Group Leader
Our research
The Dehorter Lab investigates the molecular and cellular mechanisms that govern brain development, neural circuit function, and neurological disease. Their focus is on how alterations in key molecular regulators contribute to neurodevelopmental and neurodegenerative disorders, including autism spectrum disorder, schizophrenia, and Parkinson's disease.
Using a multidisciplinary approach, the lab combine state-of-the-art molecular biology, genetics, in vitro and in vivo imaging, electrophysiology, and behavioural analysis to study how neurons develop, adapt, and communicate within complex brain circuits. Ultimately, this work seeks to inform strategies that restore normal brain activity, improve cognitive and behavioural outcomes, and enhance quality of life for people affected by neurological and psychiatric disorders.
Research focus
Understanding the molecular programs that generate and maintain the remarkable diversity of inhibitory interneurons in the mammalian brain, and how this diversity contributes to neural circuit formation, sensory processing, and behaviour.
Neuronal adaptation & circuit balance
Investigating how neurons adjust their activity in response to changing environmental and network demands to maintain stable brain function, learning, and cognitive flexibility.
Mechanisms of brain disorders
Determining how disruptions to molecular signalling pathways and neuronal communication contribute to neurodevelopmental and neurodegenerative conditions, with a focus on identifying targets for future therapeutic development.
Latest News
- 18 June 2025