Dr Gerhard Leinenga
Postdoctoral Research Fellow
Queensland Brain Institute
+61 7 334 66326
Journal Articles
Leinenga, Gerhard, Koh, Wee Kiat and Götz, Jürgen (2019) Scanning ultrasound in the absence of blood-brain barrier opening is not sufficient to clear β-amyloid plaques in the APP23 mouse model of Alzheimer's disease. Brain Research Bulletin, 153 8-14. doi:10.1016/j.brainresbull.2019.08.002
Janowicz, Phillip W., Leinenga, Gerhard, Götz, Jürgen and Nisbet, Rebecca M. (2019) Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody. Scientific Reports, 9 1: 9255. doi:10.1038/s41598-019-45577-2
Pandit, Rucha, Leinenga, Gerhard and Gotz, Jurgen (2019) Repeated ultrasound treatment of tau transgenic mice clears neuronal tau by autophagy and improves behavioral functions. Theranostics, 9 13: 3754-3767. doi:10.7150/thno.34388
Odabaee, Maryam, Odabaee, Mostafa, Pelekanos, Matthew, Leinenga, Gerhard and Götz, Jürgen (2018) Modeling ultrasound propagation through material of increasing geometrical complexity. Ultrasonics, 90 52-62. doi:10.1016/j.ultras.2018.05.014
Leinenga, Gerhard and Gotz, Jurgen (2018) Safety and Efficacy of Scanning Ultrasound Treatment of Aged APP23 Mice. Frontiers in Neuroscience, 12 FEB: 1-10. doi:10.3389/fnins.2018.00055
Pelekanos, Matthew, Leinenga, Gerhard, Odabaee, Mostafa, Odabaee, Maryam, Saifzadeh, Siamak, Steck, Roland and Götz, Jürgen (2018) Establishing sheep as an experimental species to validate ultrasound-mediated blood-brain barrier opening for potential therapeutic interventions. Theranostics, 8 9: 2583-2602. doi:10.7150/thno.22852
Leinenga, Gerhard, Nisbet, Rebecca M. and Gotz, Jurgen (2017) Ultrasound as a treatment modality for neurological diseases. Medical Journal of Australia, 206 11: 470-471. doi:10.5694/mja16.01013
Nisbet, Rebecca M., Van der Jeugd, Ann, Leinenga, Gerhard, Evans, Harrison T., Janowicz, Phillip W. and Goetz, Juergen (2017) Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model. Brain, 140 5: 1220-1230. doi:10.1093/brain/awx052
Hatch, Robert John, Leinenga, Gerhard and Götz, Jürgen (2016) Scanning ultrasound (SUS) causes no changes to neuronal excitability and prevents age-related reductions in hippocampal CA1 dendritic structure in wild-type mice. PloS One, 11 10: e0164278. doi:10.1371/journal.pone.0164278
Gerhard Leinenga, Langton, Christian, Rebecca Nisbet and Juergen Goetz (2016) Ultrasound treatment of neurological diseases — current and emerging applications. Nature Reviews Neurology, 12 3: 161-174.doi:10.1038/nrneurol.2016.13
Gerhard Leinenga and Juergen Goetz (2015) Scanning ultrasound removes amyloid-beta and restores memory in an Alzheimer's disease mouse model. Science Translational Medicine, 7 278: 278ra33.1-278ra33.12.doi:10.1126/scitranslmed.aaa2512
Goetz, Juergen, Xia, Di, Leinenga, Gerhard, Chew, Yee Lian and Nicholas, Hannah R. (2013) What renders TAU toxic. Frontiers in Neurology, 4 72.1-72.10. doi:10.3389/fneur.2013.00072
Conference Papers
Götz, Jürgen, Nisbet, Rebecca, Van der Jeugd, Ann, Evans, Harrison and Leinenga, Gerhard (2016). Scanning ultrasound as a treatment tool of proteinopathies including Alzheimer’s disease. In: 5th International Symposium on Focused Ultrasound, Bethesda, MD, USA, (4-4). 28 August - 1 September 2016. doi:10.1186/s40349-016-0076-5
Leinenga, Gerhard, Nisbet, Rebecca, Hatch, Robert, Van der Jeugd, Anneke, Evans, Harrison and Götz, Jürgen (2016). Scanning Focused Ultrasound disruption of the blood-brain barrier as an Alzheimer’s disease therapy. In: 5th International Symposium on Focused Ultrasound, Bethesda, MD, USA, (3-3). 28 August - 1 September 2016. doi:10.1186/s40349-016-0076-5
Leinenga, G. and Goetz, J. (2015). Effects of scanning focused ultrasound in an Alzheimer's mouse model. In: 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian‐Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian‐Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD, Australia, (274-275). 23 - 27 August 2015.
Van der Jeugd, A., Leinenga, G., Nisbet, R. and Goetz, J. (2015). Scanning ultrasound opens blood-brain barrier and improves pathologic abnormalities and behaviour in a mouse model of Alzheimer's. In: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, QLD, Australia, (277-278). 23 - 27 August 2015.
Goetz, J., Nisbet, R., Leinenga, G. and Van der Jeugd, A. (2015). Novel strategies to target tau and Ab toxicity. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (90-90). 23-27 August 2015. doi:10.1111/jnc.13186
Thesis
Leinenga, Gerhard (2017). Investigations of the effects of scanning focused ultrasound in mouse models of Alzheimer’s disease PhD Thesis, Queensland Brain Institute, The University of Queensland. doi:10.14264/uql.2017.467