Publications
Journal Articles
Martínez-Mármol, Ramón, Mohannak, Nika, Qian, Lei, Wang, Tong, Gormal, Rachel S, Ruitenberg, Marc J, Vanhaesebroeck, Bart, Coulson, Elizabeth J and Meunier, Frédéric A (2019) p110δ PI 3-kinase inhibition perturbs APP and TNFα trafficking, reduces plaque burden, dampens neuroinflammation and prevents cognitive decline in an Alzheimer's disease mouse model. Journal of Neuroscience, 39 40: 7976-7991. doi:10.1523/JNEUROSCI.0674-19.2019
Bademosi, Adekunle T. , Steeves, James, Karunanithi, Shanker, Zalucki, Oressia H, Gormal, Rachel S, Liu, Shu, Lauwers, Elsa, Verstreken, Patrik, Anggono, Victor, Meunier, Frederic A and van Swinderen, Bruno (2018) Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic. Cell reports, 22 2: 427-440. doi:10.1016/j.celrep.2017.12.054
Tomatis, Vanesa M., Josh, Peter, Papadopulos, Andreas, Gormal, Rachel S., Lanoue, Vanessa, Martin, Sally and Meunier, Frédéric A. (2017) ENA/VASP proteins regulate exocytosis by mediating myosin VI-dependent recruitment of secretory granules to the cortical actin network. Molecular and Cellular Neuroscience, 84 100-111. doi:10.1016/j.mcn.2017.07.005
Gormal, R. S., Valmas, N., Fath, T. and Meunier, F. A. (2017) A role for tropomyosins in activity-dependent bulk endocytosis?. Molecular and Cellular Neuroscience, 84 112-118. doi:10.1016/j.mcn.2017.04.003
Wang, Tong, Martin, Sally, Nguyen, Tam H., Harper, Callista B., Gormal, Rachel S., Martinez-Marmol, Ramon, Karunanithi, Shanker, Coulson, Elizabeth J., Glass, Nick R., Cooper-White, Justin J., Van Swinderen, Bruno and Meunier, Frederic A. (2016) Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB. Nature Communications, 7 12976. doi:10.1038/ncomms12976
Kasula, Ravikiran, Chai, Ye Jin, Bademosi, Adekunle T., Harper, Callista B., Gormal, Rachel S., Morrow, Isabel C., Hosy, Eric, Collins, Brett M., Choquet, Daniel, Papadopulos, Andreas and Meunier, Frederic A. (2016) The Munc18-1 domain 3a hinge-loop controls syntaxin-1A nanodomain assembly and engagement with the SNARE complex during secretory vesicle priming. The Journal of Cell Biology, 214 7: 847-858. doi:10.1083/jcb.201508118
Chai, Ye Jin, Sierecki, Emma, Tomatis, Vanesa M., Gormal, Rachel S., Giles, Nichole, Morrow, Isabel C., Xia, Di, Götz, Jürgen, Parton, Robert G., Collins, Brett M., Gambin, Yann and Meunier, Frédéric A. (2016) Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation. The Journal of Cell Biology, 214 6: 705-718. doi:10.1083/jcb.201512016
Papadopulos, Andreas, Gomez, Guillermo A., Martin, Sally, Jackson, Jade, Gormal, Rachel S., Keating, Damien J., Yap, Alpha S. and Meunier, Frederic A. (2015) Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking. Nature Communications, 6 6297: 1-11. doi:10.1038/ncomms7297
Gormal, Rachel S, Nguyen, Tam H, Martin, Sally, Papadopulos, Andreas and Meunier, Frederic A (2015) An acto-myosin II constricting ring initiates the fission of activity-dependent bulk endosomes in neurosecretory cells. Journal of Neuroscience, 35 4: 1380-1389. doi:10.1523/JNEUROSCI.3228-14.2015
Martin, Sally, Papadopulos, Andreas, Tomatis, Vanesa M., Sierecki, Emma, Malintan, Nancy T., Gormal, Rachel S., Giles, Nichole, Johnston, Wayne A., Alexandrov, Kirill, Gambin, Yann, Collins, Brett M. and Meunier, Frederic A. (2014) Increased polyubiquitination and proteasomal degradation of a Munc18-1 disease-linked mutant causes temperature-sensitive defect in exocytosis. Cell Reports, 9 1: 206-218. doi:10.1016/j.celrep.2014.08.059
Martin, Sally, Tomatis, Vanesa M., Papadopulos, Andreas, Christie, Michelle P., Malintan, Nancy T., Gormal, Rachel S., Sugita, Shuzo, Martin, Jennifer L., Collins, Brett M. and Meunier, Frederic A. (2013) The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane. Journal of Cell Science, 126 11: 2353-2360. doi:10.1242/jcs.126813
Tomatis, Vanesa M., Papadopulos, Andreas, Malintan, Nancy T., Martin, Sally, Wallis, Tristan, Gormal, Rachel S., Kendrick-Jones, John, Buss, Folma and Meunier, Frederic A. (2013) Myosin VI small insert isoform maintains exocytosis by tethering secretory granules to the cortical actin. Journal of Cell Biology, 200 3: 301-320. doi:10.1083/jcb.201204092
Papadopulos, Andreas, Martin, Sally, Tomatis, Vanesa M., Gormal, Rachel S. and Meunier, Frederic A. (2013) Secretagogue stimulation of neurosecretory cells elicits filopodial extensions uncovering new functional release sites. Journal of Neuroscience, 33 49: 19143-19153. doi:10.1523/JNEUROSCI.2634-13.2013