Book Chapters
Thomas, Walter (2009). Immunoprecipitation and Phosphorylation of G Protein-Coupled Receptors. G Protein-Coupled Receptors in Drug Discovery. (pp. 359-371) edited by Wayne R. Leifert. USA: Springer Science & Business Media, LLC. doi: 10.1007/978-1-60327-317-6_26
Bourne, A.M. and Thomas, W.G. (2007). ADAMs as mediators of AngII actions. Frontiers in Research of the Renin-Angiotensin System on Human Disease. (pp. 273-302) edited by Po Sing Leung. Dordrecht, The Netherlands: Springer, Heidelberg.
Bourne, A. M. and Thomas, W. G. (2007). ADAMs as mediators of Angiotensin II actions.. Frontiers in Research of the Renin-Angiotensin System on Human Disease. (pp. 273-301) edited by Nigel M. Hooper and Uwe Lendeckel. Netherlands: Springer. doi: 10.1007/978-1-4020-6372-5_13
Pattenden, Leonard K. and Thomas, Walter G. (2007). Amylose Affinity Chromatography of Maltose-Binding Protein: Purification by both Native and Novel Matrix-Assisted Dialysis-Refolding Methods. Affinity Chromatography: Methods and Protocols. (pp. 196-217) edited by Michael Zachariou. Totowa, NJ: Humana Press.
Journal Articles
Redd, Meredith A, Yoshikawa, Yusuke, Khan, Nemat, Waqar, Maleeha, Saez, Natalie J, Outhwaite, Jennifer E, Russell, Jake S, Hanna, Amy D, Chiu, Han S, Er, Sing Yan, Butcher, Neville J, Mardon, Karine, Fraser, John F, Smythe, Mark L, Rash, Lachlan D, Thomas, Walter G, King, Glenn F, Reichelt, Melissa E and Palpant, Nathan J (2024). Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction. European Heart Journal, 45 (17), 1571-1574. doi: 10.1093/eurheartj/ehad793
Bloxham, Conor J., Hulme, Katina D., Fierro, Fabrizio, Fercher, Christian, Pegg, Cassandra L., O'Brien, Shannon L., Foster, Simon R., Short, Kirsty R., Furness, Sebastian G. B., Reichelt, Melissa E., Niv, Masha Y. and Thomas, Walter G. (2024). Cardiac human bitter taste receptors contain naturally occurring variants that alter function. Biochemical Pharmacology, 219 115932, 115932. doi: 10.1016/j.bcp.2023.115932
Alexander, Wayne, Bernstein, Kenneth E., Catt, Kevin J., De Gasparo, Marc, Dhanachandra Singh, Khuraijam, Eguchi, Satoru, Escher, Emanuel, Goodfriend, Theodore L., Horiuchi, Mastgugu, Hunyady, László, Husain, Ahsan, Inagami, Tadashi, Karnik, Sadashiva, Kemp, Jacqueline, Thomas, Walter G., Timmermans, Pieter B. M. W. M., Tirupula, Kalyan, Unal, Hamiyet, Unger, Thomas and Vanderheyden, Patrick (2023). Angiotensin receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE, 2023 (1), 1-21. doi: 10.2218/gtopdb/f6/2023.1
Ashton, Kevin J., Kiessling, Can J., Thompson, Jamie-Lee M., Aziz, Aliah Y., Thomas, Walter G., Headrick, John P. and Reichelt, Melissa E. (2023). Early cardiac aging linked to impaired stress-resistance and transcriptional control of stress response, quality control and mitochondrial pathways. Experimental Gerontology, 171 112011, 1-15. doi: 10.1016/j.exger.2022.112011
Mohamed, Raafat, Shajimoon, Aravindra, Afroz, Rizwana, Gabr, Mai, Thomas, Wally, Little, Peter J. and Kamato, Danielle (2022). Akt acts as a switch for GPCR transactivation of the TGF‐β receptor type 1. The FEBS Journal, 289 (9), 2642-2656. doi: 10.1111/febs.16297
Eagles, David A., Saez, Natalie J., Krishnarjuna, Bankala, Bradford, Julia J., Chin, Yanni K.-Y., Starobova, Hana, Mueller, Alexander, Reichelt, Melissa E., Undheim, Eivind A. B., Norton, Raymond S., Thomas, Walter G., Vetter, Irina, King, Glenn F. and Robinson, Samuel D. (2022). A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals. Proceedings of the National Academy of Sciences, 119 (7) e2112630119. doi: 10.1073/pnas.2112630119
O'Brien, Shannon L., Johnstone, Elizabeth K.M., Devost, Dominic, Conroy, Jacinta, Reichelt, Melissa E., Purdue, Brooke W., Ayoub, Mohammed A., Kawai, Tatsuo, Inoue, Asuka, Eguchi, Satoru, Hébert, Terence E., Pfleger, Kevin D.G. and Thomas, Walter G. (2021). Corrigendum to “BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes” [Biochem. Pharmacol. 158 (2108) 232–242] (Biochemical Pharmacology (2018) 158 (232–242), (S0006295218304386), (10.1016/j.bcp.2018.10.017)). Biochemical Pharmacology, 192 114756, 114756. doi: 10.1016/j.bcp.2021.114756
Redd, Meredith A., Scheuer, Sarah E., Saez, Natalie J., Yoshikawa, Yusuke, Chiu, Han Sheng, Gao, Ling, Hicks, Mark, Villanueva, Jeanette E., Joshi, Yashutosh, Chow, Chun Yuen, Cuellar-Partida, Gabriel, Peart, Jason N., See Hoe, Louise E., Chen, Xiaoli, Sun, Yuliangzi, Suen, Jacky Y., Hatch, Robert J., Rollo, Ben, Xiao, Di, Alzubaidi, Mubarak A.H., Maljevic, Snezana, Quaife-Ryan, Gregory A., Hudson, James E., Porrello, Enzo R., White, Melanie Y., Cordwell, Stuart J., Fraser, John F., Petrou, Steven, Reichelt, Melissa E. ... Palpant, Nathan J. (2021). Therapeutic inhibition of acid sensing ion channel 1a recovers heart function after ischemia-reperfusion injury. Circulation, 144 (12), 947-960. doi: 10.1161/circulationaha.121.054360
Alexander, Stephen PH, Christopoulos, Arthur, Davenport, Anthony P, Kelly, Eamonn, Mathie, Alistair, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Davies, Jamie A, Abbracchio, Maria Pia, Alexander, Wayne, Al‐hosaini, Khaled, Bäck, Magnus, Barnes, Nicholas M., Bathgate, Ross, Beaulieu, Jean‐Martin, Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J.M., Blaho, Victoria, Boulay, Francois, Bousquet, Corinne, Bräuner‐Osborne, Hans, Burnstock, Geoffrey, Caló, Girolamo ... Ye, Richard D. (2021). The concise guide to pharmacology 2021/22: G protein‐coupled receptors. British Journal of Pharmacology, 178 (S1), S27-S156. doi: 10.1111/bph.15538
Sinclair, Jane E., Bloxham, Conor J., Chiu, Han, Chew, Keng Yih, Russell, Jake, Yoshikawa, Yusuke, Bielefeldt-Ohmann, Helle, Steele, Lauren E., Hulme, Katina D., Verzele, Nathalie A. J., Noye, Ellesandra C., Wu, Melanie, Reichelt, Melissa E., Thomas, Walter G., Gallo, Linda A., Redd, Meredith A. and Short, Kirsty R. (2021). Type I diabetes mellitus increases the cardiovascular complications of influenza virus infection. Frontiers in Cellular and Infection Microbiology, 11 714440, 714440. doi: 10.3389/fcimb.2021.714440
Wang, Zhen, Chan, Hsiu‐Wen, Gambarotta, Giovanna, Smith, Nicola J., Purdue, Brooke W., Pennisi, David J., Porrello, Enzo R., O'Brien, Shannon L., Reichelt, Melissa E., Thomas, Walter G. and Paravicini, Tamara M. (2021). Stimulation of the four isoforms of receptor tyrosine kinase ErbB4, but not ErbB1, confers cardiomyocyte hypertrophy. Journal of Cellular Physiology, 236 (12) jcp.30487, 8160-8170. doi: 10.1002/jcp.30487
Johnstone, Elizabeth K.M., Abhayawardana, Rekhati S., See, Heng B., Seeber, Ruth M., O'Brien, Shannon L., Thomas, Walter G. and Pfleger, Kevin D.G. (2021). Complex interactions between the angiotensin II type 1 receptor, the epidermal growth factor receptor and TRIO-dependent signaling partners. Biochemical Pharmacology, 188 114521, 1-16. doi: 10.1016/j.bcp.2021.114521
Gormal, Rachel S., Padmanabhan, Pranesh, Kasula, Ravikiran, Bademosi, Adekunle T., Coakley, Sean, Giacomotto, Jean, Blum, Ailisa, Joensuu, Merja, Wallis, Tristan P., Lo, Harriet P., Budnar, Srikanth, Rae, James, Ferguson, Charles, Bastiani, Michele, Thomas, Walter G., Pardon, Els, Steyaert, Jan, Yap, Alpha S., Goodhill, Geoffrey J., Hilliard, Massimo A., Parton, Robert G. and Meunier, Frédéric A. (2020). Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodies. Proceedings of the National Academy of Sciences of the United States of America, 117 (48), 30476-30487. doi: 10.1073/pnas.2007443117
Siegers, Jurre Y., Novakovic, Boris, Hulme, Katina D., Marshall, Rebecca, Bloxham, Conor J., Thomas, Walter G., Reichelt, Mellissa E., Leijten, Lonneke, van Run, Peter, Knox, Karen, Sokolowski, Kamil A., Tse, Brian W. C., Chew, Keng Yih, Christ, Angelika N., Howe, Greg, Bruxner, Timothy J. C., Karolyi, Mario, Pawelka, Erich, Koch, Rebecca M., Bellmann-Weiler, Rosa, Burkert, Francesco, Weiss, Günter, Samanta, Romit J., Openshaw, Peter J. M., Bielefeldt-Ohmann, Helle, van Riel, Debby and Short, Kirsty R. (2020). A high fat diet increases influenza A virus-associated cardiovascular damage. The Journal of infectious diseases, 222 (5), 820-831. doi: 10.1093/infdis/jiaa159
Bloxham, Conor J., Foster, Simon R. and Thomas, Walter G. (2020). A bitter taste in your heart. Frontiers in Physiology, 11 431, 431. doi: 10.3389/fphys.2020.00431
Alexander, Stephen P. H., Christopoulos, Arthur, Davenport, Anthony P., Kelly, Eamonn, Mathie, Alistair, Peters, John A., Veale, Emma L., Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Pawson, Adam J., Sharman, Joanna L., Southan, Christopher, Davies, Jamie A., Abbracchio, Maria P., Alexander, Wayne, Al-hosaini, Khaled, Bäck, Magnus, Beaulieu, Jean‐Martin, Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J.M., Blaho, Victoria, Bousquet, Corinne, Bräuner-Osborne, Hans, Burnstock, Geoffrey, Caló, Girolamo, Castaño, Justo P., Catt, Kevin J. ... Yao, Chengcan (2019). The Concise Guide to Pharmacology 2019/20: G protein‐coupled receptors. British Journal of Pharmacology, 176 (S1), S21-S141. doi: 10.1111/bph.14748
Ragnarsson, Lotten, Andersson, Åsa, Thomas, Walter G. and Lewis, Richard J. (2019). Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α1B- and β2-adrenoceptors. Science Signaling, 12 (572) eaas9485, eaas9485. doi: 10.1126/scisignal.aas9485
O'Brien, Shannon L., Johnstone, Elizabeth K. M., Devost, Dominic, Conroy, Jacinta, Reichelt, Melissa E., Purdue, Brooke W., Ayoub, Mohammed A., Kawai, Tatsuo, Inoue, Asuka, Eguchi, Satoru, Hébert, Terence E., Pfleger, Kevin D.G. and Thomas, Walter G. (2018). BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes. Biochemical Pharmacology, 158, 232-242. doi: 10.1016/j.bcp.2018.10.017
Mills, Richard J., Titmarsh, Drew M., Koenig, Xaver, Parker, Benjamin L., Ryall, James G., Quaife-Ryan, Gregory A., Voges, Holly K., Hodson, Mark P., Ferguson, Charles, Drowley, Lauren, Plowright, Alleyn T., Needham, Elise J., Wang, Qing-Dong, Gregorevic, Paul, Xin, Mei, Thomas, Walter G., Parton, Robert G., Nielsen, Lars K., Launikonis, Bradley S., James, David E., Elliott, David A., Porrello, Enzo R. and Hudson, James E. (2017). Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Proceedings of the National Academy of Sciences of the United States of America, 114 (40), E8372-E8381. doi: 10.1073/pnas.1707316114
Kaakinen, Mika, Reichelt, Melissa E., Ma, Zhibin, Ferguson, Charles, Martel, Nick, Porrello, Enzo R., Hudson, James E., Thomas, Walter G., Parton, Robert G. and Headrick, John P. (2017). Cavin-1 deficiency modifies myocardial and coronary function, stretch responses and ischaemic tolerance: roles of NOS over-activity. Basic Research in Cardiology, 112 (3) 24, 24. doi: 10.1007/s00395-017-0613-6
Kamato, Danielle, Mitra, Partha, Davis, Felicity, Osman, Narin, Chaplin, Rebecca, Cabot, Peter J., Afroz, Rizwana, Thomas, Walter, Zheng, Wenhua, Kaur, Harveen, Brimble, Margaret and Little, Peter J. (2017). Gaq proteins: molecular pharmacology and therapeutic potential. Cellular and Molecular Life Sciences, 74 (8), 1379-1390. doi: 10.1007/s00018-016-2405-9
Iyer, Swati, Chhabra, Yash, Harvey, Tracey J., Wang, Richard, Chiu, Han Sheng, Smith, A. G., Thomas, Walter G., Pennisi, David J. and Piper, Michael (2017). CRIM1 is necessary for coronary vascular endothelial cell development and homeostasis. Journal of Molecular Histology, 48 (1), 53-61. doi: 10.1007/s10735-016-9702-3
Reichelt, Melissa E., O'Brien, Shannon, Thomas, Walter G. and Headrick, John P. (2017). Transactivation of the epidermal growth factor receptor in responses to myocardial stress and cardioprotection. International Journal of Biochemistry and Cell Biology, 83, 97-110. doi: 10.1016/j.biocel.2016.12.014
Little, P. J., Hollenberg, M. D, Kamato, D., Thomas, W., Chen, J., Wang, T., Zheng, W. and Osman, N. (2016). Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling. British Journal of Pharmacology, 173 (20), 2992-3000. doi: 10.1111/bph.13398
Iyer, Swati, Chou, Fang Yu, Wang, Richard, Chiu, Han Sheng, Raju, Vinay K. Sundar, Little, Melissa H., Thomas, Walter G., Piper, Michael and Pennisi, David J. (2016). Crim1 has cell-autonomous and paracrine roles during embryonic heart development. Scientific Reports, 6 (1) 19832, 19832 .1-19832 .15. doi: 10.1038/srep19832
Forrester, Steven J., Kawai, Tatsuo, O'Brien, Shannon, Thomas, Walter, Harris, Raymond C. and Eguchi, Satoru (2016). Epidermal growth factor receptor transactivation: mechanisms, pathophysiology, and potential therapies in the cardiovascular system. Annual Review of Pharmacology and Toxicology, 56 (1), 627-653. doi: 10.1146/annurev-pharmtox-070115-095427
Roura, Eugeni, Foster, Simon, Winklebach, Anja, Navarro, Marta, Thomas, Walter, Campbell, Katrina and Stowasser, Michael (2016). Taste and hypertension in humans: targeting cardiovascular disease. Current Pharmaceutical Design, 22 (15), 2290-2305. doi: 10.2174/1381612822666160216151545
Karnik, Sadashiva S., Unal, Hamiyet, Kemp, Jacqueline R., Tirupula, Kalyan C., Eguchi, Satoru, Vanderheyden, Patrick M. L. and Thomas, Walter G. (2015). Angiotensin receptors: Interpreters of pathophysiological angiotensinergic stimulis. Pharmacological Reviews, 67 (4), 754-819. doi: 10.1124/pr.114.010454
Roura, Eugeni, Aldayyani, Asya, Thavaraj, Pridhuvi, Prakash, Sangeeta, Greenway, Delma, Thomas, Walter G., Meyerhof, Wolfgang, Roudnitzky, Natacha and Foster, Simon R. (2015). Variability in human bitter taste sensitivity to chemically diverse compounds can be accounted for by differential TAS2R activation. Chemical Senses, 40 (6), 427-435. doi: 10.1093/chemse/bjv024
Hirst, Daniel J., Lee, Tzong-Hsien, Pattenden, Leonard K., Thomas, Walter G. and Aguilar, Marie-Isabel (2015). Helix 8 of the angiotensin- II type 1A receptor interacts with phosphatidylinositol phosphates and modulates membrane insertion. Scientific Reports, 5 (1) 9972, 1-14. doi: 10.1038/srep09972
Foster, Simon R., Porrello, Enzo R., Stefani, Maurizio, Smith, Nicola J., Molenaar, Peter, Dos Remedios, Cristobal G., Thomas, Walter G. and Ramialison, Mirana (2015). Cardiac gene expression data and in silico analysis provide novel insights into human and mouse taste receptor gene regulation. Naunyn-Schmiedeberg's Archives of Pharmacology, 388 (10) 1118, 1009-1027. doi: 10.1007/s00210-015-1118-1
Clayton, Daniel, Hanchapola, Iresha, Thomas, Walter G., Widdop, Robert E., Smith, Alexander I., Perlmutter, Patrick and Aguilar, Marie-Isabel (2015). Structural determinants for binding to angiotensin converting enzyme 2 (ACE2) and angiotensin receptors 1 and 2. Frontiers in Pharmacology, 6 (JAN) 05, 5.1-5.9. doi: 10.3389/fphar.2015.00005
Foster, Simon R, Roura, Eugeni, Molenaar, Peter and Thomas, Walter G. (2015). G protein-coupled receptors in cardiac biology: old and new receptors. Biophysical Reviews, 7 (1), 77-89. doi: 10.1007/s12551-014-0154-2
Ragnarsson, Lotten, Andersson, Åsa, Thomas, Walter G. and Lewis, Richard J. (2015). Extracellular surface residues of theα1b-adrenoceptor critical for g protein -coupled receptor functions. Molecular Pharmacology, 87 (1), 121-129. doi: 10.1124/mol.114.094557
Foster, Simon R., Blank, Kristina, See Hoe, Louise E., Behrens, Maik, Meyerhof, Wolfgang, Peart, Jason N. and Thomas, Walter G. (2014). Bitter taste receptor agonists elicit G-protein-dependent negative inotropy in the murine heart. FASEB Journal, 28 (10), 4497-4508. doi: 10.1096/fj.14-256305
Foster, Simon R., Roura, Eugeni and Thomas, Walter G. (2014). Extrasensory perception: odorant and taste receptors beyond the nose and mouth. Pharmacology and Therapeutics, 142 (1), 41-61. doi: 10.1016/j.pharmthera.2013.11.004
George, Amee J., Purdue, Brooke W., Gould, Cathryn M., Thomas, Daniel W., Handoko, Yanny, Qian, Hongwei, Quaife-Ryan, Gregory A., Morgan, Kylie A., Simpson, Kaylene J., Thomas, Walter G. and Hannan, Ross D. (2013). A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation. Journal of Cell Science, 126 (23), 5377-5390. doi: 10.1242/jcs.128280
Foster, Simon R., Porrello, Enzo R., Purdue, Brooke, Chan, Hsiu-Wen, Voigt, Anja, Frenzel, Sabine, Hannan, Ross D., Moritz, Karen M., Simmons, David G., Molenaar, Peter, Roura, Eugeni, Boehm, Ulrich, Meyerhof, Wolfgang and Thomas, Walter G. (2013). Expression, Regulation and Putative Nutrient-Sensing Function of Taste GPCRs in the Heart. PLoS ONE, 8 (5) e64579, e64579-1-e64579-10. doi: 10.1371/journal.pone.0064579
Wang, Xiao, Wang, Lingdi, Zhu, Lu, Pan, Yi, Xiao, Fei, Liu, Weizhong, Wang, Zhenzhen, Guo, Feifan, Liu, Yong, Thomas, Walter G. and Chen, Yan (2013). PAQR3 modulates insulin signaling by shunting phosphoinositide 3-kinase p110α to the Golgi apparatus. Diabetes, 62 (2), 444-456. doi: 10.2337/db12-0244
Palma-Rigo, Kesia, Bassi, Jaspreet K., Nguyen-Huu, Thu-Phuc, Jackson, Kristy L., Davern, Pamela J., Chen, Daian, Elghozi, Jean-Luc, Thomas, Walter G., Allen, Andrew M. and Head, Geoffrey A. (2012). Angiotensin 1A receptors transfected into caudal ventrolateral medulla inhibit baroreflex gain and stress responses. Cardiovascular Research, 96 (2), 330-339. doi: 10.1093/cvr/cvs252
Callander, Gabrielle E., Ma, Sherie, Ganella, Despina E., Wimmer, Verena C., Gundlach, Andrew L., Thomas, Walter G. and Bathgate, Ross A. D. (2012). Silencing relaxin-3 in nucleus incertus of adult rodents: A viral vector-based approach to investigate neuropeptide function. PLoS One, 7 (8 Article. No.e42300) e42300, e42300. doi: 10.1371/journal.pone.0042300
Sevigny, Charles P., Bassi, Jaspreet, Williams, David A., Anderson, Colin R., Thomas, Walter G. and Allen, Andrew M. (2012). Efferent projections of C3 adrenergic neurons in the rat central nervous system. Journal of Comparative Neurology, 520 (11), 2352-2368. doi: 10.1002/cne.23041
Jang, Yujin, Soekmadji, Carolina, Mitchell, Justin M., Thomas, Walter G. and Thorn, Peter (2012). Real-time measurement of F-Actin remodelling during exocytosis using Lifeact-EGFP transgenic animals. Plos One, 7 (7) e39815, e39815.1-e39815.7. doi: 10.1371/journal.pone.0039815
Jin, Ting, Ding, Quirong, Huang, Heng, Xu, Daqian, Jiang, Yuhui, Zhou, Ben, Li, Zhenghu, Jiang, Xiaomeng, He, Jing, Liu, Weizhong, Zhang, Yixuan, Pan, Yi, Wang, Zhezhen, Thomas, Walter G. and Chen, Yan (2012). PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus. Cell Research, 22 (4), 661-676. doi: 10.1038/cr.2011.161
Chen, Daian, Jancovski, Nikola, Bassi, Jaspreet K., Nguyen-Huu, Thu-Phuc, Choong, Yan-Ting, Palma-Rigo, Kesia, Davern, Pamela J., Gurley, Susan B., Thomas, Walter G., Head, Geoffrey A. and Allen, Andrew M. (2012). Angiotensin type 1A receptors in C1 neurons of the rostral ventrolateral medulla modulate the pressor response to aversive stress. Journal of Neuroscience, 32 (6), 2051-2061. doi: 10.1523/JNEUROSCI.5360-11.2012
Porrello, Enzo R., Pfleger, Kevin D. G., Seeber, Ruth M., Qian, Hongwei, Oro, Cristina, Abogadie, Fe, Delbridge, Lea M. D. and Thomas, Walter G. (2011). Heteromerization of angiotensin receptors changes trafficking and arrestin recruitment profiles. Cellular Signalling, 23 (11), 1767-1776. doi: 10.1016/j.cellsig.2011.06.011
Bosnyak, Sanja, Jones, Emma S., Christopoulos, Arthur, Aguilar, Marie-Isabel, Thomas, Walter G. and Widdop, Robert E. (2011). Relative affinity of angiotensin peptides and novel ligands at AT(1) and AT(2) receptors. Clinical Science, 121 (7), 297-303. doi: 10.1042/CS20110036
O'Callaghan, E.L., Bassi, J.K., Porrello, E.R., Delbridge, L.M.D., Thomas, W.G. and Allen, A.M. (2011). Regulation of angiotensinogen by angiotensin II in mouse primary astrocyte cultures. Journal of Neurochemistry, 119 (1), 18-26. doi: 10.1111/j.1471-4159.2011.07406.x
Smith, Nicola J., Chan, Hsiu-Wen, Qian, Hongwei, Bourne, Allison M., Hannan, Katherine M, Warner, Fiona J., Ritchie, Rebecca H., Pearson, Richard B., Hannan, Ross D. and Thomas, Walter G. (2011). Determination of the exact molecular requirements for type 1 angiotensin receptor epidermal growth factor receptor transactivation and cardiomyocyte hypertrophy. Hypertension, 57 (5), 973-980. doi: 10.1161/HYPERTENSIONAHA.110.166710
Jones, Emma S., Del Borgo, Mark P., Kirsch, Julian F., Clayton, Daniel, Bosnyak, Sanja, Welungoda, Iresha, Hausler, Nicholas, Unabia, Sharon, Perlmutter, Patrick, Thomas, Walter G., Aguilar, Marie-Isabel and Widdop, Robert E. (2011). A single beta-amino acid substitution to angiotensin II confers AT(2) receptor selectivity and vascular function. Hypertension, 57 (3 Part 2), 570-576. doi: 10.1161/HYPERTENSIONAHA.110.164301
George, AJ, Thomas, WG and Hannan, RD (2010). The renin-angiotensin system and cancer: Old dog, new tricks. Nature Reviews Cancer, 10 (11), 745-759. doi: 10.1038/nrc2945
Du, Ann T., Onan, Döne, Dinh, Diem T., Lew, Michael J., Ziogas, James, Aguilar, Marie-Isabel, Pattenden, Leonard K. and Thomas, Walter G. (2010). Ligand-supported purification of the urotensin-II receptor. Molecular Pharmacology, 78 (4), 639-647. doi: 10.1124/mol.110.065151
Chen, DA, Bassi, JK, Walther, T, Thomas, WG and Allen, AM (2010). Expression of angiotensin type 1A receptors in C1 neurons restores the sympathoexcitation to angiotensin in the rostral ventrolateral medulla of angiotensin type 1A knockout mice. Hypertension, 56 (1), 143-150. doi: 10.1161/HYPERTENSIONAHA.110.151704
Lattin, J. E., Greenwood, K. P., Daly, N. L., Kelly, G, Zidar, D. A., Clark, R. J., Thomas, W. G., Kellie, Stuart, Craik, D. J., Hume, D. A. and Sweet, M. J. (2009). Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survival. Molecular Immunology, 47 (2-3), 340-347. doi: 10.1016/j.molimm.2009.09.012
Porrello, Enzo R, Meeker, William F, Thomas, Walter G, Widdop, Robert E and Delbridge, Lea MD (2009). Glucocorticoids Suppress Growth in Neonatal Cardiomyocytes Co-Expressing AT(2) and AT(1) Angiotensin Receptors. Neonatology, 97 (3), 257-265. doi: 10.1159/000253757
Ballinger, M. L., Ivey, M. E., Osman, N., Thomas, W. G. and Little, P. J. (2009). Endothelin-1 activates ETA receptors on human vascular smooth muscle cells to yield proteoglycans with increased binding to LDL. Atherosclerosis, 205 (2), 451-457. doi: 10.1016/j.atherosclerosis.2009.01.024
Callander, Gabrielle E., Thomas, Walter G. and Bathgate, Ross A. D. (2009). Prolonged RXFP1 and RXFP2 signaling can be explained by poor internalization and a lack of beta-arrestin recruitment. American Journal of Physiology - Cell Physiology, 296 (5), C1058-C1066. doi: 10.1152/ajpcell.00581.2008
Drew, Brian G., Duffy, Stephen J., Formosa, Melissa F., Natoli, Alaina K., Henstridge, Darren C., Penfold, Sally A., Thomas, Walter G., Mukhamedova, Nigora, de Courten, Barbora, Forbes, Josephine M., Yap, Felicia Y., Kaye, David M., van Hall, Gerrit, Febbraio, Mark A., Kemp, Bruce E., Sviridov, Dmitri, Steinberg, Gregory R. and Kingwell, Bronwyn A. (2009). High-density lipoprotein modulates glucose metabolism in patients with type 2 diabetes mellitus. Circulation, 119 (15), 2103-2111. doi: 10.1161/CIRCULATIONAHA.108.843219
Huynh, J., Thomas, W. G., Aguilar, M. I. and Pattenden, L. K. (2009). Role of helix 8 in G protein-coupled receptors based on structure-function studies on the type 1 angiotensin receptor. Molecular and Cellular Endocrinology, 302 (2), 118-127. doi: 10.1016/j.mce.2009.01.002
Callander, G. E., Thomas, W. G. and Bathgate, R. A. D. (2009). Development and Optimization of MicroRNA against Relaxin-3. Annals of the New York Academy of Sciences, 1160 (Relaxin and Related Peptides: Fifth International Conference), 261-264. doi: 10.1111/j.1749-6632.2008.03816.x
Porrello, Enzo R., Bell, James R., Schertzer, Jonathan D., Curl, Claire L., McMullen, Julie R., Mellor, Kimberley M., Ritchie, Rebecca H., Lynch, Gordon S., Harrap, Stephen B., Thomas, Walter G. and Delbridge, Lea M. D. (2009). Heritable pathologic cardiac hypertrophy in adulthood is preceded by neonatal cardiac growth restriction. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 296 (3), R672-R680. doi: 10.1152/ajpregu.90919.2008
Aranguiz-Urroz, Pablo, Soto, Dagoberto, Contreras, Ariel, Troncoso, Rodrigo, Chiong, Mario, Montenegro, Jose, Venegas, Daniel, Smolic, Christian, Ayala, Pedro, Thomas, Walter G., Lavandero, Sergio and Diaz-Araya, Guillermo (2009). Differential Participation of Angiotensin II Type 1 and 2 Receptors in the Regulation of Cardiac Cell Death Triggered by Angiotensin II. American Journal of Hypertension, 22 (5), 569-576. doi: 10.1038/ajh.2009.32
Porrello, Enzo R., Delbridge, Lea M. D. and Thomas, Walter G. (2009). The angiotensin II type 2 (AT(2)) receptor: an enigmatic seven transmembrane receptor. Frontiers in Bioscience, 14 (3), 958-972. doi: 10.2741/3289
Porrello, Enzo R., D'Amore, Angelo, Curl, Claire L., Allen, Andrew M., Harrap, Stephen B., Thomas, Walter G. and Delbridge, Lea M. D. (2009). Angiotensin II Type 2 Receptor Antagonizes Angiotensin II Type 1 Receptor-Mediated Cardiomyocyte Autophagy. Hypertension, 53 (6), 1032-1040. doi: 10.1161/HYPERTENSIONAHA.108.128488
Sanij, Elaine, Poortinga, Gretchen, Sharkey, Kerith, Hung, Sandy, Holloway, Timothy P., Ouin, Jaclyn, Robb, Elysia, Wong, Lee H., Thomas, Walter G., Stefanovsky, Victor, Moss, Tom, Rothblum, Lawrence, Hannan, Katherine M., McArthur, Grant A., Pearson, Richard B. and Hannan, Ross D. (2008). UBF levels determine the number of active ribosomal RNA genes in mammals. The Journal of Cell Biology, 183 (7), 1259-1274. doi: 10.1083/jcb.200805146
Vivar, Raul, Soto, C, Copaja, M, Mateluna, F, Aranguiz, P, Munoz, J P, Chiong, M, Garcia, L, Letelier, A, Thomas, W G, Lavandero, S and Diaz-Araya, G (2008). Phospholipase C/Protein kinase C pathway Mediates Angiotensin ll-Dependent Apoptosis in Neonatal Rat cardiac Fibroblasts Expressing AT1 Receptor. Journal of Cardiovascular Pharmacology, 52 (2), 184-190. doi: 10.1097/FJC.0b013e318181fadd
Bathgate, R. A. D., Lekgabe, E. D., McGuane, J. T., Su, Y., Pham, T., Ferraro, T., Layfield, S., Hannan, R. D., Thomas, W. G., Samuel, C. S. and Du, X.-J. (2008). Adenovirus-mediated delivery of relaxin reverses cardiac fibrosis. Molecular and Cellular Endocrinology, 280 (1-2), 30-38. doi: 10.1016/j.mce.2007.09.008
Pattenden, Leonard K. and Thomas, Walter G. (2007). Amylose affinity chromatography of maltose-binding protein: Purification by both native and novel matrix-assisted dialysis refolding methods. Methods in Molecular Biology, 421, 169-189.
Oro, Cristina, Qian, Hongwei and Thomas, Walter G. (2007). Type 1 angiotensin receptor pharmacology: Signaling beyond G proteins. Pharmacology & Therapeutics, 113 (1), 210-226. doi: 10.1016/j.pharmthera.2006.10.001
Chan, Hsiu-Wen, Jenkins, Anna, Pipolo, Luisa, Hannan, Ross D., Thomas, Walter G. and Smith, Nicola J. (2006). Effect of dominant-negative epidermal growth factor receptors on cardiomyocyte hypertrophy. Journal of Receptor Signal Transduction, 26 (5-6), 659-677. doi: 10.1080/10799890600923187
Pfleger, Kevin D. G., Dromey, Jasmin R., Dalrymple, Matthew B., Lim, Esther M. L., Thomas, Walter G. and Eidne, Karin A. (2006). Extended bioluminescence resonance energy transfer (eBRET) for monitoring prolonged protein–protein interactions in live cells. Cellular Signalling, 18 (10), 1664-1670. doi: 10.1016/j.cellsig.2006.01.004
Carey, Andrew L., Steinberg, Gregory R., Macaulay, S. Lance, Thomas, Walter G., Holmes, Anna G., Ramm, Georg, Prelovsek, Oja, Hohnen-Behrens, Cordula, Watt, Matthew J., James, David E., Kemp, Bruce E., Pedersen, Bente K. and Febbraio, Mark A. (2006). Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes, 55 (10), 2688-2697. doi: 10.2337/db05-1404
Policha, Aleksandra, Daneshtalab, Noriko, Chen, Lina, Dale, Lianne B., Altier, Christophe, Khosravani, Houman, Thomas, Walter G., Zamponi, Gerald W. and Ferguson, Stephen S. G. (2006). Role of angiotensin II type 1A receptor phosphorylation, phospholipase D, and extracellular calcium in isoform-specific protein kinase C membrane translocation responses. The Journal of Biological Chemistry, 281 (36), 26340-26349. doi: 10.1074/jbc.M605437200
Smith, Ian, Lew, Rebecca, Thomas, Walter G. and Tochon-Danguy, Nathalie (2006). Protein kinase C regulates the cell surface activity of endothelin-converting enzyme-1. International journal of peptide research and therapeutics, 12 (3), 291-295. doi: 10.1007/s10989-006-9034-3
Allen, Andrew M., Dosanjh, Jaspreet, Dassanayake, Sashikala, Tan, Geraldine and Thomas, Walter G. (2006). Baroreceptor reflex stimulation does not induce cytomegalovirus promoter-driven transgene expression in the ventrolateral medulla in vivo. Autonomic Neuroscience: Basic and Clinical, 126-127, 150-155. doi: 10.1016/j.autneu.2006.02.024
Watt, Matthew J., Dzamko, Nicolas, Thomas, Walter G., Rose-John, Stefan, Ernst, Matthias, Carling, David, Kemp, Bruce E., Febbraio, Mark A. and Steinberg, Gregory R. (2006). CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nature Medicine, 12 (5), 541-548. doi: 10.1038/nm1383
Di Nicolantonio, R., Kostka, V., Kwitek, A., Jacob, H., Thomas, W. G. and Harrap, S. B. (2006). Fine mapping of Lvm1: a quantitative trait locus controlling heart size independently of blood pressure. Pulmonary Pharmacology & Therapeutics, 19 (1), 70-73. doi: 10.1016/j.pupt.2005.02.010
Chan, Hsiu-Wen, Smith, Nicola J., Hannan, Ross D. and Thomas, Walter G. (2006). Tackling the EGFR in pathological tissue remodelling. Pulmonary Pharmacology and Therapeutics, 19 (1), 74-78. doi: 10.1016/j.pupt.2005.04.005
Porrello, E. R., Curl, C. L., Harrap, S. B., Thomas, W. G. and Delbridge, L. M. D. (2006). Post-natal cardiac development in an experimental model of normotensive cardiac hypertrophy. Journal of Molecular and Cellular Cardiology, 41 (4), 744-744. doi: 10.1016/j.yjmcc.2006.06.047
Allen, A. M., Dosanjh, J. K., Erac, M., Dassanayake, S., Hannan, R. D. and Thomas, W. G. (2006). Expression of Constitutively Active Angiotensin Receptors in the Rostral Ventrolateral Medulla Increases Blood Pressure. Hypertension, 47 (6), 1054-1061. doi: 10.1161/01.HYP.0000218576.36574.54
D’Amore, Angelo, Black, M. Jane and Thomas, Walter G. (2005). The Angiotensin II Type 2 Receptor Causes Constitutive Growth of Cardiomyocytes and Does Not Antagonize Angiotensin II Type 1 Receptor–Mediated Hypertrophy. Hypertension, 46 (6), 1347-1354. doi: 10.1161/01.HYP.0000193504.51489.cf
Corstius, Hugo Brandt, Zimanyi, Monika A., Maka, Noori, Herath, Thiloshini, Thomas, Walter, Van Der Laarse, Arnoud, Wreford, Nigel G. and Black, M. Jane (2005). Effect of intrauterine growth restriction on the number of cardiomyocytes in rat hearts. Pediatric Research, 57 (6), 796-800. doi: 10.1203/01.PDR.0000157726.65492.CD
Mifune, M., Ohtsu, H., Suzuki, H., Nakashima, H., Brailoiu, E., Dun, N. J., Frank, G. D., Inagami, T., Higashiyama, S., Thomas, W. G., Eckhart, A. D., Dempsey, P. J. and Eguchi, S. (2005). G Protein Coupling and Second Messenger Generation Are Indispensable for Metalloprotease-dependent, Heparin-binding Epidermal Growth Factor Shedding Through Angiotensin II Type-1 Receptor. Journal of Biological Chemistry, 280 (28), 26592-26599. doi: 10.1074/jbc.M502906200
Thomas, Walter G (2005). Double Trouble for Type 1 Angiotensin Receptors in Atherosclerosis. New England Journal of Medicine, 352 (5), 506-508. doi: 10.1056/NEJMcibr043928
Dinh, Diem T., Qian, Hongwei, Seeber, Ruth, Lim, Esther, Pfleger, Kevin, Eidne, Karin A. and Thomas, Walter G. (2005). Helix I of β-Arrestin Is Involved in Postendocytic Trafficking but Is Not Required for Membrane Translocation, Receptor Binding, and Internalization. Molecular Pharmacology, 67 (2), 375-382. doi: 10.1124/mol.104.004721
Kamimori, Hiroshi, Unabia, Sharon, Thomas, Walter G. and Aguilar, Marie-Isabel (2005). Evaluation of the membrane-binding properties of the proximal region of the angiotensin II receptor (AT1A) carboxyl terminus by surface plasmon resonance. Analytical Sciences, 21 (2), 171-174. doi: 10.2116/analsci.21.171
Zhang, Liping, Cheng, Jizhong, Ma, Yewei, Thomas, Walter, Zhang, Jiqiang and Du, Jie (2005). Dual Pathways for Nuclear Factor kB Activation by Angiotensin II in Vascular Smooth Muscle Phosphorylation of p65 by IkB Kinase and Ribosomal Kinase. Circulation Research, 97 (10), 975-982. doi: 10.1161/01.RES.0000190589.52286.41
Smith N. J., Chan, H.-W., Osborne, J. E., Thomas, W. G. and Hannan, R. D. (2004). Hijacking epidermal growth factor receptors by angiotensin II: New possibilities for understanding and treating cardiac hypertrophy. Cellular and Molecular Life Sciences, 61 (21), 2695-2703. doi: 10.1007/s00018-004-4244-3
See, Fiona, Thomas, Walter, Way, Kerrie, Tzanidis, Alex, Kompa, Andrew, Lewis, Dion, Itescu, Silviu and Krum, Henry (2004). p38 mitogen-activated protein kinase inhibition improves cardiac function and attenuates left ventricular remodeling following myocardial infarction in the rat. Journal of the American College of Cardiology, 44 (8), 1679-1689. doi: 10.1016/j.jacc.2004.07.038
Kompa, A. R., Thomas, W. G., See, F., Tzanidis, A., Hannan, R. D. and Krum, H. (2004). Cardiovascular Role of Urotensin II: Effect of Chronic Infusion in the Rat. Peptides, 25 (10), 1783-1788. doi: 10.1016/j.peptides.2004.03.029
Kule, Chris E., Karoor, Vijaya, Day, Jonathan N. E., Thomas, Walter G., Baker, Kenneth M., Dinh, Diem, Acker, Kathleen A. and Booz, George W. (2004). Agonist-dependent internalization of the angiotensin II type one receptor (AT1): role of C-terminus phosphorylation in recruitment of β-arrestins. Regulatory Peptides, 120 (1-3), 141-148. doi: 10.1016/j.regpep.2004.03.001
Onan, Döne, Hannan, Ross D. and Thomas, Walter G. (2004). Urotensin II: the old kid in town. Trends in Endocrinology and Metabolism, 15 (4), 175-182. doi: 10.1016/j.tem.2004.03.007
Thomas, W. G., Qian, H. and Smith, N. J. (2004). When 6 is 9: ‘Uncoupled’ AT 1 receptors turn signalling on its head. Cellular and Molecular Life Sciences, 61 (21), 2687-2694. doi: 10.1007/s00018-004-4245-2
Onan, Done, Pipolo, Luisa, Yang, Eunice, Hannan, Ross D. and Thomas, Walter G. (2004). Urotensin II Promotes Hypertrophy of Cardiac Myocytes via Mitogen-Activated Protein Kinases. Molecular Endocrinology, 18 (9), 2344-2354. doi: 10.1210/me.2003-0309
Tzanidis, Alex, Hannan, Ross D., Thomas, Walter G., Onan, Döne, Autelitano, Dominic J., See, Fiona, Kelly, Darren J., Gilbert, Richard E. and Krum, Henry (2003). Direct Actions of Urotensin II on the Heart Implications for Cardiac Fibrosis and Hypertrophy. Circulation Research, 93 (3), 246-253. doi: 10.1161/01.RES.0000084382.64418.BC
Thomas, Walter G. and Mendelsohn, Frederick A. O. (2003). Angiotensin receptors: form and function and distribution. International journal of biochemistry & cell biology, 35 (6), 774-779. doi: 10.1016/S1357-2725(02)00263-7
Autelitano, Dominic J., Ridings, Rebecca, Pipolo, Luisa and Thomas, Walter G. (2003). Adrenomedullin inhibits angiotensin AT1A receptor expression and function in cardiac fibroblasts. Regulatory Peptides, 112 (1-3), 131-137. doi: 10.1016/S0167-0115(03)00031-4
Thomas, Walter G. and Qian, Hongwei (2003). Arresting angiotensin type 1 receptors. Trends in Endocrinology & Metabolism, 14 (3), 130-136. doi: 10.1016/S1043-2760(03)00023-7
Mozsolits, Henriette, Thomas, Walter G. and Aguilar, Marie-Isabel (2003). Surface plasmon resonance spectroscopy in the study of membrane-mediated cell signalling. Journal of peptide science, 9 (2), 77-89. doi: 10.1002/psc.439
Wyse, B. D., Prior, I. A., Qian, H. W., Morrow, I. C., Nixon, S., Muncke, C., Kurzchalia, T. V., Thomas, W. G., Parton, R. G. and Hancock, J. F. (2003). Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane. Journal of Biological Chemistry, 278 (26), 23738-23746. doi: 10.1074/jbc.M212892200
Krum, Henry, Kompa, Andrew, Hannan, Ross and Thomas, Walter (2003). Emerging Role of the Urotensin II System in Cardiovascular Disease. Heart Drug, 3 (3), 153-158. doi: 10.1159/000072742
Smith, Nicola J., Hannan, Ross D., Thomas, Walter G. and Lew, Rebecca A. (2003). Angiotensin II mediates cardiomyocyte hypertrophic growth pathways via MMP-dependent HB-EGF liberation. Letters in Peptide Science, 10 (5), 431-435. doi: 10.1007/s10989-004-2398-3
Mozsolits, Henriette, Unabia, Sharon, Ahmad, Ariani, Morton, Craig J., Thomas, Walter G. and Aguilar, Marie-Isabel (2002). Electrostatic and Hydrophobic Forces Tether the Proximal Region of the Angiotensin II Receptor (AT1A) Carboxyl Terminus to Anionic Lipids. Biochemistry, 41 (24), 7830-7840. doi: 10.1021/bi0121813
Holloway, Alice C., Qian, Hongwei, Pipolo, Luisa, Ziogas, James, Miura, Shin-ichiro, Karnik, Sadashiva, Southwell, Bridget R., Lew, Michael J. and Walter G. Thomas (2002). Side-Chain Substitutions within Angiotensin II Reveal Different Requirements for Signaling, Internalization, and Phosphorylation of Type 1A Angiotensin Receptors. Molecular pharmacology, 61 (4), 768-777. doi: 10.1124/mol.61.4.768
Thomas, Walter G., Brandenburger, Yves, Autelitano, Dominic J., Pham, Thao, Qian, Hongwei and Hannan, Ross D. (2002). Adenoviral-Directed Expression of the Type 1A Angiotensin Receptor Promotes Cardiomyocyte Hypertrophy via Transactivation of the Epidermal Growth Factor Receptor.. Circulation research., 90 (2), 135-142. doi: 10.1161/hh0202.104109
Fabiani, M. E., Sourial, M., Thomas, W. G., Johnston, C. I. and Frauman, A. G. (2001). Angiotensin II enhances noradrenaline release from sympathetic nerves of the rat prostate via a novel angiotensin receptor: implications for the pathophysiology of benign prostatic hyperplasia. Journal of Endocrinology, 171 (1), 97-108. doi: 10.1677/joe.0.1710097
Hanyaloglu, Aylin C., Vrecl, Milka, Kroeger, Karen M., Miles, Lauren E. C., Qian, Hongwei, Thomas, Walter G. and Eidne, Karin A. (2001). Casein kinase II sites in the intracellular C-terminal domain of the thyrotropin-releasing hormone receptor and chimeric gonadotropin-releasing hormone receptors contribute to β-arrestin-dependent internalization. Journal of Biological Chemistry, 276 (21), 18066-18074. doi: 10.1074/jbc.M009275200
Qian, HW, Pipolo, L and Thomas, WG (2001). Association of β-arrestin 1 with the type 1A angiotensin II receptor involves phosphorylation of the receptor carboxyl terminus and correlates with receptor internalization. Molecular Endocrinology, 15 (10), 1706-1719. doi: 10.1210/me.15.10.1706
Thomas, Walter G., Qian, Hongwei W., Chang, Chang-Sheng and Karnik, Sadashiva (2000). Agonist-induced phosphorylation of the angiotensin II (AT1A) receptor requires generation of a conformation that is distinct from the inositol phosphate-signaling state. Journal of Biological Chemistry, 275 (4), 2893-2900. doi: 10.1074/jbc.275.4.2893
Qian, HW, Pipolo, L and Thomas, WG (1999). Identification of protein kinase C phosphorylation sites in the angiotensin II (AT(1A)) receptor. Biochemical Journal, 343 (3), 637-644. doi: 10.1042/0264-6021:3430637
Thomas, WG (1999). New aspects of angiotensin receptor regulation: Implications for other seven transmembrane-spanning receptors.. Protein and Peptide Letters, 6 (5), 305-317.
Thomas, WG, Pipolo, L and Qian, HW (1999). Identification of a Ca2+/calmodulin-binding domain within the carboxyl-terminus of the angiotensin II (AT(1A)) receptor. FEBS Letters, 455 (3), 367-371. doi: 10.1016/S0014-5793(99)00904-7
Thomas, Walter G. (1999). Regulation of angiotensin II type 1 (AT1) receptor function. Regulatory Peptides, 79 (1), 9-23. doi: 10.1016/S0167-0115(98)00140-2
Thomas, WG, Motel, TJ, Kule, CE, Karoor, V and Baker, KM (1998). Phosphorylation of the angiotensin II (AT(1A)) receptor carboxyl terminus: A role in receptor endocytosis. Molecular Endocrinology, 12 (10), 1513-1524. doi: 10.1210/me.12.10.1513
Thekkumkara, TJ, Thomas, WG, Motel, TJ and Baker, KM (1998). Functional role for the angiotensin II receptor (AT(1A)) 3 '-untranslated region in determining cellular responses to agonist: evidence for recognition by RNA binding proteins. Biochemical Journal, 329 (2), 255-264. doi: 10.1042/bj3290255
Thomas, W. G., Thekkumkara, T. J. and Baker, K. M. (1996). Cardiac effects of AII: AT1A Receptor Signaling, Desensitization, and Internalization. Advances in Experimental Medicine and Biology, 396, 59-69.
Thomas, WG, Thekkumkara, TJ and Baker, KM (1996). Molecular mechanisms of angiotensin II (AT(1A)) receptor endocytosis. Clinical and Experimental Pharmacology and Physiology, 23, S74-S80.
Thomas, WG, Baker, KM, Booz, GW and Thekkumkara, TJ (1996). Evidence against a role for protein kinase C in the regulation of the angiotensin II (AT1A) receptor. European Journal of Pharmacology, 295 (1), 119-122. doi: 10.1016/0014-2999(95)00732-6
Thomas, WG, Kerr, D and Sernia, C (1995). Molecular forms of rat angiotensinogen in plasma and brain: identification by isoelectric focusing and immunoblot analysis. Regulatory Peptides, 59 (1), 31-41. doi: 10.1016/0167-0115(95)00071-I
Thomas, WG, Baker, KM, Motel, TJ and Thekkumkara, TJ (1995). Angiotensin-Ii Receptor Endocytosis Involves 2 Distinct Regions Ef the Cytoplasmic Tail - a Role for Residues On the Hydrophobic Face of a Putative Amphipathic Helix. Journal of Biological Chemistry, 270 (38), 22153-22159. doi: 10.1074/jbc.270.38.22153
Bhat, GJ, Thekkumkara, TJ, Thomas, WG, Conrad, KM and Baker, KM (1995). Activation of the Stat Pathway by Angiotensin-Ii in T3Cho/at(1A) Cells - Cross-Talk Between Angiotensin-Ii and Interleukin-6 Nuclear Signaling. Journal of Biological Chemistry, 270 (32), 19059-19065. doi: 10.1074/jbc.270.32.19059
Thomas, Walter G., Thekkumkara, Thomas J., Motel, Thomas J. and Baker, Kenneth M. (1995). Stable expression of a truncated AT1A receptor in CHO-K1 cells: the carboxyl-terminal region directs agonist-induced internalization but not receptor signaling or desensitization. Journal of Biological Chemistry, 270 (1), 207-213. doi: 10.1074/jbc.270.1.207
Thekkumkara, TJ, Du, J, Dostal, DE, Motel, TJ, Thomas, WG and Baker, KM (1995). Stable expression of a functional rat angiotensin II (AT1A) receptor in CHO-K1 cells: Rapid desensitization by angiotensin II. Molecular and Cellular Biochemistry, 146 (1), 79-89. doi: 10.1007/BF00926885
Bhat, G. Jayarama, Thekkumkara, Thomas J., Thomas, Walter G., Conrad, Kathleen M. and Baker, Kenneth M. (1994). Angiotensin II stimulates sis-inducing factor-like DNA binding activity: evidence that the AT1A receptor activates transcription factor-Stat91 and/or a related protein. Journal of Biological Chemistry, 269 (50), 31443-31449.
Sernia, C and Thomas, WG (1994). A Novel Inhibitory Role for Glucocorticoids in the Secretion of Angiotensinogen by C6 Glioma-Cells. Journal of Neurochemistry, 62 (4), 1296-1301. doi: 10.1046/j.1471-4159.1994.62041296.x
Thomas, WG, Greenland, KJ, Shinkel, TA and Sernia, C (1992). Angiotensinogen is secreted by pure rat neuronal cell cultures. Brain Research, 588 (2), 191-200. doi: 10.1016/0006-8993(92)91575-Y
Sernia, C, Shinkel, TA, Thomas, WG, Ho, Kky and Lincoln, D (1992). Angiotensinogen secretion by single rat pituitary cells: Detection by a reverse haemolytic plaque assay and cell identification by immunocytochemistry. Neuroendocrinology, 55 (3), 308-316. doi: 10.1159/000126130
Sernia, C, Thomas, WG and Gemmell, RT (1991). Oxytocin Receptors in the Mammary-Gland and Reproductive-Tract of a Marsupial, the Brushtail Possum (Trichosurus-Vulpecula). Biology of Reproduction, 45 (5), 673-679. doi: 10.1095/biolreprod45.5.673
Sernia, C, Gemmell, RT and Thomas, WG (1991). Effect of Intra-Ovarian Infusion of Oxytocin On Plasma Progesterone Concentrations in Pregnant Ewes. Journal of Reproduction and Fertility, 92 (2), 453-460. doi: 10.1530/jrf.0.0920453
Campbell, DJ, Sernia, C, Thomas, WG and Oldfield, BJ (1991). Immunocytochemical Localization of Angiotensinogen in Rat-Brain - Dependence of Neuronal Immunoreactivity On Method of Tissue Processing. Journal of Neuroendocrinology, 3 (6), 653-660. doi: 10.1111/j.1365-2826.1991.tb00330.x
THOMAS, WG and SERNIA, C (1990). THE IMMUNOCYTOCHEMICAL LOCALIZATION OF ANGIOTENSINOGEN IN THE RAT OVARY. Cell and Tissue Research, 261 (2), 367-373. doi: 10.1007/BF00318679
Sernia, C, Garciaaragon, J, Thomas, WG and Gemmell, RT (1990). Uterine oxytocin receptors in an australian marsupial, the brushtail possum, Trichosurus vulpecula. Comparative Biochemistry and Physiology -- Part A: Physiology, 95 (1), 135-138. doi: 10.1016/0300-9629(90)90021-J
Sernia, C, Lello, P and Thomas, WG (1990). Angiotensin receptors in an Australian marsupial, the brushtail possum Trichosurus vulpecula. General and Comparative Endocrinology, 77 (1), 116-126. doi: 10.1016/0016-6480(90)90212-5
Thomas, WG and Sernia, C (1990). Immunocytochemical Localization of Angiotensinogen and Angiotensin-Ii in the Rat Pituitary. Journal of Neuroendocrinology, 2 (3), 297-304. doi: 10.1111/j.1365-2826.1990.tb00408.x
Sernia, C, Gemmell, RT and Thomas, WG (1989). Oxytocin Receptors in the Ovine Corpus-Luteum. Journal of Endocrinology, 121 (1), 117-123. doi: 10.1677/joe.0.1210117
Thomas, WG and Sernia, C (1988). Immunocytochemical localization of angiotensinogen in the rat brain. Neuroscience, 25 (1), 319-341. doi: 10.1016/0306-4522(88)90029-2
Sernia, C, Davis, M and Thomas, WG (1986). Purification of Rat Angiotensinogen. Preparative Biochemistry, 16 (1), 45-59. doi: 10.1080/00327488608062458
Thomas, WG and Sernia, C (1985). Regulation of rat brain angiotensin II (AII) receptors by intravenous AII and low dietary Na+. Brain Research, 345 (1), 54-61. doi: 10.1016/0006-8993(85)90835-2
Sernia, C, Sinton, L, Thomas, WG and Pascoe, W (1985). Liver Angiotensin-Ii Receptors in the Rat - Binding-Properties and Regulation by Dietary Na+ and Angiotensin-II. Journal of Endocrinology, 106 (1), 103-111. doi: 10.1677/joe.0.1060103
Conference Papers
Griffiths, L., Ho, U., Burt, K., Watson, S., Patel, K., Bradford, J., Tan, C., Bhavsar, C., Palpant, N., Souza-Fonseca-Guimaraes, F., Wu, S., Reichelt, M. and Thomas, W. (2024). Trastuzumab-Induced Cardiotoxicity Involves Antibody Dependent Cell Cytotoxicity (ADCC). 72nd Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Perth, WA Australia, 1-4 August 2024. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2024.06.397
Reichelt, Melissa, Ho, Uda, Bunt, Kelsey, Watson, Sophie, Patel, Kinjal, Bradford, Julia and Thomas, Walter G. (2024). Targeting Cardiomyocytes with Adeno Associated Viruses to Protect Hearts from Trastuzumab-induced Cardiotoxicity. American Physiology Summit 2024, Long Beach, CA United States, 4-7 April 2024. Rockville, MD United States: American Physiological Society. doi: 10.1152/physiol.2024.39.s1.2480
Thomas, Walter G., Bloxham, Conor J., Dashwood, Alexander, Cheesman, Elizabeth, Hulme, Katina D., Khoo, Hui Y., Russell, Jake D., Yoshikawa, Yusuke, Reichelt, Melissa E., Short, Kirsty R., Furness, Sebastian B. G., Foster, Simon R. and Molenaar, Peter (2023). A bitter taste in your heart: cardiac cells expressing T2Rs and polymorhpisms that affect cardiac function. 45th Annual Meeting of the Association-for-Chemoreception-Sciences, Bonita Springs, FL, United States, 19-22 April 2023. Oxford, United Kingdom: Oxford University Press.
Bloxham, Conor, Foster, Simon and Thomas, Walter (2020). Naturally occurring, non-functional polymorphisms in cardiac T2R (bitter taste) receptors. 29th Annual Meeting of the European-Chemoreception-Research-Organization (ECRO), Trieste, Italy, 11-14 September 2019. Oxford, United Kingdom: Oxford University Press.
Reichelt, M., Wang, Z., Thorn, C., Paravicini, T. and Thomas, W. G. (2019). Cardiomyocyte ErbB4 receptors are essential for developmental cardiac hypertrophy and cardiac function in adult hearts. ESC Congress / World Congress of Cardiology, Paris, France, 31 August - 4 September 2019. Oxford, United Kingdom: Oxford University Press.
Hudson, J., Mills, R., Titmarsh, D., Koenig, X., Parker, B., Ryall, J., Quaife-Ryan, G., Voges, H., Hodson, M., Ferguson, C., Drowley, L., Plowright, A., Wang, Q., Gregorevic, P., Xin, M., Thomas, W., Parton, R., Nielsen, L., Launikonis, B., James, D., Elliott, D. and Porrello, E. (2017). Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Abstracts for the 65th Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, Perth, Australia, 10 - 13 August 2017. Chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2017.06.375
Ryan, Quaife-G., Ma, Z., Sim, C., Ramialison, M., Thomas, W., Hudson, J. and Porrello, E. (2016). Cellular transcriptomic analysis of multiple cardiac lineages during heart development and regeneration. 64th Cardiac Society of Australia and New Zealand Annual Scientific Meeting and the International Society for Heart Research Australasian Section Annual Scientific Meeting, Adelaide, SA Australia, 4 – 7 August 2016. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2016.06.079
Thomas, Walter (2016). TAS2Rs-A new class of functional G protein-coupled receptors in heart.. 25th Annual Meeting of the European-Chemoreception-Research-Organization (ECRO), Istanbul Turkey, Sep 01-05, 2015. OXFORD: OXFORD UNIV PRESS.
Foster, Simon R., Porrello, Enzo R., Stefani, Maurizio, Smith, Nicola J., Molenaar, Peter, dos Remedios, Cris G., Thomas, Walter G. and Ramialison, Mirana (2015). Transcriptional Regulation of Taste Receptor Genes: Novel Insights From In Silico and Cardiac Gene Expression Analyses. 15th Scientific Meeting of the Australasian Association for ChemoSensory Science (AACSS), Brisbane, QLD Australia, 03-05 December 2014. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/chemse/bjv008
Wang, Z., Chan, H. W., Thomas, W. G. and Paravicini, T. M. (2014). The function of ErbB4 receptor in the postnatal mouse heart. 35th Annual Scientific Meeting of the High Blood Pressure Research Council of Australia (HBPRCA) / 39th Annual Scientific Meeting of the Australian-Atherosclerosis-Society (AAS), Melbourne Australia, 05 - 07 December 2013. Philadelphia, PA United States: Lippincott Williams and Wilkins. doi: 10.1161/HYP.0000000000000010
Wang, Zhen, Chan, Hsiu-Wen, Chen, Chen, Thomas, Walter G. and Paravicini, Tamara M. (2013). Investigating the Role of Epidermal Growth Factor Receptors in Angiotensin II-induced Hypertrophic Signalling in Cardiomyocytes. American Heart Association High Blood Pressure Research Scientific Sessions, New Orleans La, 11-14 September 2013. Philadelphia, PA United States: Lippincott Williams and Wilkins.
George, Amee J., Hannan, Ross D. and Thomas, Walter G. (2013). Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches. The International Symposium ‘Ca2+ Signalling and Transport in Health and Disease’, Aarhus, Denmark, 19 - 20 June 2012. Chichester, West Sussex, United Kingdom: Wiley-Blackwell Publishing Ltd.. doi: 10.1111/febs.12509
George, A. J., Purdue, B. W., Gould, K., Handoko, Y., Thomas, D. W., Morgan, K. A., Simpson, K. J., Thomas, W. G. and Hannan, R. D. (2012). A functional SiRNA screening approach to investigate the mechanism underlying GPCR-mediated EGFR Transactivation in Malignancy. 22nd Biennial Congress of the European Association for Cancer Research, Barcelona Spain, 07-10 July 2012. Oxford, United Kingdom: Pergamon. doi: 10.1016/S0959-8049(12)71277-7
Cully, T. R., Purdue, B. W., Thomas, W. G., Gregorevic, P. and Launikonis, B. S. (2012). Injection of rAAV-Orai1 in adult wt and dystrophic mice up-regulates store operated calcium entry. Collaborative Congress of the European-Society-of-Gene-and-Cell-Therapy/French-Society-of-Cell-and-Gene-Therapy, Versailles, France, 25-29 October 2012. New Rochelle, NY, United States: Mary Ann Liebert.
Jones, E. S., DelBorgo, M., Bosnjak, S., Perlmutter, P., Thomas, W. G., Aguilar, M. I. and Widdop, R. E. (2012). Beta-amino acid substitution of angiotensin III imparts significant AT2 receptor selectivity and vascular function. 33rd Annual Scientific Meeting of the High-Blood-Pressure-Research-Council-of-Australia (HBPRCA), Perth, WA, Australia, 6-9 December 2011. Philadelphia, PA, United States: Lippincott Williams & Wilkins. doi: 10.1161/HYP.0b013e3182602164
O'Callaghan, E. L., Thomas, W. G. and Allen, A. M. (2011). Knockdown of Angiotensinogen Protein in Vivo. 32nd Annual Scientific Meeting of the High Blood Pressure Research Council of Australia, Melbourne Australia, Dec 01-03, 2010. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
Bosnyak, S., Jones, E. S., Kirsch, J. F., Del Borgo, M. P., Welungoda, I., Clayton, D., Hausler, N., Unabia, S., Perlmutter, P., Thomas, W. G., Aguilar, M-I and Widdop, R. E. (2011). SINGLE BETA-AMINO ACID SUBSTITUTIONS TO ANGIOTENSIN II CONFER AT2 RECEPTOR SELECTIVITY AND VASCULAR FUNCTION. 32nd Annual Scientific Meeting of the High Blood Pressure Research Council of Australia, Melbourne Australia, Dec 01-03, 2010. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
Chen, Daian, Thu-Phuc Nguyen-Huu, Bassi, Jaspreet K., Davern, Pamela, Thomas, Walter G., Head, Geoff A. and Allen, Andrew M. (2011). Role of angiotensin in the rostral ventrolateral medulla in the pressor response to aversive stress. Experimental Biology Meeting 2011, Washington Dc, Apr 09-13, 2011. BETHESDA: FEDERATION AMER SOC EXP BIOL.
Lei, C., MacRae, K., Thomas, W. and Sernia, C. (2011). UMR-106 osteoblast cells express components of the renin-angiotensin system and are regulated by glucocorticoids. 2nd Asia-Pacific Osteoporosis and Bone Meeting, Gold Coast , QLD Australia, 4th-8th September 2011.
MacRae, K, Thomas, W and Sernia C (2011). ANGIOTENSIN II INCREASES OSTEOBLAST RANKL:OPG RATIO THROUGH TRANSACTIVATION OF ERBB RECEPTORS BY EGF-LIKE LIGANDS. European Congress on Osteoporosis and Osteoarthritis – ESCEO11, Valencia Spain, 23-26 March 2011.
MacRae, Kirsty, Thomas, Walter and Senia, Conrad (2011). Angiotensin II increases osteoblast RANKL:OPG ratio through transactivation of ErbB receptors by EGF-like ligands. 1st IOF-ESCEO Pre-Clinical Symposium, Valencia, SPAIN, 23-26, 2011.
MacRae, K., Thomas, W. and Sernia C. (2011). Angiotensin II regulates RANKL:OPG ratio potentially through transactivation of ErbB receptors by EGF-like ligands. 2nd Asia-Pacific Osteoporosis and Bone Meeting, Gold Coast , QLD, Australia, 4th-8th September 2011. Springer.
Widdop, RE, Kirsch, J, Bosnyak, S, Unabia, S, Del Borgo, M, Perlmutter, P, Thomas, W, Aguilar, MI and Jones, ES (2010). Beta-amino acid substituted Angiotensin II peptidomimetics as AT2 receptor-selective ligands. Conference on High Blood Pressure Research, Washington, DC, U.S.A., 13-16 October 2010. Philadelphia, PA, U.S.A.: Lippincott Williams & Wilkins. doi: 10.1161/HYP.0b013e3181faa059
O'Callaghan, EL, Thomas, WG and Allen, AM (2010). REDUCED ANGIOTENSINOGEN GENE EXPRESSION FOLLOWING ANGIOTENSIN II STIMULATION OF ASTROCYTES EXPRESSING THE ANGIOTENSIN TYPE 1A RECEPTOR. 31st Annual Scientific Meeting of the High-Blood-Pressure-Research-Council-of-Australia, Sydney AUSTRALIA, DEC 01-03, 2009.
Bourne, Allison M., Hannan, Ross D. and Thomas, WG (2009). Potential roles of a disintegrin and metalloprotease proteins 10, 12, and 17 in angiotensin II-mediated transactivation of epidermal growth factor receptors. Basic Cardiovascular Sciences Conference 2009, Henderson NV, 20-23 July 2009. United States: Lippincott Williams & Wilkins. doi: 10.1161/RES.0b013e3181bcaeff
Chan, Hsiu-Wen, Jenkins, Anna, Pipolo, Luisa, Hannan, Ross D., Thomas, Walter G. and Smith, Nicola J. (2006). Effect of dominant-negative epidermal growth factor receptors on cardiomyocyte hypertrophy. 10th Swiss Receptor Workshop: "From Research to Therapeutics", Basel, Switzerland, 12-15 March 2006. New York, NY, U.S.A.: Marcel Dekker. doi: 10.1080/10799890600923187
Allen, Andrew M., Dosanjh, Jaspreet, Dassanayake, Sashikala, Tan, Geraldine and Thomas, Walter G. (2006). Baroreceptor reflex stimulation does not induce cytomegalovirus promoter-driven transgene expression in the ventrolateral medulla in vivo. 4th Congress of the International Society for Autonomic Neuroscience, Marseille, France, July, 2005. Amsterdam: Elsevier B.V.. doi: 10.1016/j.autneu.2006.02.024
Tzanidis, A, Hannan, RD, Thomas, WG, Onan, D, See, F and Krum, H (2001). Urotensin II stimulates collagen synthesis by cardiac fibroblasts and hypertrophic signalling in cardiomyocytes via G(alpha)q- and Ras-dependent pathways. NEW YORK: ELSEVIER SCIENCE INC.
Thomas, WG, Motel, TJ, Kule, CE and Baker, KM (1996). Angiotensin II receptor (AT(1A)) endocytosis involves phosphorylation of the carboxyl-terminus ''STL'' internalization motif.. DALLAS: AMER HEART ASSOC.
Thomas, WG, Thekkumkara, TJ and Baker, KM (1996). Cardiac effects of AII - AT(1A) receptor signaling, desensitization, and internalization. 1st International Symposium on the Cellular and Molecular Aspects of Angiotensin Receptors, Gainesville Fl, Dec 09-11, 1994. NEW YORK: PLENUM PRESS DIV PLENUM PUBLISHING CORP.
Thomas, WG, Baker, KM, Motel, TJ and Thekkumkara, TJ (1995). An Essential Role for Leu316 and Tyr319 in Angiotensin-Ii (Atia) Receptor Endocytosis. DALLAS: AMER HEART ASSOC.