Dr Adekunle Bademosi
Research Fellow - RAD-DARF
Queensland Brain Institute
Researcher biography
Dr Bademosi received his BSc(Hons) in Medical Physiology from the University of Lagos (Nigeria) in 2010, and his MSc and PhD in Neuroscience from the Queensland Brain Institute at the University of Queensland in 2014 and 2018 respectively. He pioneered super-resolution single-molecule microscopy in vivo during his PhD, where he examined nanoscale changes in synaptic proteins during neurotransmission and under general anaesthesia. In 2018, obtained the highly competitive European Molecular Biology Organisation (EMBO) postdoctoral fellowship.to carry out his postdoctoral training in the lab of Professor Patrik Verstreken who is the current Director of of the Centre for Brain and Disease Research, Flemish Institute of Biotechnology, KU Leuven, Belgium. Here, he characterised how disease coding variants in risk genes for Parkinson's Disease elicit onset of neuronal degeneration (published in Neuron). Dr Bademosi was awarded the inaugural Race Against Dementia - Dementia Australia Research Foundation postdoctoral fellowship in 2020, to carry examine advanced nanoscale investigation into changes in the organisation and dynamics of the Motor Neuron Disease and Frontotemporal Dementia linked protein TDP-43. His research has been supported by grants from the Brain Foundation Australia, Dementia Australia Research Foundation, Motor Neuron Disease Research Institute of Australia, and the Australian Research Council.
Book Chapter
Bademosi, Adekunle T. and Meunier, Frédéric A (2022). Unveiling the nanoscale dynamics of the exocytic machinery in chromaffin cells with single-molecule imaging. Chromaffin Cells. (pp. 311-327) edited by Ricardo Borges. New York, NY USA: Humana New York. doi: 10.1007/978-1-0716-2671-9_21
Journal Articles
Prior, Robert, Silva, Alessio, Vangansewinkel, Tim, Idkowiak, Jakub, Tharkeshwar, Arun Kumar, Hellings, Tom P, Michailidou, Iliana, Vreijling, Jeroen, Loos, Maarten, Koopmans, Bastijn, Vlek, Nina, Agaser, Cedrick, Kuipers, Thomas B, Michiels, Christine, Rossaert, Elisabeth, Verschoren, Stijn, Vermeire, Wendy, de Laat, Vincent, Dehairs, Jonas, Eggermont, Kristel, van den Biggelaar, Diede, Bademosi, Adekunle T, Meunier, Frederic A, vandeVen, Martin, Van Damme, Philip, Mei, Hailiang, Swinnen, Johannes V, Lambrichts, Ivo, Baas, Frank ... Van Den Bosch, Ludo (2024). PMP22 duplication dysregulates lipid homeostasis and plasma membrane organization in developing human Schwann cells. Brain, 147 (9), 3113-3130. doi: 10.1093/brain/awae158
Hines, Adam D., Kewin, Amber B., Van De Poll, Matthew N., Anggono, Victor, Bademosi, Adekunle T. and van Swinderen, Bruno (2024). Synapse-specific trapping of SNARE machinery proteins in the anesthetized Drosophila brain. The Journal of Neuroscience, 44 (24) e0588232024, 1-18. doi: 10.1523/jneurosci.0588-23.2024
San Gil, Rebecca, Pascovici, Dana, Venturato, Juliana, Brown-Wright, Heledd, Mehta, Prachi, Madrid San Martin, Lidia, Wu, Jemma, Luan, Wei, Chui, Yi Kit, Bademosi, Adekunle T., Swaminathan, Shilpa, Naidoo, Serey, Berning, Britt A., Wright, Amanda L., Keating, Sean S., Curtis, Maurice A., Faull, Richard L. M., Lee, John D., Ngo, Shyuan T., Lee, Albert, Morsch, Marco, Chung, Roger S., Scotter, Emma, Lisowski, Leszek, Mirzaei, Mehdi and Walker, Adam K. (2024). A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration. Nature Communications, 15 (1) 1508, 1508. doi: 10.1038/s41467-024-45646-9
Weeratunga, Saroja, Gormal, Rachel S., Liu, Meihan, Eldershaw, Denaye, Livingstone, Emma K., Malapaka, Anusha, Wallis, Tristan P., Bademosi, Adekunle T., Jiang, Anmin, Healy, Michael D., Meunier, Frederic A. and Collins, Brett M. (2024). Interrogation and validation of the interactome of neuronal Munc18-interacting Mint proteins with AlphaFold2. Journal of Biological Chemistry, 300 (1) 105541, 105541. doi: 10.1016/j.jbc.2023.105541
Liau, Wei-Siang, Zhao, Qiongyi, Bademosi, Adekunle, Gormal, Rachel S., Gong, Hao, Marshall, Paul R., Periyakaruppiah, Ambika, Madugalle, Sachithrani U., Zajaczkowski, Esmi L., Leighton, Laura J., Ren, Haobin, Musgrove, Mason, Davies, Joshua, Rauch, Simone, He, Chuan, Dickinson, Bryan C., Li, Xiang, Wei, Wei, Meunier, Frédéric A., Fernández-Moya, Sandra M., Kiebler, Michael A., Srinivasan, Balakumar, Banerjee, Sourav, Clark, Michael, Spitale, Robert C. and Bredy, Timothy W. (2023). Fear extinction is regulated by the activity of long noncoding RNAs at the synapse. Nature Communications, 14 (1) 7616, 1-16. doi: 10.1038/s41467-023-43535-1
Bademosi, Adekunle T., Decet, Marianna, Kuenen, Sabine, Calatayud, Carles, Swerts, Jef, Gallego, Sandra F., Schoovaerts, Nils, Karamanou, Spyridoula, Louros, Nikolaos, Martin, Ella, Sibarita, Jean-Baptiste, Vints, Katlijn, Gounko, Natalia V., Meunier, Frédéric A., Economou, Anastassios, Versées, Wim, Rousseau, Frederic, Schymkowitz, Joost, Soukup, Sandra-F. and Verstreken, Patrik (2023). EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation. Neuron, 111 (9), 1402-1422.e13. doi: 10.1016/j.neuron.2023.02.001
Keating, Sean S., Bademosi, Adekunle T., San Gil, Rebecca and Walker, Adam K. (2023). Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43. Cellular and Molecular Life Sciences, 80 (4) 95, 1-23. doi: 10.1007/s00018-023-04739-2
Bademosi, Adekunle T. and Walker, Adam K. (2022). Cryptic inclusions UNCover losses driving neurodegeneration. Trends in Genetics, 38 (9), 889-891. doi: 10.1016/j.tig.2022.06.004
Zhou, Yong, Ariotti, Nicholas, Rae, James, Liang, Hong, Tillu, Vikas, Tee, Shern, Bastiani, Michele, Bademosi, Adekunle T., Collins, Brett M., Meunier, Frederic A., Hancock, John F. and Parton, Robert G. (2021). Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae. Journal of Cell Biology, 220 (3) e202005138. doi: 10.1083/jcb.202005138
Gormal, Rachel S., Padmanabhan, Pranesh, Kasula, Ravikiran, Bademosi, Adekunle T., Coakley, Sean, Giacomotto, Jean, Blum, Ailisa, Joensuu, Merja, Wallis, Tristan P., Lo, Harriet P., Budnar, Srikanth, Rae, James, Ferguson, Charles, Bastiani, Michele, Thomas, Walter G., Pardon, Els, Steyaert, Jan, Yap, Alpha S., Goodhill, Geoffrey J., Hilliard, Massimo A., Parton, Robert G. and Meunier, Frédéric A. (2020). Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodies. Proceedings of the National Academy of Sciences of the United States of America, 117 (48), 30476-30487. doi: 10.1073/pnas.2007443117
Padmanabhan, Pranesh, Bademosi, Adekunle T., Kasula, Ravikiran, Lauwers, Elsa, Verstreken, Patrik and Meunier, Frédéric A. (2019). Need for speed: Super-resolving the dynamic nanoclustering of syntaxin-1 at exocytic fusion sites. Neuropharmacology, 169 107554, 107554. doi: 10.1016/j.neuropharm.2019.02.036
Li, Pin, Bademosi, Adekunle T., Luo, Jincai and Meunier, Frederic A. (2018). Actin remodeling in regulated exocytosis: toward a mesoscopic view. Trends in Cell Biology, 28 (9), 685-697. doi: 10.1016/j.tcb.2018.04.004
Bademosi, Adekunle T., Lauwers, Elsa, Amor, Rumelo, Verstreken, Patrik, van Swinderen, Bruno and Meunier, Frédéric A (2018). In vivo single-molecule tracking at the Drosophila presynaptic motor nerve terminal. Journal of Visualized Experiments, 2018 (131) e56952. doi: 10.3791/56952
Bademosi, Adekunle T. , Steeves, James, Karunanithi, Shanker, Zalucki, Oressia H, Gormal, Rachel S, Liu, Shu, Lauwers, Elsa, Verstreken, Patrik, Anggono, Victor, Meunier, Frederic A and van Swinderen, Bruno (2018). Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic. Cell reports, 22 (2), 427-440. doi: 10.1016/j.celrep.2017.12.054
Vanhauwaert, Roeland, Kuenen, Sabine, Masius, Roy, Bademosi, Adekunle, Manetsberger, Julia, Schoovaerts, Nils, Bounti, Laura, Gontcharenko, Serguei, Swerts, Jef, Vilain, Sven, Picillo, Marina, Barone, Paolo, Munshi, Shashini T., de Vrij, Femke M. S., Kushner, Steven A., Gounko, Natalia V., Mandemakers, Wim, Bonifati, Vincenzo, Meunier, Frederic A., Soukup, Sandra‐Fausia and Verstreken, Patrik (2017). The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals. EMBO Journal, 36 (10), 1392-1411. doi: 10.15252/embj.201695773
Bademosi, Adekunle T., Lauwers, Elsa, Padmanabhan, Pranesh, Odierna, Lorenzo, Chai, Ye Jin, Papadopulos, Andreas, Goodhill, Geoffrey J., Verstreken, Patrik, van Swinderen, Bruno and Meunier, Frédéric A (2017). Erratum: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters. Nature Communications, 8 (1) 14492. doi: 10.1038/ncomms14492
Bademosi, Adekunle T., Lauwers, Elsa, Padmanabhan, Pranesh, Odierna, Lorenzo, Chai, Ye Jin, Papadopulos, Andreas, Goodhill, Geoffrey J., Verstreken, Patrik, Van Swinderen, Bruno and Meunier, Frederic A. (2016). In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters. Nature Communications, 7 (1) 13660, 13660. doi: 10.1038/ncomms13660
Joensuu, Merja, Padmanabhan, Pranesh, Durisic, Nela, Bademosi, Adekunle T. D., Cooper-Williams, Elizabeth, Morrow, Isabel C., Harper, Callista B., Jung, WooRam, Parton, Robert G., Goodhill, Geoffrey J., Papadopulos, Andreas and Meunier, Frederic A. (2016). Subdiffractional tracking of internalized molecules reveals heterogeneous motion states of synaptic vesicles. Journal of Cell Biology, 215 (2), 277-292. doi: 10.1083/jcb.201604001
Kasula, Ravikiran, Chai, Ye Jin, Bademosi, Adekunle T., Harper, Callista B., Gormal, Rachel S., Morrow, Isabel C., Hosy, Eric, Collins, Brett M., Choquet, Daniel, Papadopulos, Andreas and Meunier, Frederic A. (2016). The Munc18-1 domain 3a hinge-loop controls syntaxin-1A nanodomain assembly and engagement with the SNARE complex during secretory vesicle priming. The Journal of Cell Biology, 214 (7) 847, 847-858. doi: 10.1083/jcb.201508118
Zalucki, Oressia H., Menon, Hareesh, Kottler, Benjamin, Faville, Richard, Day, Rebecca, Bademosi, Adekunle T., Lavidis, Nickolas, Karunanithi, Shanker and van Swinderen, Bruno (2015). Syntaxin1A-mediated resistance and hypersensitivity to isoflurane in Drosophila melanogaster. Anesthesiology, 122 (5), 1060-1074. doi: 10.1097/ALN.0000000000000629
Harper, Callista B., Bademosi, Adekunle T., Coulson, Elizabeth J. and Meunier, Frederic A. (2014). A role for SNAREs in neuronal survival?. Journal of Neurochemistry, 129 (5), 753-755. doi: 10.1111/jnc.12699
Conference Paper
Bademosi, Adekunle T. (2023). Pathogenic motor neuron disease‐linked mutations distinctly alter TDP‐43 nanoscale dynamics. Alzheimer's Association International Conference 2023, Amsterdam, Netherlands, 16-20 July 2023. Hoboken, NJ, United States: John Wiley & Sons. doi: 10.1002/alz.077661
Thesis
Bademosi, Adekunle Temitope Damola Daniel (2018). Control of neurotransmission by diffusional properties of a presynaptic plasma membrane protein - syntaxin1A. PhD Thesis, Queensland Brain Institute, The University of Queensland. doi: 10.14264/uql.2018.556