Sah research
Synaptic Plasticity in Practice
The Sah Laboratory investigates how changes at the synaptic level shape neural communication and circuit function. By examining how signals are transmitted between neurons, the team identifies the cellular processes that influence how information is encoded within brain networks.
To achieve this, the laboratory integrates:
- Electrophysiological recordings to measure real-time neuronal activity
- Molecular approaches to examine the properties of synaptic connections
- Behavioural paradigms to link neural activity with observable outcomes
This combined approach allows the team to directly measure how synapses function within defined circuits.
Experimental Models of Emotional Learning
A key experimental focus is the use of fear conditioning models to study associative learning. These models provide a controlled framework to investigate how the brain links sensory cues with emotionally significant events.
Within this context, the amygdala serves as a central processing hub. The lab examines how distinct nuclei within the amygdala contribute to encoding and storing learned associations, and how these signals influence behavioural responses.
Dissecting Neural Circuits
The group applies optogenetics to selectively control neuron populations and test how specific pathways contribute to learning processes.
In parallel, acute brain slice recordings are used to characterise synaptic connections at high resolution. These experiments focus on:
- Inputs conveying sensory information
- Pathways transmitting aversive or threat-related signals
- Interactions between the amygdala, prefrontal cortex, and hippocampus
By mapping these pathways, the team builds a detailed picture of how distributed brain networks coordinate complex behaviours.
Human Brain Recording and Neuromodulation
To extend these findings beyond the laboratory, the group conducts electrophysiological recordings during deep brain stimulation (DBS)
These recordings provide rare access to real-time human brain activity, offering insight into the neural dynamics underlying movement and neuropsychiatric disorders. This work highlights the potential of targeted brain stimulation to modulate dysfunctional circuits.