Speaker: Dr. Sabine Krabbe
Group Leader
Functional Diversity of Neural Circuits
Deutsches Zentrum für Neurodegenerative Erkrankungen e. V. (DZNE)
Functional diversity of amygdala microcircuits
Abstract: Neural circuits adapt through plasticity to support memory, yet the specific contributions of inhibitory interneurons remain unclear. I will present recent work using deep-brain calcium imaging to track genetically-defined amygdala interneurons in freely moving mice during fear learning and extinction, enabling single cell-level analysis across memory acquisition, expression, and updating. Our results reveal diverse interneuron dynamics linked to both external cues and internal states, highlighting flexible inhibitory mechanisms within amygdala microcircuits. I will also touch on how such mechanisms may interface with exploration-related processes, through which animals reduce environmental uncertainty, and how neuromodulatory signals supporting information-seeking may converge on these circuits to shape adaptive learning.
About Neuroscience Seminars
Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.
Seminars in the QBI Auditorium on Level 7 are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details.
