Dr Roger Bitencourt Varela
Casual Facility Officer & Postdoctoral Research Fellow
Queensland Brain Institute
Book Chapters
Varela, Roger B., Dal-Pont, Gustavo C., Quevedo, João and Valvassori, Samira S. (2022). Behavioral models of bipolar disorder. Biomarkers in Bipolar Disorders. (pp. 63-80) London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-821398-8.00015-1
Valvassori, Samira S., Varela, Roger B. and Quevedo, João (2017). Animal models of mood disorders: focus on bipolar disorder and depression. Animal models for the study of human disease. (pp. 991-1001) edited by P. Michael Conn. Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-809468-6.00038-3
Journal Articles
Macpherson, Heather K., Varela, Roger B., Truong, Trang T. T., Walder, Ken, Berk, Michael and Tye, Susannah J. (2026). Melatonin in bipolar disorder. Journal of Affective Disorders, 398 120871, 1-24. doi: 10.1016/j.jad.2025.120871
Cullen, Kathryn R., Tye, Susannah J., Klimes-Dougan, Bonnie, Wiesner, Hannes M., Varela, Roger B., Morath, Brooke, Zhang, Lin, Chen, Wei and Zhu, Xiao-Hong (2026). ATP bioenergetics and fatigue in young adults with and without major depression. Translational Psychiatry, 16 (1) 158. doi: 10.1038/s41398-026-03904-y
Varela, Roger B., Macpherson, Heather, Walker, Adam J., Houghton, Tristan, Yates, Clarissa, Yates, Nathanael J., Daygon, Dara and Tye, Susannah J. (2025). Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male rats. Brain, Behavior, and Immunity, 127, 170-182. doi: 10.1016/j.bbi.2025.03.001
Possamai-Della, Taise, Peper-Nascimento, Jefté, Varela, Roger B., Daminelli, Thiani, Fries, Gabriel R., Ceretta, Luciane B., Juruena, Mario F., Quevedo, João and Valvassori, Samira S. (2025). Exploring the impact of childhood maltreatment on epigenetic and brain-derived neurotrophic factor changes in bipolar disorder and healthy control. European Archives of Psychiatry and Clinical Neuroscience, 275 (7), 1969-1981. doi: 10.1007/s00406-024-01917-6
Varela, Roger B., Boschen, Suelen L., Yates, Nathanael, Houghton, Tristan, Blaha, Charles D., Lee, Kendall H., Bennet, Kevin E., Kouzani, Abbas Z., Berk, Michael, Quevedo, João, Valvassori, Samira S. and Tye, Susannah J. (2024). Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine. Bipolar Disorders, 26 (4), 376-387. doi: 10.1111/bdi.13423
Srivastav, Sunil, Cui, Xiaoying, Varela, Roger Bitencourt, Kesby, James P. and Eyles, Darryl (2023). Increasing dopamine synthesis in nigrostriatal circuits increases phasic dopamine release and alters dorsal striatal connectivity: implications for schizophrenia. Schizophrenia, 9 (1) 69, 69. doi: 10.1038/s41537-023-00397-2
Valvassori, Samira S., da Rosa, Richard T., Dal-Pont, Gustavo C., Varela, Roger B., Mastella, Gustavo A., Daminelli, Thiani, Fries, Gabriel R., Quevedo, Joao and Zugno, Alexandra I. (2023). Haloperidol alters neurotrophic factors and epigenetic parameters in an animal model of schizophrenia induced by ketamine. International Journal of Developmental Neuroscience, 83 (8), 691-702. doi: 10.1002/jdn.10296
Valvassori, Samira Silva, Varela, Roger Bitencourt, Resende, Wilson Rodrigues, Della, Taise Possamai, Borba, Laura Araújo, Behenck, João Paulo, Réus, Gislaine Zilli and Quevedo, João (2023). Antidepressant effect of sodium butyrate is accompanied by brain epigenetic modulation in rats subjected to early or late life stress. Current Neurovascular Research, 20 (5), 586-598. doi: 10.2174/0115672026277345240115101852
Corneo, Emily, Michels, Monique, Abatti, Mariane, Vieira, Andriele, Goncalves, Renata Casagrande, Gabriel, Filipe Fernandes, Borges, Heloisa, Goulart, Amanda, Matos, Natan da Silva, Dominguini, Diogo, Varela, Roger, Valvassori, Samira and Dal-Pizzol, Felipe (2022). Enriched environment causes epigenetic changes in hippocampus and improves long-term cognitive function in sepsis. Scientific Reports, 12 (1) 21092. doi: 10.1038/s41598-022-14660-6
Varela, Roger B., Cararo, José Henrique, Tye, Susannah J., Carvalho, Andre F., Valvassori, Samira S., Fries, Gabriel R. and Quevedo, João (2022). Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications. Neuroscience and Biobehavioral Reviews, 135 104579, 104579. doi: 10.1016/j.neubiorev.2022.104579
Canever, Lara, Varela, Roger, Mastella, Gustavo A., Damazio, Louyse S., Valvassori, Samira S., Quevedo, Joao L. and Zugno, Alexandra (2021). Effects of maternal folic acid supplementation on nuclear methyltransferase activity of adult rats subjected to an animal model of schizophrenia. International Journal of Developmental Neuroscience, 81 (5), 461-467. doi: 10.1002/jdn.10109
Valvassori, Samira S., Dal-Pont, Gustavo C., Varela, Roger B., Resende, Wilson R., Gava, Fernanda F., Mina, Franciele G., Budni, Josiane and Quevedo, João (2021). Ouabain induces memory impairment and alter the BDNF signaling pathway in an animal model of bipolar disorder: Cognitive and neurochemical alterations in BD model. Journal of Affective Disorders, 282, 1195-1202. doi: 10.1016/j.jad.2020.12.190
Varela, Roger B., Resende, Wilson R., Dal-Pont, Gustavo C., Gava, Fernanda F., Nadas, Gabriella B., Tye, Susannah J., Andersen, Monica L., Quevedo, João and Valvassori, Samira S (2020). Role of epigenetic regulatory enzymes in animal models of mania induced by amphetamine and paradoxical sleep deprivation. European Journal of Neuroscience, 53 (2) ejn.14922, 649-662. doi: 10.1111/ejn.14922
Bavaresco, Daniela, da Rosa, Maria Ines, Rodrigues Uggioni, Maria Laura, Ferraz, Sarah D., Pacheco, Tamires R., Zuehl Dal Toe, Helena C., da Silveira, Andressa P., Quadros, Luiz F. A., de Souza, Thiani Daminelli, Varela, Roger B., Vieira, Andriele A. S., Dal Pizzol, Felipe, Valvassori, Samira S. and Quevedo, Joao (2020). Increased inflammatory biomarkers and changes in biological rhythms in bipolar disorder: a case-control study. Journal of Affective Disorders, 271, 115-122. doi: 10.1016/j.jad.2020.03.073
Varela, Roger B., Resende, Wilson R., Dal-Pont, Gustavo C., Gava, Fernanda F., Tye, Susannah J., Quevedo, João and Valvassori, Samira S. (2020). HDAC inhibitors reverse mania-like behavior and modulate epigenetic regulatory enzymes in an animal model of mania induced by Ouabain. Pharmacology Biochemistry and Behavior, 193 172917, 172917. doi: 10.1016/j.pbb.2020.172917
Menegas, Samira, Dal-Pont, Gustavo C., Cararo, José H., Varela, Roger B., Aguiar-Geraldo, Jorge M., Possamai-Della, Taise, Andersen, Monica L., Quevedo, João and Valvassori, Samira S. (2019). Efficacy of folic acid as an adjunct to lithium therapy on manic-like behaviors, oxidative stress and inflammatory parameters in an animal model of mania. Metabolic Brain Disease, 35 (2), 413-425. doi: 10.1007/s11011-019-00503-3
Valvassori, Samira S., Tonin, Paula T., Dal-Pont, Gustavo C., Varela, Roger B., Cararo, José Henrique, Garcia, Abel Freitas, Gava, Fernanda F., Menegas, Samira, Soares, Jair C. and Quevedo, João (2019). Coadministration of lithium and celecoxib reverses manic-like behavior and decreases oxidative stress in a dopaminergic model of mania induced in rats. Translational Psychiatry, 9 (1) 297, 1-11. doi: 10.1038/s41398-019-0637-9
Valvassori, Samira S., Dal-Pont, Gustavo C., Tonin, Paula T., Varela, Roger B., Ferreira, Camila L., Gava, Fernanda F., Andersen, Monica L., Soares, Jair C. and Quevedo, Joao (2019). Coadministration of lithium and celecoxib attenuates the behavioral alterations and inflammatory processes induced by amphetamine in an animal model of mania. Pharmacology, Biochemistry and Behavior, 183, 56-63. doi: 10.1016/j.pbb.2019.05.009
Valvassori, Samira S., Dal-Pont, Gustavo C., Resende, Wilson R., Varela, Roger B., Lopes-Borges, Jessica, Cararo, Jose Henrique and Quevedo, Joao (2019). Validation of the animal model of bipolar disorder induced by Ouabain: face, construct and predictive perspectives. Translational Psychiatry, 9 (1) 158. doi: 10.1038/s41398-019-0494-6
Dal-Pont, Gustavo C., Resende, Wilson R., Bianchini, Guilherme, Gava, Fernanda F., Peterle, Bruna R., Trajano, Kerolen S., Varela, Roger B., Quevedo, Joao and Valvassori, Samira S. (2019). Tamoxifen has an anti-manic effect but not protect the brain against oxidative stress in an animal model of mania induced by ouabain. Journal of Psychiatric Research, 113, 181-189. doi: 10.1016/j.jpsychires.2019.03.020
Dal-Pont, Gustavo C., Resende, Wilson R., Varela, Roger B., Menegas, Samira, Trajano, Kerolen S., Peterle, Bruna R., Quevedo, Joao and Valvassori, Samira S. (2019). Inhibition of GSK-3β on behavioral changes and oxidative stress in an animal model of mania. Molecular Neurobiology, 56 (4), 2379-2393. doi: 10.1007/s12035-018-1226-2
Valvassori, Samira S., Mariot, Edemilson, Varela, Roger B., Bavaresco, Daniela V., Dal-Pont, Gustavo C., Ferreira, Camila L., Andersen, Monica L., Tye, Susannah J. and Quevedo, João (2019). The role of neurotrophic factors in manic-, anxious- and depressive-like behaviors induced by amphetamine sensitization: implications to the animal model of bipolar disorder. Journal of Affective Disorders, 245, 1106-1113. doi: 10.1016/j.jad.2018.10.370
Garcez, Michelle Lima, de Carvalho, Carlos Alberto, Mina, Francielle, Bellettini-Santos, Tatiani, Schiavo, Gustavo Luis, da Silva, Sabrina, Campos, Ana Carolina Brunatto Falchetti, Varela, Roger Bitencourt, Valvassori, Samira S., Damiani, Adriani Paganini, Longaretti, Luiza Martins, de Andrade, Vanessa Moraes and Budni, Josiane (2018). Sodium butyrate improves memory and modulates the activity of histone deacetylases in aged rats after the administration of D-galactose. Experimental Gerontology, 113, 209-217. doi: 10.1016/j.exger.2018.10.005
Valvassori, Samira S., Borges, Cenita, Bavaresco, Daniela V., Varela, Roger B., Resende, Wilson R., Peterle, Bruna R., Arent, Camila O., Budni, Josiane and Quevedo, João (2018). Hypericum perforatum chronic treatment affects cognitive parameters and brain neurotrophic factor levels. Revista Brasileira de Psiquiatria, 40 (4), 367-375. doi: 10.1590/1516-4446-2017-2271
Valvassori, Samira S., Bavaresco, Daniela V., Feier, Gustavo, Cechinel-Recco, Kelen, Steckert, Amanda V., Varela, Roger B., Borges, Cenita, Carvalho-Silva, Milena, Gomes, Lara M., Streck, Emílio L. and Quevedo, João (2018). Increased oxidative stress in the mitochondria isolated from lymphocytes of bipolar disorder patients during depressive episodes. Psychiatry Research, 264, 192-201. doi: 10.1016/j.psychres.2018.03.089
Valvassori, Samira S., Resende, Wilson R., Varela, Roger B., Arent, Camila O., Gava, Fernanda F., Peterle, Bruna R., Dal-Pont, Gustavo C., Carvalho, André F., Andersen, Monica L. and Quevedo, João (2018). The Effects of Histone Deacetylase Inhibition on the Levels of Cerebral Cytokines in an Animal Model of Mania Induced by Dextroamphetamine. Molecular Neurobiology, 55 (2), 1430-1439. doi: 10.1007/s12035-017-0384-y
Valvassori, Samira S., Dal-Pont, Gustavo C., Resende, Wilson R., Varela, Roger B., Peterle, Bruna R., Gava, Fernanda F., Mina, Francielle G., Cararo, José H., Carvalho, André F. and Quevedo, João (2017). Lithium and tamoxifen modulate behavior and Protein Kinase C activity in the animal model of mania induced by ouabain. International Journal of Neuropsychopharmacology, 20 (11), 877-885. doi: 10.1093/ijnp/pyx049
Valvassori, Samira S., Borges, Cenita P., Varela, Roger B., Bavaresco, Daniela V., Bianchini, Guilherme, Mariot, Edemilson, Arent, Camila O., Resende, Wilson R., Budni, Josiane and Quevedo, João (2017). The different effects of lithium and tamoxifen on memory formation and the levels of neurotrophic factors in the brain of male and female rats. Brain Research Bulletin, 134, 228-235. doi: 10.1016/j.brainresbull.2017.08.006
Valvassori, Samira S., Resende, Wilson R., Dal-Pont, Gustavo, Sangaletti-Pereira, Heron, Gava, Fernanda F., Peterle, Bruna R., Carvalho, André F., Varela, Roger B., Dal-Pizzol, Felipe and Quevedo, João (2017). Lithium ameliorates sleep deprivation-induced mania-like behavior, hypothalamic-pituitary-adrenal (HPA) axis alterations, oxidative stress and elevations of cytokine concentrations in the brain and serum of mice. Bipolar Disorders, 19 (4), 246-258. doi: 10.1111/bdi.12503
Fries, Gabriel R., Valvassori, Samira S., Bock, Hugo, Stertz, Laura, Magalhães, Pedro Vieira da Silva, Mariot, Edimilson, Varela, Roger B., Kauer-Sant'Anna, Marcia, Quevedo, João, Kapczinski, Flávio and Saraiva-Pereira, Maria Luiza (2015). Memory and brain-derived neurotrophic factor after subchronic or chronic amphetamine treatment in an animal model of mania. Journal of Psychiatric Research, 68, 329-336. doi: 10.1016/j.jpsychires.2015.05.006
Valvassori, Samira S., Arent, Camila O., Steckert, Amanda V., Varela, Roger B., Jornada, Luciano K., Tonin, Paula T., Budni, Josiane, Mariot, Edemilson, Kapczinski, Flávio and Quevedo, João (2015). Intracerebral Administration of BDNF Protects Rat Brain Against Oxidative Stress Induced by Ouabain in an Animal Model of Mania. Molecular Neurobiology, 52 (1), 353-362. doi: 10.1007/s12035-014-8873-8
Valvassori, Samira S., Tonin, Paula T., Varela, Roger B., Carvalho, André F., Mariot, Edemilson, Amboni, Rafaela T., Bianchini, Guilherme, Andersen, Monica L. and Quevedo, João (2015). Lithium modulates the production of peripheral and cerebral cytokines in an animal model of mania induced by dextroamphetamine. Bipolar Disorders, 17 (5), 507-517. doi: 10.1111/bdi.12299
Leffa, Daniela D., Valvassori, Samira S., Varela, Roger B., Lopes-Borges, Jésica, Daumann, Francine, Longaretti, Luiza M., Dajori, Ana Luiza F., Quevedo, João and Andrade, Vanessa M. (2015). Effects of palatable cafeteria diet on cognitive and noncognitive behaviors and brain neurotrophins’ levels in mice. Metabolic Brain Disease, 30 (4), 1073-1082. doi: 10.1007/s11011-015-9682-0
Valvassori, Samira S., Dal-Pont, Gustavo C., Steckert, Amanda V., Varela, Roger B., Lopes-Borges, Jéssica, Mariot, Edemilson, Resende, Wilson R., Arent, Camila O., Carvalho, André F. and Quevedo, João (2015). Sodium butyrate has an antimanic effect and protects the brain against oxidative stress in an animal model of mania induced by ouabain. Psychiatry Research, 235, 154-159. doi: 10.1016/j.psychres.2015.11.017
Gonçalves, Cinara L., Furlanetto, Camila B., Valvassori, Samira S., Bavaresco, Daniela V., Varela, Roger B., Budni, Josiane, Quevedo, João and Streck, Emilio L. (2015). Effects of chronic administration of fenproporex on cognitive and non-cognitive behaviors. Metabolic Brain Disease, 30 (2), 583-588. doi: 10.1007/s11011-014-9617-1
Varela, Roger B., Valvassori, Samira S., Lopes-Borges, Jéssica, Mariot, Edemilson, Dal-Pont, Gustavo C., Amboni, Rafaela T., Bianchini, Guilherme and Quevedo, João (2015). Sodium butyrate and mood stabilizers block ouabain-induced hyperlocomotion and increase BDNF, NGF and GDNF levels in brain of Wistar rats. Journal of Psychiatric Research, 61, 114-121. doi: 10.1016/j.jpsychires.2014.11.003
Lopes-Borges, Jéssica, Valvassori, Samira S., Varela, Roger B., Tonin, Paula T., Vieira, Julia S., Gonçalves, Cinara L., Streck, Emilio L. and Quevedo, João (2014). Histone deacetylase inhibitors reverse manic-like behaviors and protect the rat brain from energetic metabolic alterations induced by ouabain. Pharmacology Biochemistry and Behavior, 128, 89-95. doi: 10.1016/j.pbb.2014.11.014
Tonin, Paula T., Valvassori, Samira S., Lopes-Borges, Jéssica, Mariot, Edemilson, Varela, Roger B., Teixeira, AntÔnio Lucio and Quevedo, João (2014). Effects of ouabain on cytokine/chemokine levels in an animal model of mania. Journal of Neuroimmunology, 276 (1-2), 236-239. doi: 10.1016/j.jneuroim.2014.09.007
Rezin, Gislaine T., Scaini, Giselli, Gonçalves, Cinara L., Ferreira, Gabriela K., Cardoso, Mariane R., Ferreira, Andréa G.K., Cunha, Maira J., Schmitz, Felipe, Varela, Roger B., Quevedo, João, Wyse, Angela T.S. and Streck, Emilio Luiz (2014). Evaluation of Na+, K+-ATPase activity in the brain of young rats after acute administration of fenproporex. Revista Brasileira de Psiquiatria, 36 (2), 138-142. doi: 10.1590/1516-4446-2012-0956
Rezin, Gislaine T., Furlanetto, Camila B., Scaini, Giselli, Valvassori, Samira S., Gonçalves, Cinara L., Ferreira, Gabriela K., Jeremias, Isabela C., Resende, Wilson R., Cardoso, Mariane R., Varela, Roger B., Quevedo, João and Streck, Emilio L. (2014). Fenproporex increases locomotor activity and alters energy metabolism, and mood stabilizers reverse these changes: A proposal for a new animal model of mania. Molecular Neurobiology, 49 (2), 877-892. doi: 10.1007/s12035-013-8566-8
Ornell, Felipe, Valvassori, Samira S., Steckert, Amanda V., Deroza, Pedro F., Resende, Wilson R., Varela, Roger B. and Quevedo, João (2014). Modafinil effects on behavior and oxidative damage parameters in brain of wistar rats. Behavioural Neurology, 2014 917246, 1-7. doi: 10.1155/2014/917246
Valvassori, Samira Silva, Varela, Roger Bitencourt, Arent, Camila Orlandi, Dal-Pont, Gustavo Colombo, Bobsin, Tamara Sarate, Budni, Josiane, Réus, Gislaine Zilli and Quevedo, João (2014). Sodium butyrate functions as an antidepressant and improves cognition with enhanced neurotrophic expression in models of maternal deprivation and chronic mild stress. Current Neurovascular Research, 11 (4), 359-366. doi: 10.2174/1567202611666140829162158
Model, Camila S., Gomes, Lara M., Scaini, Giselli, Ferreira, Gabriela K., Gonçalves, Cinara L., Rezin, Gislaine T., Steckert, Amanda V., Valvassori, Samira S., Varela, Roger B., Quevedo, João and Streck, Emilio L. (2014). Omega-3 fatty acids alter behavioral and oxidative stress parameters in animals subjected to fenproporex administration. Metabolic Brain Disease, 29 (1), 185-192. doi: 10.1007/s11011-013-9473-4
Valvassori, Samira S., Calixto, Karen V., Budni, Josiane, Resende, Wilson R., Varela, Roger B., De Freitas, Karolina V., Gonçalves, Cinara L., Streck, Emilio L. and Quevedo, João (2013). Sodium butyrate reverses the inhibition of Krebs cycle enzymes induced by amphetamine in the rat brain. Journal of Neural Transmission, 120 (12), 1737-1742. doi: 10.1007/s00702-013-1056-3
Valvassori, Samira S., Budni, Josiane, Varela, Roger B. and Quevedo, João (2013). Contributions of animal models to the study of mood disorders. Revista Brasileira de Psiquiatria, 35 (SUPPL.2), S121-S131. doi: 10.1590/1516-4446-2013-1168
Resende, Wilson R., Valvassori, Samira S., Réus, Gislaine Z., Varela, Roger B., Arent, Camila O., Ribeiro, Karine F., Bavaresco, Daniela V., Andersen, Monica L., Zugno, Alexandra I. and Quevedoa, Joaõ (2013). Effects of sodium butyrate in animal models of mania and depression: Implications as a new mood stabilizer. Behavioural Pharmacology, 24 (7), 569-579. doi: 10.1097/FBP.0b013e32836546fc
Varela, Roger B., Valvassori, Samira S., Lopes-Borges, Jéssica, Fraga, Daiane B., Resende, Wilson R., Arent, Camila O., Zugno, Alexandra I. and Quevedo, João (2013). Evaluation of acetylcholinesterase in an animal model of mania induced by d-amphetamine. Psychiatry Research, 209 (2), 229-234. doi: 10.1016/j.psychres.2012.11.021
Steckert, Amanda V., Valvassori, Samira S., Varela, Roger B., Mina, Francielle, Resende, Wilson R., Bavaresco, Daniela V., Ornell, Felipe, Dal-Pizzol, Felipe and Quevedo, João (2013). Effects of sodium butyrate on oxidative stress and behavioral changes induced by administration of d-AMPH. Neurochemistry International, 62 (4), 425-432. doi: 10.1016/j.neuint.2013.02.001
Valvassori, Samira S., Bavaresco, Daniela V., Scaini, Giselli, Varela, Roger B., Streck, Emilio L., Chagas, Marcos H., Hallak, Jaime E. C., Zuardi, Antonio W., Crippa, José A. and Quevedo, João (2013). Acute and chronic administration of cannabidiol increases mitochondrial complex and creatine kinase activity in the rat brain. Revista Brasileira de Psiquiatria, 35 (4), 380-386. doi: 10.1590/1516-4446-2012-0886
Feier, Gustavo, Valvassori, Samira S., Varela, Roger B., Resende, Wilson R., Bavaresco, Daniela V., Morais, Meline O., Scaini, Giselli, Andersen, Monica L., Streck, Emilio L. and Quevedo, João (2013). Lithium and valproate modulate energy metabolism in an animal model of mania induced by methamphetamine. Pharmacology Biochemistry and Behavior, 103 (3), 589-596. doi: 10.1016/j.pbb.2012.09.010
Cechinel-Recco, Kelen, Valvassori, Samira S, Varela, Roger B, Resende, Wilson R, Arent, Camila O., Vitto, Marcelo F., Luz, Gabrielle, De Souza, Claudio T. and Quevedo, João (2012). Lithium and tamoxifen modulate cellular plasticity cascades in animal model of mania. Journal of Psychopharmacology, 26 (12), 1594-1604. doi: 10.1177/0269881112463124
Feier, Gustavo, Valvassori, Samira S., Lopes-Borges, Jéssica, Varela, Roger B., Bavaresco, Daniela V., Scaini, Giselli, Morais, Meline O., Andersen, Monica L., Streck, Emilio L. and Quevedo, João (2012). Behavioral changes and brain energy metabolism dysfunction in rats treated with methamphetamine or dextroamphetamine. Neuroscience Letters, 530 (1), 75-79. doi: 10.1016/j.neulet.2012.09.039
da-Rosa, Dayane D., Valvassori, Samira S., Steckert, Amanda V., Ornell, Felipe, Ferreira, Camila L., Lopes-Borges, Jéssica, Varela, Roger B., Dal-Pizzol, Felipe, Andersen, Monica L. and Quevedo, João (2012). Effects of lithium and valproate on oxidative stress and behavioral changes induced by administration of m-AMPH. Psychiatry Research, 198 (3), 521-526. doi: 10.1016/j.psychres.2012.01.019
Steckert, Amanda Valnier, Valvassori, Samira Silva, Mina, Francielle, Lopes-Borges, Jéssica, Varela, Roger Bitencourt, Kapczinski, Flávio, Dal-Pizzol, Felipe and Quevedo, João (2012). Protein kinase C and oxidative stress in an animal model of mania. Current Neurovascular Research, 9 (1), 47-57. doi: 10.2174/156720212799297056
Da-Rosa, Dayane D., Valvassori, Samira S., Steckert, Amanda V., Arent, Camila O., Ferreira, Camila L., Lopes-Borges, Jéssica, Varela, Roger B., Mariot, Edemilson, Dal-Pizzol, Felipe, Andersen, Monica L. and Quevedo, João (2012). Differences between dextroamphetamine and methamphetamine: Behavioral changes and oxidative damage in brain of Wistar rats. Journal of Neural Transmission, 119 (1), 31-38. doi: 10.1007/s00702-011-0691-9
Moretti, Morgana, Valvassori, Samira S., Varela, Roger B., Ferreira, Camila L., Rochi, Natalia, Benedet, Joana, Scaini, Giselli, Kapczinski, Flávio, Streck, Emilio L., Zugno, Alexandra I. and Quevedo, João (2011). Behavioral and neurochemical effects of sodium butyrate in an animal model of mania. Behavioural Pharmacology, 22 (8), 766-772. doi: 10.1097/FBP.0b013e32834d0f1b
Arent, Camila O., Valvassori, Samira S., Fries, Gabriel R., Stertz, Laura, Ferreira, Camila L., Lopes-Borges, Jéssica, Mariot, Edemilson, Varela, Roger B., Ornell, Felipe, Kapczinski, Flávio, Andersen, Monica L. and Quevedo, João (2011). Neuroanatomical profile of antimaniac effects of histone deacetylases inhibitors. Molecular Neurobiology, 43 (3), 207-214. doi: 10.1007/s12035-011-8178-0
Conference Papers
Varela, Roger, Macpherson, Heather, Houghton, Tristan, Yates, Clarissa, Yates, Nathanael, Daygon, Dara and Tye, Susannah (2025). Immunometabolic dysfunction and dopaminergic impairment in an animal model of treatment-resistant anhedonia: implications for bipolar disorder. The 27th Annual Conference of the International Society for Bipolar Disorders, Chiba, Japan, 17 – 19 September 2025. Hoboken, NJ, United States: Wiley-Blackwell Publishing.
Varela, Roger, Cullen, Kathryn, Morath, Brooke and Tye, Susannah (2025). Bioenergetic Dysregulation in Peripheral Immune Cells: Links to Anhedonia and Fatigue in Depressed Young Adults. The 27th Annual Conference of the International Society for Bipolar Disorders, Chiba, Japan, 17 – 19 September 2025. Hoboken, NJ, United States: Wiley-Blackwell Publishing.
Macpherson, Heather, Varela, Roger, McCullough, Sebastian, Houghton, Tristan, Chawla, Isha, Wang, Ning, Daygon, Venea, Cui, Xiaoying and Tye, Susannah (2025). Unpredictable Circadian Disturbance Induces Bipolar-Like Behavioural and Immunometabolic Dysregulation in Rats. 27th Annual Conference of the International Society for Bipolar Disorders, Chiba, Japan, 17-19 September 2025. Hoboken, NJ, United States: Wiley-Blackwell.
Macpherson, Heather, Varela, Roger, Daygon, Venea, Kesby, James, Cui, Xiaoying and Tye, Susannah (2025). Melatonin Mitigates IL-6-Induced Hyperdopaminergia, Oxidative Stress, and Metabolic Dysfunction: Implications for Dopaminergic Dysregulation in Bipolar Disorder. The 27th Annual Conference of the International Society for Bipolar Disorders, Chiba, Japan, 17 – 19 September 2025. Hoboken, NJ, United States: Wiley-Blackwell Publishing.
Della, T. de Souza Possamai, Peper-Nascimento, J., Varela, R.B., Daminelli, T., Fries, G.R., Ceretta, L.B., Quevedo, J. and Valvassori, S.S. (2024). Exploring the relationship between childhood trauma and epigenetic alterations in bipolar disorder. 37th ECNP Congress 2024, Milan, Italy, 21-24 September 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.nsa.2024.104182