Bredy publications

Bridging neurobiological mechanisms and translational applications in cognitive science: inspirations from the MCCS-NYUAD meeting 2025

Nami, Mohammad, Wang, Dan Ohtan, Yoon, Ki-Jun, Wang, Dan Ohtan, Sreedharan, Saji Kumar, Shaker, Mohammed, Raymond, Jennifer, Rokers, Bas, Rosenblum, Kobi, Nami, Mohammad, Melcher, David, Lee, Yong-Seok, Lai, Kwok-On, Kheirbek, Mazen, Kida, Satoshi, Kaang, Bong-Kiun, Inokuchi, Kaoru, Hirase, Hajime, Hayashi, Yasunori, Frankland, Paul, Chaudhury, Dipesh, Bredy, Tim, Banerjee, Sourav, and Abel, Ted (2026). Bridging neurobiological mechanisms and translational applications in cognitive science: inspirations from the MCCS-NYUAD meeting 2025. Molecular Brain 19 (1) 21 1. https://doi.org/10.1186/s13041-026-01281-7

Dynamic regulation of neuronal vault trafficking and RNA cargo by the noncoding RNA, Vaultrc5

Musgrove, Mason R. B., Leighton, Laura J., Lebouc, Margaux, Liau, Wei-Siang, Walsh, Alexander D., Marshall, Paul R., Heyworth, Stephanie M., Bademosi, Adekunle T., Hertrich, Nathalie, Zhao, Qiongyi, Madugalle, Sachithrani U., Periyakaruppiah, Ambika, Li, Xiang, Davies, Joshua W. A., Ren, Haobin, Gong, Hao, Zajaczkowski, Esmi L., Dehorter, Nathalie, Meunier, Frederic, Mikhaylova, Marina, and Bredy, Timothy W. (2026). Dynamic regulation of neuronal vault trafficking and RNA cargo by the noncoding RNA, Vaultrc5. Neurobiology of Learning and Memory 225 108161 1-13. https://doi.org/10.1016/j.nlm.2026.108161

Isoform-level profiling of m6 A epitranscriptomic signatures in human brain

Gleeson, Josie, Madugalle, Sachithrani U., Wan, Ching Yin, McLean, Catriona, Bredy, Timothy W., De Paoli-Iseppi, Ricardo, and Clark, Michael B. (2025). Isoform-level profiling of m6 A epitranscriptomic signatures in human brain. Science Advances 11 (32) eadp0783 1-17. https://doi.org/10.1126/sciadv.adp0783

Noncoding RNA gives agency to the molecular and cellular substrates of learning and memory

Walsh, Alexander D. and Bredy, Timothy W. (2025). Noncoding RNA gives agency to the molecular and cellular substrates of learning and memory. Current Opinion in Neurobiology 93 103044 1-8. https://doi.org/10.1016/j.conb.2025.103044

Cutting-edge RNA technologies to advance the understanding of learning and memory

Davies, Joshua William Ashley, Bredy, Timothy William, and Marshall, Paul Robert (2025). Cutting-edge RNA technologies to advance the understanding of learning and memory. Neurobiology of Learning and Memory 219 108050 108050. https://doi.org/10.1016/j.nlm.2025.108050

DNA G-quadruplex is a transcriptional control device that regulates memory (VOL 12, 1828, 2021)

Marshall, Paul R., Davies, Joshua, Zhao, Qiongyi, Liau, Wei-Siang, Lee, Yujin, Basic, Dean, Periyakaruppiah, Ambika, Zajaczkowski, Esmi L., Leighton, Laura J., Madugalle, Sachithrani U., Musgrove, Mason, Kielar, Marcin, Brueckner, Arie Maeve, Gong, Hao, Ren, Haobin, Walsh, Alexander, Kaczmarczyk, Lech, Jackson, Walker S., Chen, Alon, Spitale, Robert C., and Bredy, Timothy W. (2025). DNA G-quadruplex is a transcriptional control device that regulates memory (VOL 12, 1828, 2021). Journal of Neuroscience 45 (11) e0308252025 . https://doi.org/10.1523/JNEUROSCI.0308-25.2025

DNA G-quadruplex is a transcriptional control device that regulates memory

Marshall, Paul R., Davies, Joshua, Zhao, Qiongyi, Liau, Wei-Siang, Lee, Yujin, Basic, Dean, Periyakaruppiah, Ambika, Zajaczkowski, Esmi L., Leighton, Laura J., Madugalle, Sachithrani U., Musgrove, Mason, Kielar, Marcin, Brueckner, Arie Maeve, Gong, Hao, Ren, Haobin, Walsh, Alexander, Kaczmarczyk, Lech, Jackson, Walker S., Chen, Alon, Spitale, Robert C., and Bredy, Timothy W. (2024). DNA G-quadruplex is a transcriptional control device that regulates memory. The Journal of Neuroscience 44 (15) e0093232024 1-20. https://doi.org/10.1523/jneurosci.0093-23.2024

Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory

Chen, Claire C., Han, Joseph, Chinn, Carlene A., Rounds, Jacob S., Li, Xiang, Nikan, Mehran, Myszka, Marie, Tong, Liqi, Passalacqua, Luiz F. M., Bredy, Timothy, Wood, Marcelo A., and Luptak, Andrej (2024). Inhibition of Cpeb3 ribozyme elevates CPEB3 protein expression and polyadenylation of its target mRNAs, and enhances object location memory. eLife 13 e90116 . https://doi.org/10.7554/elife.90116

Fundamental Neurochemistry Review: At the intersection between the brain and the immune system: Non‐coding RNAs spanning learning, memory and adaptive immunity

Musgrove, Mason R. B., Mikhaylova, Marina, and Bredy, Timothy W. (2024). Fundamental Neurochemistry Review: At the intersection between the brain and the immune system: Non‐coding RNAs spanning learning, memory and adaptive immunity. Journal of Neurochemistry 168 (6) 961-976. https://doi.org/10.1111/jnc.16071

Chronically high stress hormone levels dysregulate sperm long noncoding RNAs and their embryonic microinjection alters development and affective behaviours

Hoffmann, L. B., Li, B., Wei, W., Zhao, Q., Leighton, L. J., Bredy, T. W., Pang, T. Y., and Hannan, A. J. (2023). Chronically high stress hormone levels dysregulate sperm long noncoding RNAs and their embryonic microinjection alters development and affective behaviours. Molecular Psychiatry 29 (3) 590-601. https://doi.org/10.1038/s41380-023-02350-2

Huntingtin decreases susceptibility to a spontaneous seizure disorder in FVN/B mice

Van Raamsdonk, Jeremy M., Al-Shekaili, Hilal H., Wagner, Laura, Bredy, Tim W., Chan, Laura, Pearson, Jacqueline, Schwab, Claudia, Murphy, Zoe, Devon, Rebecca S., Lu, Ge, Kobor, Michael S., Hayden, Michael R., and Leavitt, Blair R. (2023). Huntingtin decreases susceptibility to a spontaneous seizure disorder in FVN/B mice. Aging and Disease 14 (6) 2249-2266. https://doi.org/10.14336/AD.2023.0423

Fear extinction is regulated by the activity of long noncoding RNAs at the synapse

Liau, Wei-Siang, Zhao, Qiongyi, Bademosi, Adekunle, Gormal, Rachel S., Gong, Hao, Marshall, Paul R., Periyakaruppiah, Ambika, Madugalle, Sachithrani U., Zajaczkowski, Esmi L., Leighton, Laura J., Ren, Haobin, Musgrove, Mason, Davies, Joshua, Rauch, Simone, He, Chuan, Dickinson, Bryan C., Li, Xiang, Wei, Wei, Meunier, Frédéric A., Fernández-Moya, Sandra M., Kiebler, Michael A., Srinivasan, Balakumar, Banerjee, Sourav, Clark, Michael, Spitale, Robert C., and Bredy, Timothy W. (2023). Fear extinction is regulated by the activity of long noncoding RNAs at the synapse. Nature Communications 14 (1) 7616 1-16. https://doi.org/10.1038/s41467-023-43535-1

Synapse-enriched m6A-modified Malat1 interacts with the novel m6A reader, DPYSL2, and is required for fear-extinction memory

Madugalle, Sachithrani U., Liau, Wei-Siang, Zhao, Qiongyi, Li, Xiang, Gong, Hao, Marshall, Paul R., Periyakaruppiah, Ambika, Zajaczkowski, Esmi L., Leighton, Laura J., Ren, Haobin, Musgrove, Mason R. B., Davies, Joshua W. A., Kim, Gwangmin, Rauch, Simone, He, Chuan, Dickinson, Bryan C., Fulopova, Barbora, Fletcher, Lee N., Williams, Stephen R., Spitale, Robert C., and Bredy, Timothy W. (2023). Synapse-enriched m6A-modified Malat1 interacts with the novel m6A reader, DPYSL2, and is required for fear-extinction memory. The Journal of Neuroscience 43 (43) 7084-7100. https://doi.org/10.1523/jneurosci.0943-23.2023

Localised Cdr1as activity is required for fear extinction memory

Lau Zajaczkowski, Esmi, Zhao, Qiongyi, Liau, Wei-Siang, Gong, Hao, Madugalle, Sachithrani Umanda, Periyakaruppiah, Ambika, Leighton, Laura Jane, Musgrove, Mason, Ren, Haobin, Davies, Joshua, Marshall, Paul Robert, and Bredy, Timothy William (2023). Localised Cdr1as activity is required for fear extinction memory. Neurobiology of Learning and Memory 203 107777 107777. https://doi.org/10.1016/j.nlm.2023.107777

ADRAM is an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3

Wei, Wei, Zhao, Qiongyi, Wang, Ziqi, Liau, Wei-Siang, Basic, Dean, Ren, Haobin, Marshall, Paul R., Zajaczkowski, Esmi L., Leighton, Laura J., Madugalle, Sachithrani U., Musgrove, Mason, Periyakaruppiah, Ambika, Shi, Jichun, Zhang, Jianjian, Mattick, John S., Mercer, Timothy R., Spitale, Robert C., Li, Xiang, and Bredy, Timothy W. (2022). ADRAM is an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3. Cell Reports 38 (12) 110546 110546. https://doi.org/10.1016/j.celrep.2022.110546

From circuits to chromatin: the emerging role of epigenetics in mental health

Mews, Philipp, Calipari, Erin S., Day, Jeremy, Lobo, Mary Kay, Bredy, Timothy, and Abel, Ted (2021). From circuits to chromatin: the emerging role of epigenetics in mental health. The Journal of Neuroscience 41 (5) 873-882. https://doi.org/10.1523/jneurosci.1649-20.2020

On the functional relevance of spatiotemporally-specific patterns of experience-dependent long noncoding RNA expression in the brain

Liau, Wei-Siang, Samaddar, Sarbani, Banerjee, Sourav, and Bredy, Timothy W. (2021). On the functional relevance of spatiotemporally-specific patterns of experience-dependent long noncoding RNA expression in the brain. RNA Biology 18 (7) 1-12. https://doi.org/10.1080/15476286.2020.1868165

RNA N6-methyladenosine and the regulation of RNA localization and function in the brain

Madugalle, Sachithrani U., Meyer, Kate, Wang, Dan Ohtan, and Bredy, Timothy W. (2020). RNA N6-methyladenosine and the regulation of RNA localization and function in the brain. Trends in Neurosciences 43 (12) 1011-1023. https://doi.org/10.1016/j.tins.2020.09.005

Circular RNAs in the brain: a possible role in memory?

Zajaczkowski, Esmi L. and Bredy, Timothy W. (2020). Circular RNAs in the brain: a possible role in memory?. The Neuroscientist 27 (5) 1073858420963028-486. https://doi.org/10.1177/1073858420963028

Genome-wide microRNA profiling in brain and blood samples in a mouse model of epileptogenesis

Chen, Min, Zhao, Qiong-Yi, Edson, Janette, Zhang, Zong Hong, Li, Xiang, Wei, Wei, Bredy, Timothy, and Reutens, David C. (2020). Genome-wide microRNA profiling in brain and blood samples in a mouse model of epileptogenesis. Epilepsy Research 166 106400 1-7. https://doi.org/10.1016/j.eplepsyres.2020.106400