson, Elizabeth J. (2016) Inhibition of motor neuron death in vitro and in vivo by a p75 neurotrophin receptor intracellular domain fragment. Journal of Cell Science, 129 3: 517-530. doi:10.1242/jcs.173864
Coulson, Elizabeth J. and Andersen, Olav M. (2015) The A-B-C for SORting APP. Journal of Neurochemistry, 135 1: 1-3. doi:10.1111/jnc.13231
Kerbler, Georg M., Nedelska, Zuzana, Fripp, Jurgen, Laczo, Jan, Vyhnalek, Martin, Lisy, Jiri, Hamlin, Adam S., Rose, Stephen, Hort, Jakub and Coulson, Elizabeth J. (2015) Basal forebrain atrophy contributes to allocentric navigation impairment in Alzheimer's disease patients. Frontiers in Aging Neuroscience, 7 185: 1-11. doi:10.3389/fnagi.2015.00185
Basal forebrain atrophy correlates with amyloid beta burden in Alzheimer's disease
Kerbler, Georg M., Fripp, Jürgen, Rowe, Christopher C., Villemagne, Victor L., Salvado, Olivier, Rose, Stephen, Coulson, Elizabeth J. and Alzheimer's Disease Neuroimaging Initiative (2015) Basal forebrain atrophy correlates with amyloid beta burden in Alzheimer's disease. NeuroImage: Clinical, 7 105-113. doi:10.1016/j.nicl.2014.11.015
Edwards, Stephen R., Hamlin, Adam S., Marks, Nicola, Coulson, Elizabeth J. and Smith, Maree T. (2014) Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models Of Alzheimer's disease. Clinical and Experimental Pharmacology and Physiology, 41 10: 798-806. doi:10.1111/1440-1681.12277
The role of p75NTR in cholinergic basal forebrain structure and function
Boskovic, Zoran, Alfonsi, Fabienne, Rumballe, Bree A., Fonseka, Sachini, Windels, Francois and Coulson, Elizabeth J. (2014) The role of p75NTR in cholinergic basal forebrain structure and function. Journal of Neuroscience, 34 39: 13033-13038. doi:10.1523/JNEUROSCI.2364-14.2014
Matusica, Dusan and Coulson, Elizabeth J. (2014) Local versus long-range neurotrophin receptor signalling: Endosomes are not just carriers for axonal transport. Seminars in Cell and Developmental Biology, 31 57-63. doi:10.1016/j.semcdb.2014.03.032
A role for SNAREs in neuronal survival?
Harper, Callista B., Bademosi, Adekunle T., Coulson, Elizabeth J. and Meunier, Frederic A. (2014) A role for SNAREs in neuronal survival?. Journal of Neurochemistry, 129 5: 753-755. doi:10.1111/jnc.12699
Hort, J., Andel, R., Mokrisova, I., Gazova, I., Amlerova, J., Valis, M., Coulson, E. J., Harrison, J., Windisch, M. and Laczo, J. (2014) Effect of donepezil in alzheimer disease can be measured by a computerized human analog of the morris water maze. Neurodegenerative Diseases, 13 2-3: 192-196. doi:10.1159/000355517
Spatial navigation in young versus older adults
Gazova, Ivana, Laczo, Jan, Rubinova, Eva, Mokrisova, Ivana, Hyncicova, Eva, Andel, Ross, Vyhnalek, Martin, Sheardova, Katerina, Coulson, Elizabeth J. and Hort, Jakub (2013) Spatial navigation in young versus older adults.Frontiers in Aging Neuroscience, 5 DEC: 94.1-94.8. doi:10.3389/fnagi.2013.00094
Up-regulation of sortilin mediated by amyloid-beta and p75NTR: safety lies in the middle course
Coulson, Elizabeth J and Nykjaer, Anders (2013) Up-regulation of sortilin mediated by amyloid-beta and p75NTR: safety lies in the middle course. Journal of Neurochemistry, 127 2: 149-151. doi:10.1111/jnc.12389
Matusica, Dusan, Skeldal, Sune, Sykes, Alex M., Palstra, Nickless, Sharma, Aanchal and Coulson, Elizabeth J. (2013) An intracellular domain fragment of the p75 neurotrophin receptor (p75 NTR) enhances tropomyosin receptor kinase A(TrkA) receptor function. Journal of Biological Chemistry, 288 16: 11144-11154. doi:10.1074/jbc.M112.436469
Martin, Sally, Harper, Callista B., May, Linda M., Coulson, Elizabeth J., Meunier, Frederic A. and Osborne, Shona L. (2013) Inhibition of PIKfyve by YM-201636 Dysregulates Autophagy and Leads to Apoptosis-Independent Neuronal Cell Death. PLoS One, 8 3: e60152.1-e60152.14. doi:10.1371/journal.pone.0060152
Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins
Ghai, Rajesh, Bugarcic, Andrea, Liu, Huadong, Norwood, Suzanne J., Skeldal, Sune, Coulson, Elizabeth J., Li, Shawn Shun-Cheng, Teasdale, Rohan D. and Collins, Brett M. (2013) Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proceedings of the National Academy of Sciences of the United States of America, 110 8: E643-E652. doi:10.1073/pnas.1216229110
Lesions of the basal forebrain cholinergic system in mice disrupt idiothetic navigation
Hamlin, Adam S., Windels, Francois, Boskovic, Zoran, Sah, Pankaj and Coulson, Elizabeth J. (2013) Lesions of the basal forebrain cholinergic system in mice disrupt idiothetic navigation. PLoS ONE, 8 1: e53472.1-e53472.9. doi:10.1371/journal.pone.0053472
Sykes, Alex M., Palstra, Nick, Abankwa, Daniel, Hill, Justine M., Skeldal, Sune, Matusica, Dusan, Venkatraman, Prahatha, Hancock, John F. and Coulson, Elizabeth J. (2012) The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretase. Journal of Biological Chemistry, 287 52: 43810-43824. doi:10.1074/jbc.M112.382903
Kerbler, Georg M., Hamlin, Adam S., Pannek, Kerstin, Kurniawan, Nyoman D., Keller, Marianne D., Rose, Stephen E. and Coulson, Elizabeth J. (2012) Diffusion-weighted magnetic resonance imaging detection of basal forebrain cholinergic degeneration in a mouse model. NeuroImage, 133-141. doi:10.1016/j.neuroimage.2012.10.075
Skeldal, Sune, Sykes, Alex M., Glerup, Simon, Matusica, Dusan, Palstra, Nickless, Autio, Henri, Boskovic, Zoran, Madsen, Peder, Castrén, Eero, Nykjaer, Anders and Coulson, Elizabeth J. (2012) Mapping of the interaction site between sortilin and the p75 neurotrophin receptor reveals a regulatory role for the sortilin intracellular domain in p75 neurotrophin receptor shedding and apoptosis. Journal of Biological Chemistry, 287 52: 43798-43809. doi:10.1074/jbc.M112.374710
Skeldal, Sune, Matusica, Dusan, Nykjaer, Anders and Coulson, Elizabeth J. (2011) Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?: Neuronal life, growth and death signalling are crucially regulated by intra-membrane proteolysis and trafficking of p75(NTR). BioEssays, 33 8: 614-625. doi:10.1002/bies.201100036
Proctor, Dustin T., Coulson, Elizabeth J. and Dodd, Peter R. (2011) Post-synaptic scaffolding protein interactions with glutamate receptors in synaptic dysfunction and Alzheimer's disease. Progress in Neurobiology, 93 4: 509-521. doi:10.1016/j.pneurobio.2011.02.002
Proctor, Dustin T., Coulson, Elizabeth J. and Dodd, Peter R. (2010) Reduction in post-synaptic scaffolding PSD-95 and SAP-102 protein levels in the Alzheimer inferior temporal cortex is correlated with disease pathology. Journal of Alzheimer's Disease, 21 3: 795-811. doi:10.3233/JAD-2010-100090
Aβ₁₋₄₂ stimulates adult SVZ neurogenesis through the p75 neurotrophin receptor
Sotthibundhu, Areechun, Li, Qiao-Xin, Thangnipon, Wipawan and Coulson, Elizabeth J. (2009) Aβ₁₋₄₂ stimulates adult SVZ neurogenesis through the p75 neurotrophin receptor. Neurobiology of Aging, 30 12: 1975-1985. doi:10.1016/j.neurobiolaging.2008.02.004
p75 neurotrophin receptor regulates basal and fluoxetine-stimulated hippocampal neurogenesis
Colditz, Michael J., Catts, Vibeke S., Al-menhali, Noura, Osborne, Geoffrey W., Bartlett, Perry F. and Coulson, Elizabeth J. (2009) p75 neurotrophin receptor regulates basal and fluoxetine-stimulated hippocampal neurogenesis.Experimental Brain Research, 200 2: 161-167. doi:10.1007/s00221-009-1947-6
The role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease
Coulson, Elizabeth, May, Linda, Sykes, Alexander and Hamlin, Adam (2009) The role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease. Neuroscientist, 15 4: 317-323. doi:10.1177/1073858408331376
The p75 neurotrophin receptor regulates hippocampal neurogenesis and related behaviours
Catts, Vibeke, Al-Minhali, Noura, Burne, Thomas H.J., Colditz, Michael and Coulson, Elizabeth (2008) The p75 neurotrophin receptor regulates hippocampal neurogenesis and related behaviours. European Journal of Neuroscience, 28 5: 883-892. doi:10.1111/j.1460-9568.2008.06390.x
β-amyloid1-42 induces neuronal death through the p75 neurotrophin receptor
Sotthibundhu, Areechun, Sykes, Alex M., Fox, Briony, Underwood, Clare K., Thangnipon, Wipawan and Coulson, Elizabeth, J. (2008) β-amyloid1-42 induces neuronal death through the p75 neurotrophin receptor. The Journal of Neuroscience, 28 15: 3941-3946. doi:10.1523/JNEUROSCI.0350-08.2008
Underwood, Clare K., Reid, Kate, May, Linda M., Bartlett, Perry F. and Coulson, Elizabeth J. (2008) Palmitoylation of the C-terminal fragment of p75NTR regulates death signaling and is required for subsequent cleavage by gamma-secretase. Molecular and Cellular Neuroscience, 37 2: 346-358. doi:10.1016/j.mcn.2007.10.005
Coulson, E. J., May, L. M., Osborne, S. L., Reid, K., Underwood, C. K., Meunier, F. A., Bartlett, P. F. and Sah, P. (2008) p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate. Journal of Neuroscience, 28 1: 315-324. doi:10.1523/JNEUROSCI.2699-07.2008
Underwood, Clare K. and Coulson, Elizabeth J. (2008) The p75 neurotrophin receptor. The International Journal of Biochemistry and Cell Biology, 40 9: 1664-1668. doi:10.1016/j.biocel.2007.06.010
Copper induced oxidation of serotonin: analysis of products and toxicity
Jones, C. E., Underwood, C. K., Coulson, E. J. and Taylor, P. J. (2007) Copper induced oxidation of serotonin: analysis of products and toxicity. Journal of Neurochemistry, 102 4: 1035-1043. doi:10.1111/j.1471-4159.2007.04602.x
Zinc-mediated neuronal death is dependent on Trk activation
Morley, Samuel N., Power, John M., Coulson, Elizabeth J. and Bartlett, Perry F. (2007) Zinc-mediated neuronal death is dependent on Trk activation. Experimental Neurology, 205 2: 360-366. doi:10.1016/j.expneurol.2007.02.006
Young, K. M., Merson, T. D., Sotthibundhu, A., Coulson, E. J. and Bartlett, P. F. (2007) p75 Neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells. Journal of Neuroscience, 27 19: 5146-5155. doi:10.1523/JNEUROSCI.0654-07.2007
Apoptosis and schizophrenia: a pilot study based on dermal fibroblast cell lines
Catts, Vibeke Sorensen, Catts, Stanley Victor, McGrath, John Joseph, Feron, Francois, McLean, Duncan, Coulson, Elizabeth Jane and Lutze-Mann, Louise Helen (2006) Apoptosis and schizophrenia: a pilot study based on dermal fibroblast cell lines. Schizophrenia Research, 84 1: 20-28. doi:10.1016/j.schres.2006.03.016
Does the p75 neurotrophin receptor mediate A beta-induced toxicity in Alzheimer's disease?
Coulson, Elizabeth J. (2006) Does the p75 neurotrophin receptor mediate A beta-induced toxicity in Alzheimer's disease?. Journal of Neurochemistry, 98 3: 654-660. doi:10.1111/j.1471-4159.2006.03905.x
Young, Kaylene M., Bartlett, Perry F. and Coulson, Elizabeth J. (2006) Neural progenitor number is regulated by nuclear factor-kappa B p65 and p50 subunit-dependent proliferation rather than cell survival. Journal of Neuroscience Research, 83 1: 39-49. doi:10.1002/jnr.20702
Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner
Kanjhan, R., Coulson, E. J., Adams, D. J. and Bellingham, M. C. (2005) Tertiapin-Q blocks recombinant and native large conductance K+ channels in a use-dependent manner. Journal of Pharmacology And Experimental Therapeutics,314 3: 1353-1361. doi:10.1124/jpet.105.085928
A microarray study of post-mortem mRNA degradation in mouse brain tissue
Catts, V. S., Catts, S. V., Fernandez, H. R., Taylor, J. M., Coulson, E. J. and Lutze-Mann, L. H. (2005) A microarray study of post-mortem mRNA degradation in mouse brain tissue. Molecular Brain Research, 138 2: 164-177. doi:10.1016/j.molbrainres.2005.04.017
Murray, SS, Bartlett, PF, Lopes, EC, Coulson, EJ, Greferath, U and Cheema, SS (2003) Low-affinity neurotrophin receptor with targeted mutation of exon 3 is capable of mediating the death of axotomized neurons. Clinical And Experimental Pharmacology And Physiology, 30 4: 217-222. doi:10.1046/j.1440-1681.2003.03827.x
Jabbour, AM, Ekert, PG, Coulson, EJ, Knight, MJ, Ashley, DM and Hawkins, CJ (2002) The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis. Cell Death And Differentiation,9 12: 1311-1320. doi:10.1038/sj.cdd.4401135
Lowry, KS, Murray, SS, Coulson, EJ, Epa, R, Bartlett, PF, Barrett, G and Cheema, SS (2001) Systemic administration of antisense p75(NTR) oligodeoxynucleotides rescues axotomised spinal motor neurons. Journal of Neuroscience Research, 64 1: 11-17. doi:10.1002/jnr.1048
Chopper, a new death domain of the p75 neurotrophin receptor that mediates rapid neuronal cell death
Coulson, E. J., Reid, K., Baca, M., Shipham, K. A., Hulett, S. M., Kilpatrick, T. J. and Bartlett, P. F. (2000) Chopper, a new death domain of the p75 neurotrophin receptor that mediates rapid neuronal cell death. Journal of Biological Chemistry, 275 39: 30537-30545. doi:10.1074/jbc.M005214200
Role of neurotrophin receptor p75NTR in mediating neuronal cell death following injury
Coulson, E. J., Reid, K., Murray, S. S., Cheema, S. S. and Bartlett, P. F. (2000) Role of neurotrophin receptor p75NTR in mediating neuronal cell death following injury. Clinical And Experimental Pharmacology And Physiology, 27 7: 537-541. doi:10.1046/j.1440-1681.2000.03295.x
What the evolution of the amyloid protein precursor supergene family tells us about its function
Coulson, EJ, Paliga, K, Beyreuther, K and Masters, CL (2000) What the evolution of the amyloid protein precursor supergene family tells us about its function. Neurochemistry International, 36 3: 175-184. doi:10.1016/S0197-0186(99)00125-4
Signaling of neuronal cell death by the p75NTR neurotrophin receptor
Coulson, E. J., Reid, K. and Bartlett, P. F. (1999) Signaling of neuronal cell death by the p75NTR neurotrophin receptor. Molecular Neurobiology, 20 1: 29-44. doi:10.1007/BF02741363
p75 neurotrophin receptor-mediated neuronal death is promoted by Bcl-2 and prevented by Bcl-x(L)
Coulson, E. J., Reid, K., Barrett, G. L. and Bartlett, P. F. (1999) p75 neurotrophin receptor-mediated neuronal death is promoted by Bcl-2 and prevented by Bcl-x(L). Journal of Biological Chemistry, 274 23: 16387-16391. doi:10.1074/jbc.274.23.16387
Uren, AG, Coulson, EJ and Vaux, DL (1998) Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts. Trends In Biochemical Sciences, 23 5: 159-162. doi:10.1016/S0968-0004(98)01198-0
Epa, WR, Rong, P, Bartlett, PF, Coulson, EJ and Barrett, GL (1998) Enhanced downregulation of the p75 nerve growth factor receptor by cholesteryl and bis-cholesteryl antisense oligonucleotides. Antisense & Nucleic Acid Drug Development, 8 6: 489-498. doi:10.1089/oli.1.1998.8.489
Coulson, EJ, Barrett, GL, Storey, E, Bartlett, PF, Beyreuther, K and Masters, CL (1997) Down-regulation of the amyloid protein precursor of Alzheimer's disease by antisense oligonucleotides reduces neuronal adhesion to specific substrata. Brain Research, 770 1-2: 72-80. doi:10.1016/S0006-8993(97)00757-9