Dr Gerhard Leinenga
Postdoctoral Research Fellow
Queensland Brain Institute
+61 7 334 66326
Publications
Journal Articles
Leinenga, Gerhard, Padmanabhan, Pranesh and Götz, Jürgen (2024). Improving cognition without clearing amyloid: effects of tau and ultrasound neuromodulation. Journal of Alzheimer's Disease, 100 (s1), S211-S222. doi: 10.3233/jad-240616
Leinenga, Gerhard, To, Xuan Vinh, Bodea, Liviu-Gabriel, Yousef, Jumana, Richter-Stretton, Gina, Palliyaguru, Tishila, Chicoteau, Antony, Dagley, Laura, Nasrallah, Fatima and Götz, Jürgen (2024). Correction: Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction. Molecular Psychiatry, 29 (12), 3968-3970. doi: 10.1038/s41380-024-02616-3
Leinenga, Gerhard, To, Xuan Vinh, Bodea, Liviu-Gabriel, Yousef, Jumana, Richter-Stretton, Gina, Palliyaguru, Tishila, Chicoteau, Antony, Dagley, Laura, Nasrallah, Fatima and Götz, Jürgen (2024). Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction. Molecular Psychiatry, 29 (8), 1-16. doi: 10.1038/s41380-024-02509-5
Leinenga, Gerhard, Bodea, Liviu‐Gabriel, Schröder, Jan, Sun, Giuzhi, Zhou, Yichen, Song, Jae, Grubman, Alexandra, Polo, Jose M. and Götz, Jürgen (2022). Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasound. Bioengineering & Translational Medicine, 8 (1) e10329, e10329. doi: 10.1002/btm2.10329
Chen, Liyu, Sutharsan, Ratneswary, Lee, Jonathan L. F., Cruz, Esteban, Asnicar, Blaise, Palliyaguru, Tishila, Wasielewska, Joanna M., Gaudin, Arnaud, Song, Jae, Leinenga, Gerhard and Götz, Jürgen (2022). Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model. Theranostics, 12 (5), 1952-1970. doi: 10.7150/thno.65539
Wasielewska, Joanna M., Chaves, Juliana C.S., Johnston, Rebecca L., Milton, Laura A., Hernández, Damián, Chen, Liyu, Song, Jae, Lee, Wendy, Leinenga, Gerhard, Nisbet, Rebecca M., Pébay, Alice, Götz, Jürgen, White, Anthony R. and Oikari, Lotta E. (2022). A sporadic Alzheimer’s blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies. Theranostics, 12 (16), 6826-6847. doi: 10.7150/thno.72685
Leinenga, Gerhard, Koh, Wee Kiat and Götz, Jürgen (2021). A comparative study of the effects of Aducanumab and scanning ultrasound on amyloid plaques and behavior in the APP23 mouse model of Alzheimer disease. Alzheimer's Research and Therapy, 13 (1) 76, 1-14. doi: 10.1186/s13195-021-00809-4
Leinenga, Gerhard, Bodea, Liviu-Gabriel, Koh, Wee Kiat, Nisbet, Rebecca M. and Götz, Jürgen (2020). Delivery of antibodies into the brain using focused scanning ultrasound. Journal of Visualized Experiments, 2020 (161) e61372, 1-13. doi: 10.3791/61372
Leinenga, Gerhard, Koh, Wee Kiat and Götz, Jürgen (2019). Scanning ultrasound in the absence of blood-brain barrier opening is not sufficient to clear β-amyloid plaques in the APP23 mouse model of Alzheimer's disease. Brain Research Bulletin, 153, 8-14. doi: 10.1016/j.brainresbull.2019.08.002
Janowicz, Phillip W., Leinenga, Gerhard, Götz, Jürgen and Nisbet, Rebecca M. (2019). Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody. Scientific Reports, 9 (1) 9255, 9255. doi: 10.1038/s41598-019-45577-2
Pandit, Rucha, Leinenga, Gerhard and Gotz, Jurgen (2019). Repeated ultrasound treatment of tau transgenic mice clears neuronal tau by autophagy and improves behavioral functions. Theranostics, 9 (13), 3754-3767. doi: 10.7150/thno.34388
Odabaee, Maryam, Odabaee, Mostafa, Pelekanos, Matthew, Leinenga, Gerhard and Götz, Jürgen (2018). Modeling ultrasound propagation through material of increasing geometrical complexity. Ultrasonics, 90, 52-62. doi: 10.1016/j.ultras.2018.05.014
Leinenga, Gerhard and Gotz, Jurgen (2018). Safety and Efficacy of Scanning Ultrasound Treatment of Aged APP23 Mice. Frontiers in Neuroscience, 12 (FEB) 55, 1-10. doi: 10.3389/fnins.2018.00055
Pelekanos, Matthew, Leinenga, Gerhard, Odabaee, Mostafa, Odabaee, Maryam, Saifzadeh, Siamak, Steck, Roland and Götz, Jürgen (2018). Establishing sheep as an experimental species to validate ultrasound-mediated blood-brain barrier opening for potential therapeutic interventions. Theranostics, 8 (9), 2583-2602. doi: 10.7150/thno.22852
Leinenga, Gerhard, Nisbet, Rebecca M. and Gotz, Jurgen (2017). Ultrasound as a treatment modality for neurological diseases. Medical Journal of Australia, 206 (11), 470-471. doi: 10.5694/mja16.01013
Nisbet, Rebecca M., Van der Jeugd, Ann, Leinenga, Gerhard, Evans, Harrison T., Janowicz, Phillip W. and Goetz, Juergen (2017). Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model. Brain, 140 (5), 1220-1230. doi: 10.1093/brain/awx052
Hatch, Robert John, Leinenga, Gerhard and Götz, Jürgen (2016). Scanning ultrasound (SUS) causes no changes to neuronal excitability and prevents age-related reductions in hippocampal CA1 dendritic structure in wild-type mice. PloS One, 11 (10) e0164278, e0164278. doi: 10.1371/journal.pone.0164278
Leinenga, Gerhard, Langton, Christian, Nisbet, Rebecca and Gotz, Jurgen (2016). Ultrasound treatment of neurological diseases — current and emerging applications. Nature Reviews Neurology, 12 (3), 161-174. doi: 10.1038/nrneurol.2016.13
Leinenga, Gerhard and Götz, Jürgen (2015). Scanning ultrasound removes amyloid-beta and restores memory in an Alzheimer's disease mouse model. Science Translational Medicine, 7 (278) 278ra33, 278ra33.1-278ra33.12. doi: 10.1126/scitranslmed.aaa2512
Goetz, Juergen, Xia, Di, Leinenga, Gerhard, Chew, Yee Lian and Nicholas, Hannah R. (2013). What renders TAU toxic. Frontiers in Neurology, 4 Article 72, 72.1-72.10. doi: 10.3389/fneur.2013.00072
Conference Papers
Götz, Jürgen, Nisbet, Rebecca, Van der Jeugd, Ann, Evans, Harrison and Leinenga, Gerhard (2016). Scanning ultrasound as a treatment tool of proteinopathies including Alzheimer’s disease. 5th International Symposium on Focused Ultrasound, Bethesda, MD, USA, 28 August - 1 September 2016. London, United Kingdom: BioMed Central. doi: 10.1186/s40349-016-0076-5
Leinenga, Gerhard, Nisbet, Rebecca, Hatch, Robert, Van der Jeugd, Anneke, Evans, Harrison and Götz, Jürgen (2016). Scanning Focused Ultrasound disruption of the blood-brain barrier as an Alzheimer’s disease therapy. 5th International Symposium on Focused Ultrasound, Bethesda, MD United States, 28 August - 1 September 2016. London, United Kingdom: BioMed Central. doi: 10.1186/s40349-016-0076-5
Leinenga, G. and Goetz, J. (2015). Effects of scanning focused ultrasound in an Alzheimer's mouse model. 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian‐Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD, Australia, 23 - 27 August 2015. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing.
Van der Jeugd, A., Leinenga, G., Nisbet, R. and Goetz, J. (2015). Scanning ultrasound opens blood-brain barrier and improves pathologic abnormalities and behaviour in a mouse model of Alzheimer's. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, QLD, Australia, 23 - 27 August 2015. West Sussex, United Kingdom: Wiley-Blackwell Publishing.
Goetz, J., Nisbet, R., Leinenga, G. and Van der Jeugd, A. (2015). Novel strategies to target tau and Ab toxicity. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, 23-27 August 2015. Chichester, West Sussex, United Kingdom Publisher: Wiley-Blackwell Publishing. doi: 10.1111/jnc.13186
Preprint
Thesis
Leinenga, Gerhard (2017). Investigations of the effects of scanning focused ultrasound in mouse models of Alzheimer’s disease. PhD Thesis, Queensland Brain Institute, The University of Queensland. doi: 10.14264/uql.2017.467
Data Collections
Leinenga, Gerhard, Richter-Stretton, Gina, To, Xuan Vinh, Chicoteau, Antony, Lee, Wendy and Götz, Jürgen (2024). Scanning ultrasound-mediated improvements in APP23 mice. The University of Queensland. (Dataset) doi: 10.48610/2ca0cbe
Leinenga, Gerhard, Richter-Stretton, Gina, To, Xuan Vinh and Götz, Jürgen (2024). Scanning ultrasound-mediated improvements in APP23 mice in vivo imaging. The University of Queensland. (Dataset) doi: 10.48610/0239687