The Dehorter Group aims to determine how interneurons shape neuronal networks activity and contribute to circuits balance in health and disease.
While early genetic specification seems to drive the cardinal properties of the interneurons, it is increasingly recognized that their final features are subject to regulation by experience. We seek to identify genetic programs triggered by neuronal activity that lead to the remarkable diversity of neuronal subclasses.
We want to address fundamental questions:
How do interneurons adapt their activity to the environment and transmit appropriate information to the rest of the neuronal circuit?
How these adaptive processes shape emergent networks and modulate inhibitory circuits in normal condition and in pathology?
Can we detect early signs of interneuron dysfunction in pathologies such as Parkinson’s disease, schizophrenia or autism and restore normal activity to alleviate or block consequent deleterious symptoms?
To achieve our goals, we will take advantage of a multi-disciplinary approach, employing state of the art molecular biology, genetics, in vitro/ in vivo imaging and electrophysiological techniques.
Ahmed, Noorya Yasmin, Knowles, Rhys, Liu, Lixinyu, Yan, Yiming, Li, Xiaohan, Schumann, Ulrike, Wang, Yumeng, Sontani, Yovina, Reynolds, Nathan, Natoli, Riccardo, Wen, Jiayu, Del Pino, Isabel, Mi, Da and Dehorter, Nathalie (2023).Developmental deficits of MGE-derived interneurons in the Cntnap2 knockout mouse model of autism spectrum disorder. Frontiers in Cell and Developmental Biology, 11. doi: 10.3389/fcell.2023.1112062
Barettino, Candela, Ballesteros-Gonzalez, Álvaro, Aylón, Andrés, Soler-Sanchis, Xavier, Ortí, Leticia, Díaz, Selene, Reillo, Isabel, García-García, Francisco, Iborra, Francisco José, Lai, Cary, Dehorter, Nathalie, Leinekugel, Xavier, Flames, Nuria and Del Pino, Isabel (2021).Developmental disruption of Erbb4 in Pet1+ neurons impairs serotonergic sub-system connectivity and memory formation. Frontiers in Cell and Developmental Biology, 9 770458, 1-17. doi: 10.3389/fcell.2021.770458
Knowles, Rhys, Dehorter, Nathalie and Ellender, Tommas (2021).From progenitors to progeny: shaping striatal circuit development and function. The Journal of Neuroscience, 41 (46), 9483-9502. doi: 10.1523/JNEUROSCI.0620-21.2021
Al Abed, A. Shaam, Reynolds, Nathan J. and Dehorter, Nathalie (2021).A second wave for the Neurokinin Tac2 pathway in brain research. Biological Psychiatry, 90 (3), 156-164. doi: 10.1016/j.biopsych.2021.02.016
Ahmed, Noorya Yasmin, Ranjbar-Slamloo, Yadollah, Al Abed, Alice Shaam, Gao, Lingxiao, Sontani, Yovina, RCom-H'cheo-Gauthier, Alexandre, Arabzadeh, Ehsan and Dehorter, Nathalie (2021).Er81 transcription factor fine-tunes striatal cholinergic interneuron activity and drives habit formation. The Journal of Neuroscience, 41 (20), 4392-4409. doi: 10.1523/JNEUROSCI.0967-20.2021
Dehorter, Nathalie and Del Pino, Isabel (2020).Shifting developmental trajectories during critical periods of brain formation. Frontiers in Cellular Neuroscience, 14 283, 1-14. doi: 10.3389/fncel.2020.00283
Ahmed, Noorya Yasmin, Knowles, Rhys and Dehorter, Nathalie (2019).New insights into cholinergic neuron diversity. Frontiers in Molecular Neuroscience, 12 204, 1-12. doi: 10.3389/fnmol.2019.00204
Scott, Ricardo, Sánchez-Aguilera, Alberto, Van Elst, Kim, Lim, Lynette, Dehorter, Nathalie, Bae, Sung Eun, Bartolini, Giorgia, Peles, Elior, Kas, Martien J H, Bruining, Hilgo and Marín, Oscar (2019).Loss of Cntnap2 causes axonal excitability deficits, developmental delay in cortical myelination, and abnormal stereotyped motor behavior. Cerebral Cortex, 29 (2), 586-597. doi: 10.1093/cercor/bhx341
Dehorter, Nathalie, Marichal, Nicolás, Marín, Oscar and Berninger, Benedikt (2017).Tuning neural circuits by turning the interneuron knob. Current Opinion in Neurobiology, 42, 144-151. doi: 10.1016/j.conb.2016.12.009
Dehorter, Nathalie, Ciceri, Gabriele, Bartolini, Giorgia, Lim, Lynette, Del Pino, Isabel and Marín, Oscar (2015).Tuning of fast-spiking interneuron properties by an activity-dependent transcriptional switch. Science, 349 (6253), 1216-1220. doi: 10.1126/science.aab3415
Dehorter, Nathalie and Hammond, Constance (2014).Giant GABAA receptor mediated currents in the striatum, a common signature of Parkinson's disease in pharmacological and genetic rodent models. Basal Ganglia, 3 (4), 197-201. doi: 10.1016/j.baga.2013.10.001
Ciceri, Gabriele and Dehorter, Nathalie (2014).Organization of interneurons lineages in the cerebral cortex Organisation des lignées d'interneurones du cortex cérébral. Medecine/Sciences, 30 (2), 144-146. doi: 10.1051/medsci/20143002010
delPino, Isabel, García-Frigola, Cristina, Dehorter, Nathalie, Brotons-Mas, JorgeR., Alvarez-Salvado, Efrén, MartínezdeLagrán, María, Ciceri, Gabriele, Gabaldón, MaríaVictoria, Moratal, David, Dierssen, Mara, Canals, Santiago, Marín, Oscar and Rico, Beatriz (2013).Erbb4 Deletion from Fast-Spiking Interneurons Causes Schizophrenia-like Phenotypes. Neuron, 79 (6), 1152-1168. doi: 10.1016/j.neuron.2013.07.010
Ciceri, Gabriele, Dehorter, Nathalie, Sols, Ignasi, Huang, Z Josh, Maravall, Miguel and Marín, Oscar (2013).Lineage-specific laminar organization of cortical GABAergic interneurons. Nature Neuroscience, 16 (9), 1199-1210. doi: 10.1038/nn.3485
Dehorter, Nathalie, Lozovaya, Natalia, Julius Mdzomba, B., Michel, François J., Lopez, Catherine, Tsintsadze, Vera, Tsintsadze, Timur, Klinkenberg, Michael, Gispert, Suzanna, Auburger, Georg and Hammond, Constance (2012).Subthalamic lesion or levodopa treatment rescues giant GABAergic currents of PINK1-deficient striatum. Journal of Neuroscience, 32 (50), 18047-18053. doi: 10.1523/JNEUROSCI.2474-12.2012
Dehorter, N., Vinay, L., Hammond, C. and Ben-Ari, Y. (2012).Timing of developmental sequences in different brain structures: Physiological and pathological implications. European Journal of Neuroscience, 35 (12), 1846-1856. doi: 10.1111/j.1460-9568.2012.08152.x
Ferrari, Diana C., Mdzomba, Baya J., Dehorter, Nathalie, Lopez, Catherine, Michel, François J., Libersat, Frédéric and Hammond, Constance (2012).Midbrain dopaminergic neurons generate calcium and sodium currents and release dopamine in the striatum of pups. Frontiers in Cellular Neuroscience (MARCH) 7, 1-9. doi: 10.3389/fncel.2012.00007
Dehorter, Nathalie, Michel, François J., Marissal, Thomas, Rotrou, Yann, Matrot, Boris, Lopez, Catherine, Humphries, Mark D. and Hammond, Constance (2011).Onset of pup locomotion coincides with loss of NR2C/D-mediated cortico-striatal EPSCs and dampening of striatal network immature activity. Frontiers in Cellular Neuroscience (NOVEMBER), 1-14. doi: 10.3389/fncel.2011.00024
Gelman, Diego, Griveau, Amélie, Dehorter, Nathalie, Teissier, Anne, Varela, Carolina, Pla, Ramón, Pierani, Alessandra and Marín, Oscar (2011).A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area. Journal of Neuroscience, 31 (46), 16570-16580. doi: 10.1523/JNEUROSCI.4068-11.2011
Dehorter, Nathalie, Guigoni, Celine, Lopez, Catherine, Hirsch, June, Eusebio, Alexandre, Ben-Ari, Yehezkel and Hammond, Constance (2009).Dopamine-deprived striatal GABAergic interneurons burst and generate repetitive gigantic IPSCs in medium spiny neurons. Journal of Neuroscience, 29 (24), 7776-7787. doi: 10.1523/JNEUROSCI.1527-09.2009
Bouvier, Julien, Autran, Sandra, Dehorter, Nathalie, Katz, David M., Champagnat, Jean, Fortin, Gilles and Thoby-Brisson, Muriel (2008).Brain-derived neurotrophic factor enhances fetal respiratory rhythm frequency in the mouse preBötzinger complex in vitro. European Journal of Neuroscience, 28 (3), 510-520. doi: 10.1111/j.1460-9568.2008.06345.x
- JCSMR Gender Equity Award (2017)
- FENS Travel Grant Milan, Italy
- European Molecular Biology Organization (EMBO) long-term fellowship
- PhD grant from France Parkinson Association
- PhD grant from « région PACA », France
- Consequences of impaired neuronal activity during development in a mouse model of autism
- Molecular Control of the Interneuron Integration and Synapse Formation
- Presymptomatic Signatures of Interneuron Dysfunction in Mice Models of Striatum-Related Pathologies
