Professor Adam Walker
Affiliate of Clem Jones Centre for Ageing and Dementia Research
Clem Jones Centre for Ageing Dementia Research
Honorary Professor
Queensland Brain Institute
Professor Adam Walker: Neurodegeneration pathobiology
The Walker lab uses biochemistry and imaging techniques to study neuronal cell culture and genetically modified mouse models of MND and FTD, alongside analysis of human brain and spinal cord samples, to investigate the involvement of TDP-43 in disease. Importantly, Dr Walker previously characterised new TDP-43 mice that develop both pathology and motor phenotypes reminiscent of human disease, which are a vital new tool for both investigations of disease mechanisms and pre-clinical testing of therapeutics.
Researcher biography
Dr Adam Walker received his BSc(Hons) in Biochemistry from the University of Tasmania, and PhD in Neuroscience from the Florey Institute of Neuroscience and Mental Health at the University of Melbourne, focused on understanding the molecular mechanisms of motor neuron disease (MND). He undertook a postdoctoral fellowship with Professor Virginia Lee at the Center for Neurodegenerative Disease Research, University of Pennsylvania (2011-2015), developing new transgenic TDP-43 mouse models of disease. Dr Walker was previously an NHMRC CJ Martin Overseas Biomedical Research Fellow and was awarded an NHMRC RD Wright Career Development Fellowship (2018-2022), to continue his research on neurodegenerative diseases.
He was Group Leader in the Clem Jones Centre for Ageing Dementia Research at the Queensland Brain Institute 2018-2025, and is now Honorary Professor.
Book Chapters
Wu, Jemma X., Pascovici, Dana, Wu, Yunqi, Walker, Adam K. and Mirzaei, Mehdi (2023). Application of WGCNA and PloGO2 in the analysis of complex proteomic data. Statistical analysis of proteomic data: methods and tools. (pp. 375-390) edited by Thomas Burger. New York, NY, United States: Humana Press. doi: 10.1007/978-1-0716-1967-4_17
Walker, A. K., Turner, B. J. and Atkin, J. D. (2009). Endoplasmic reticulum stress and protein misfolding in amyotrophic lateral sclerosis. Protein Misfolding Disorders: A Trip into the ER. (pp. 56-76) edited by K. Walker, A., J. Turner, B. and D. Atkin, J.. Bentham Science Publishers Ltd.. doi: 10.2174/978160805013010901010056
Journal Articles
Fowler, Megan, Carr, Jillian M, Gold, Julian, Walker, Adam and Rogers, Mary-Louise (2026). Evaluation of triumeq treatment on a TDP-43 mouse model of amyotrophic Lateral sclerosis. Scientific Reports. doi: 10.1038/s41598-026-55433-9
Lewis, Katherine N., Craig, Georgina A., Mason, Joel, Tomas, Doris, Cuic, Brittany, Walker, Adam K., Gonsalvez, David G., Turner, Bradley J. and Barton, Samantha K. (2026). Oligodendroglial densities and myelin structure are altered in TDP-43 related amyotrophic lateral sclerosis. Glia, 74 (1) e70090, 1-12. doi: 10.1002/glia.70090
Luan, Wei, San Gil, Rebecca, Madrid San Martin, Lidia, Cao, Maize C., Vassallu, Florencia, Venturato, Juliana, West, Phillip K., Brown-Wright, Heledd, Bademosi, Adekunle T., Chye, Yi Jia, Wu, Hao Yu, Harutyunyan, Anna, Robinson, Katherine J., Chang, Mu Sheen, Blizzard, Catherine A., Scotter, Emma L., Igaz, Lionel M. and Walker, Adam K. (2025). Synaptic changes contribute to persistent extra-motor behaviour deficits in amyotrophic lateral sclerosis. Acta Neuropathologica Communications, 14 (1) 26. doi: 10.1186/s40478-025-02150-5
Swanson, Molly E. V., Mrkela, Miran, Turner, Clinton, Curtis, Maurice A., Faull, Richard L. M., Walker, Adam K. and Scotter, Emma L. (2025). Neuronal TDP-43 aggregation drives changes in microglial morphology prior to immunophenotype in amyotrophic lateral sclerosis. Acta Neuropathologica Communications, 13 (1) 39, 1-16. doi: 10.1186/s40478-025-01941-0
Risby-Jones, Grace, Marallag, Jianina, Jagaraj, Cyril Jones, Atkin, Julie D., Walker, Adam K., Woodruff, Trent M., Lee, John D. and Fung, Jenny N. (2025). IL-6 trans-signalling is elevated in ALS models and drives TDP-43 induced inflammatory responses in microglia. Brain, Behavior, and Immunity, 129, 296-304. doi: 10.1016/j.bbi.2025.06.021
Flores, Brittany N., Yu, Seungyoon B., Cohen, Isaac V., Fanok, Melania H., Luan, Wei, Maciuca, Romeo D., Sun, Linus D., Tsai, Richard M., Vissers, Maurits, Smits, Lars, Bunte, Tommy M., Bakardjiev, Anna, Balasundar, Srijana, Calvert, Meredith E. K., Chin, Marcus Y., Dobbins, Sarah K., Dowdle, William E., Fang, Meng, Heuberger, Jules A. A. C., Ha, Connie L., Huang, Fen, Miyamoto, Takashi, Osipov, Maksim, Madrid San Martin, Lidia, Saund, Katie, Tatarakis, David, Vu, Anthony Q., Xiong, Chenling, Yeo, Gene W. ... Lewcock, Joseph W. (2025). Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial. Nature Communications, 16 (1) 7690, 1-23. doi: 10.1038/s41467-025-63031-y
Kellett, Elise A., Bademosi, Adekunle T. and Walker, Adam K. (2025). Molecular mechanisms and consequences of TDP-43 phosphorylation in neurodegeneration. Molecular Neurodegeneration, 20 (1) 53, 1-35. doi: 10.1186/s13024-025-00839-8
Cheng, Flora, Chapman, Tyler, Venturato, Juliana, Davidson, Jennilee M., Polido, Stella A., Rosa‐Fernandes, Livia, San Gil, Rebecca, Suddull, Hannah J., Zhang, Selina, Macaslam, Chiara Y., Szwaja, Paulina, Chung, Roger, Walker, Adam K., Rayner, Stephanie L., Morsch, Marco and Lee, Albert (2025). Proteomics analysis of the TDP‐43 interactome in cellular models of ALS pathogenesis. Journal of Neurochemistry, 169 (5) e70079, 1-21. doi: 10.1111/jnc.70079
San Gil, Rebecca and Walker, Adam K. (2025). Unlocking disease‐modifying treatments for TDP‐43‐mediated neurodegeneration. BioEssays, 47 (4) e202400257, 1-9. doi: 10.1002/bies.202400257
Zamani, Akram, Walker, Adam K. and Wright, David K. (2025). Glymphatic dysfunction and neurodegeneration in ALS: Longitudinal insights from rNLS8 TDP-43 mice. Neurobiology of Disease, 206 106832, 1-10. doi: 10.1016/j.nbd.2025.106832
Tsitkanou, Stavroula, Lindsay, Angus, Abbott, Gavin, Foletta, Victoria, Walker, Adam K., Russell, Aaron P. and Della Gatta, Paul A. (2024). Exercise training induces mild skeletal muscle adaptations without altering disease progression in a TDP-43 mouse model. Journal of Applied Physiology, 137 (3), 728-745. doi: 10.1152/japplphysiol.00192.2023
Jacobs, Swen, Perez, Guillermo A., Abraham, Remco, Bruyere, Veronique, Cadilhac, Michael, Colange, Maximilien, Delfosse, Charly, van Dijk, Tom, Duret-Lutz, Alexandre, Faymonville, Peter, Finkbeiner, Bernd, Khalimov, Ayrat, Klein, Felix, Luttenberger, Michael, Meyer, Klara, Michaud, Thibaud, Pommellet, Adrien, Renkin, Florian, Schlehuber-Caissier, Philipp, Sakr, Mouhammad, Sickert, Salomon, Staquet, Gaetan, Tamines, Clement, Tentrup, Leander and Walker, Adam (2024). The Reactive Synthesis Competition (SYNTCOMP): 2018-2021. International Journal On Software Tools for Technology Transfer, 26 (5), 551-567. doi: 10.1007/s10009-024-00754-1
San Gil, Rebecca, Pascovici, Dana, Venturato, Juliana, Brown-Wright, Heledd, Mehta, Prachi, Madrid San Martin, Lidia, Wu, Jemma, Luan, Wei, Chui, Yi Kit, Bademosi, Adekunle T., Swaminathan, Shilpa, Naidoo, Serey, Berning, Britt A., Wright, Amanda L., Keating, Sean S., Curtis, Maurice A., Faull, Richard L. M., Lee, John D., Ngo, Shyuan T., Lee, Albert, Morsch, Marco, Chung, Roger S., Scotter, Emma, Lisowski, Leszek, Mirzaei, Mehdi and Walker, Adam K. (2024). A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration. Nature Communications, 15 (1) 1508, 1508. doi: 10.1038/s41467-024-45646-9
Jacobs, Matisse T., San Gil, Rebecca and Walker, Adam K. (2023). UndERACting ion channels in neurodegeneration. Trends in Neurosciences, 47 (2), 87-89. doi: 10.1016/j.tins.2023.11.002
Swanson, Molly E.V., Mrkela, Miran, Murray, Helen C., Cao, Maize C., Turner, Clinton, Curtis, Maurice A., Faull, Richard L.M., Walker, Adam K. and Scotter, Emma L. (2023). Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain. Acta Neuropathologica Communications, 11 (1) 69, 1-22. doi: 10.1186/s40478-023-01561-6
Luan, Wei, Wright, Amanda L., Brown-Wright, Heledd, Le, Sheng, San Gil, Rebecca, Madrid San Martin, Lidia, Ling, Karen, Jafar-Nejad, Paymaan, Rigo, Frank and Walker, Adam K. (2023). Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTD. Molecular Psychiatry, 28 (6), 2445-2461. doi: 10.1038/s41380-023-02036-9
Keating, Sean S., Bademosi, Adekunle T., San Gil, Rebecca and Walker, Adam K. (2023). Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43. Cellular and Molecular Life Sciences, 80 (4) 95, 1-23. doi: 10.1007/s00018-023-04739-2
Bademosi, Adekunle T. and Walker, Adam K. (2022). Cryptic inclusions UNCover losses driving neurodegeneration. Trends in Genetics, 38 (9), 889-891. doi: 10.1016/j.tig.2022.06.004
Keating, Sean S., San Gil, Rebecca, Swanson, Molly E.V., Scotter, Emma L. and Walker, Adam K. (2022). TDP-43 pathology: from noxious assembly to therapeutic removal. Progress in Neurobiology, 211 102229, 102229. doi: 10.1016/j.pneurobio.2022.102229
Zamani, Akram, Walker, Adam K., Rollo, Ben, Ayers, Katie L., Farah, Raysha, O’Brien, Terence J. and Wright, David K. (2022). Impaired glymphatic function in the early stages of disease in a TDP-43 mouse model of amyotrophic lateral sclerosis. Translational Neurodegeneration, 11 (1) 17, 1-11. doi: 10.1186/s40035-022-00291-4
Zamani, Akram, Walker, Adam K., Rollo, Ben, Ayers, Katie L., Farah, Raysha, O'Brien, Terence J. and Wright, David K. (2022). Early and progressive dysfunction revealed by in vivo neurite imaging in the rNLS8 TDP-43 mouse model of ALS. NeuroImage: Clinical, 34 103016, 103016. doi: 10.1016/j.nicl.2022.103016
Tsitkanou, Stavroula, Della Gatta, Paul A., Abbott, Gavin, Wallace, Marita A., Lindsay, Angus, Gerlinger-Romero, Frederico, Walker, Adam K., Foletta, Victoria C. and Russell, Aaron P. (2022). miR-23a suppression accelerates functional decline in the rNLS8 mouse model of TDP-43 proteinopathy. Neurobiology of Disease, 162 105559, 105559. doi: 10.1016/j.nbd.2021.105559
Dyer, Marcus S., Reale, Laura A., Lewis, Katherine E., Walker, Adam K., Dickson, Tracey C., Woodhouse, Adele and Blizzard, Catherine A. (2021). Mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex (vol 157, pg 1300, 2020). Journal of Neurochemistry, 159 (4), 789-790. doi: 10.1111/jnc.15494
Wright, Amanda L., Della Gatta, Paul A., Le, Sheng, Berning, Britt A., Mehta, Prachi, Jacobs, Kelly R., Gul, Hossai, San Gil, Rebecca, Hedl, Thomas J., Riddell, Winonah R., Watson, Owen, Keating, Sean S., Venturato, Juliana, Chung, Roger S., Atkin, Julie D., Lee, Albert, Shi, Bingyang, Blizzard, Catherine A., Morsch, Marco and Walker, Adam K. (2021). Riluzole does not ameliorate disease caused by cytoplasmic TDP‐43 in a mouse model of amyotrophic lateral sclerosis. European Journal of Neuroscience, 54 (6) ejn.15422, 6237-6255. doi: 10.1111/ejn.15422
Dyer, Marcus S., Reale, Laura A., Lewis, Katherine E., Walker, Adam K., Dickson, Tracey C., Woodhouse, Adele and Blizzard, Catherine A. (2021). Mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex. Journal of Neurochemistry, 157 (4), 1300-1315. doi: 10.1111/jnc.15214
Cheng, Flora, De Luca, Alana, Hogan, Alison L., Rayner, Stephanie L., Davidson, Jennilee M., Watchon, Maxinne, Stevens, Claire H., Muñoz, Sonia Sanz, Ooi, Lezanne, Yerbury, Justin J., Don, Emily K., Fifita, Jennifer A., Villalva, Maria D., Suddull, Hannah, Chapman, Tyler R., Hedl, Thomas J., Walker, Adam K., Yang, Shu, Morsch, Marco, Shi, Bingyang, Blair, Ian P., Laird, Angela S., Chung, Roger S. and Lee, Albert (2021). Unbiased label-free quantitative proteomics of cells expressing Amyotrophic Lateral Sclerosis (ALS) mutations in CCNF reveals activation of the apoptosis pathway: a workflow to screen pathogenic gene mutations. Frontiers in Molecular Neuroscience, 14 627740, 1-18. doi: 10.3389/fnmol.2021.627740
Berga, Laura, Bruce, Isobel, Nicol, Thomas W. J., Holding, Ashley J., Isobe, Noriyuki, Shimizu, Seishi, Walker, Adam J. and Reid, Joshua E. S. J. (2020). Cellulose dissolution and regeneration using a non-aqueous, non-stoichiometric protic ionic liquid system. Cellulose, 27 (16), 9593-9603. doi: 10.1007/s10570-020-03444-8
Konopka, Anna, Whelan, Donna R., Jamali, Md Shafi, Perri, Emma, Shahheydari, Hamideh, Toth, Reka P., Parakh, Sonam, Robinson, Tina, Cheong, Alison, Mehta, Prachi, Vidal, Marta, Ragagnin, Audrey M G, Khizhnyak, Ivan, Jagaraj, Cyril J., Galper, Jasmin, Grima, Natalie, Deva, Anand, Shadfar, Sina, Nicholson, Garth A., Yang, Shu, Cutts, Suzanne M., Horejsi, Zuzana, Bell, Toby D M, Walker, Adam K., Blair, Ian P. and Atkin, Julie D. (2020). Impaired NHEJ repair in amyotrophic lateral sclerosis is associated with TDP-43 mutations. Molecular neurodegeneration, 15 (1) 51, 51. doi: 10.1186/s13024-020-00386-4
Gil, R. San, Cox, D., McAlary, L., Berg, T., Walker, A. K., Yerbury, J. J., Ooi, L. and Ecroyd, H. (2020). Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal cells. Journal of Cell Science, 133 (15) jcs243709, 1-15. doi: 10.1242/jcs.243709
Wu, Jemma X., Pascovici, Dana, Wu, Yunqi, Walker, Adam K. and Mirzaei, Mehdi (2020). Workflow for rapidly extracting biological insights from complex, multicondition proteomics experiments with WGCNA and PloGO2. Journal of Proteome Research, 19 (7), 2898-2906. doi: 10.1021/acs.jproteome.0c00198
Perri, Emma R., Parakh, Sonam, Vidal, Marta, Mehta, Prachi, Ma, Yi, Walker, Adam K. and Atkin, Julie D. (2020). Correction: The cysteine (Cys) residues Cys-6 and Cys-111 in mutant superoxide dismutase 1 (SOD1) A4V are required for induction of endoplasmic reticulum stress in amyotrophic lateral sclerosis. Journal of Molecular Neuroscience, 70 (9), 1369-1369. doi: 10.1007/s12031-020-01617-5
Perri, Emma R., Parakh, Sonam, Vidal, Marta, Mehta, Prachi, Ma, Yi, Walker, Adam K. and Atkin, Julie D. (2020). The cysteine (Cys) residues Cys-6 and Cys-111 in mutant superoxide dismutase 1 (SOD1) A4V are required for induction of endoplasmic reticulum stress in amyotrophic lateral sclerosis. Journal of Molecular Neuroscience, 70 (9), 1357-1368. doi: 10.1007/s12031-020-01551-6
Hedl, Thomas J., San Gil, Rebecca, Cheng, Flora, Rayner, Stephanie L., Davidson, Jennilee M., De Luca, Alana, Villalva, Maria D., Ecroyd, Heath, Walker, Adam K. and Lee, Albert (2019). Proteomics approaches for biomarker and drug target discovery in ALS and FTD. Frontiers in Neuroscience, 13 (JUN) 548, 548. doi: 10.3389/fnins.2019.00548
Wang, Guoying, Fu, Libing, Walker, Adam, Chen, Xianfeng, Lovejoy, David B., Hao, Mingcong, Lee, Albert, Chung, Roger, Rizos, Helen, Irvine, Mal, Zheng, Meng, Liu, Xiuhua, Lu, Yiqing and Shi, Bingyang (2019). Label-free fluorescent poly(amidoamine) dendrimer for traceable and controlled drug delivery. Biomacromolecules, 20 (5), 2148-2158. doi: 10.1021/acs.biomac.9b00494
Berning, Britt A. and Walker, Adam K. (2019). The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD. Frontiers in Neuroscience, 13 (APR) 335, 335. doi: 10.3389/fnins.2019.00335
McCann, Emily P., Fifita, Jennifer A., Grima, Natalie, Galper, Jasmin, Mehta, Prachi, Freckleton, Sarah E., Zhang, Katharine Y., Henden, Lyndal, Hogan, Alison L., Chan Moi Fat, Sandrine, Wu, Sharlynn S.L., Jagaraj, Cyril J., Berning, Britt A., Williams, Kelly Louise, Twine, Natalie A., Bauer, Denis, Piguet, Olivier, Hodges, John, Kwok, John B.J., Halliday, Glenda M., Kiernan, Matthew C., Atkin, Julie, Rowe, Dominic B., Nicholson, Garth A., Walker, Adam K., Blair, Ian P. and Yang, Shu (2019). Genetic and immunopathological analysis of CHCHD10 in Australian amyotrophic lateral sclerosis and frontotemporal dementia and transgenic TDP-43 mice. Journal of Neurology, Neurosurgery and Psychiatry, 91 (2), 162-2019. doi: 10.1136/jnnp-2019-321790
Wu, Yantong, Li, Shasha, Liu, Jinjin, Liu, Xiping, Ruan, Weimin, Lu, Jengwei, Liu, Yong, Lawson, Tom, Shimoni, Olga, Lovejoy, David B., Walker, Adam K., Cong, Yue and Shi, Bingyang (2018). Stilbenes from Veratrum maackii Regel protect against ethanol-induced DNA damage in mouse cerebellum and cerebral cortex. ACS Chemical Neuroscience, 9 (7), 1616-1624. doi: 10.1021/acschemneuro.8b00006
Parakh, Sonam, Jagaraj, Cyril J., Vidal, Marta, Ragagnin, Audrey M. G., Perri, Emma R., Konopka, Anna, Toth, Reka P., Galper, Jasmin, Blair, Ian P., Thomas, Colleen J., Walker, Adam K., Yang, Shu, Spencer, Damian M. and Atkin, Julie D. (2018). ERp57 is protective against mutant SOD1-induced cellular pathology in amyotrophic lateral sclerosis. Human Molecular Genetics, 27 (8), 1311-1331. doi: 10.1093/hmg/ddy041
Farg, Manal A., Soo, Kai Y., Walker, Adam K., Pham, Hong, Orian, Jacqueline, Horne, Malcolm K., Warraich, Sadaf T., Williams, Kelly L., Blair, Ian P. and Atkin, Julie D. (2017). Note in reference to “Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase” [Neurobiol. Aging 33(12) (2012) 2855-2868]. Neurobiology of Aging, 60, 205-205. doi: 10.1016/j.neurobiolaging.2017.10.001
Reid, Joshua E. S. J., Bernardes, Carlos E. S., Agapito, Filipe, Martins, Filomena, Shimizu, Seishi, Minas da Piedade, Manuel E. and Walker, Adam J. (2017). Structure-property relationships in protic ionic liquids: a study of solvent-solvent and solvent-solute interactions. Physical Chemistry Chemical Physics, 19 (41), 28133-28138. doi: 10.1039/c7cp05076c
Lee, Albert, Rayner, Stephanie L., De Luca, Alana, Gwee, Serene S. L., Morsch, Marco, Sundaramoorthy, Vinod, Shahheydari, Hamideh, Ragagnin, Audrey, Shi, Bingyang, Yang, Shu, Williams, Kelly L., Don, Emily K., Walker, Adam K., Zhang, Katharine Y., Yerbury, Justin J., Cole, Nicholas J., Atkin, Julie D., Blair, Ian P., Molloy, Mark P. and Chung, Roger S. (2017). Casein kinase II phosphorylation of cyclin F at serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(cyclin F) complex. Open Biology, 7 (10) 170058, 170058. doi: 10.1098/rsob.170058
Sundaramoorthy, Vinod, Walker, Adam K., Tan, Vanessa, Fifita, Jennifer A., Mccann, Emily P., Williams, Kelly L., Blair, Ian P., Guillemin, Gilles J., Farg, Manal A. and Atkin, Julie D. (2017). Erratum: Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis (Human molecular genetics (2015) 24 13 (3830-3846)). Human Molecular Genetics, 26 (17), 3452-3452. doi: 10.1093/hmg/ddx268
Lee, Albert, Rayner, Stephanie L., Gwee, Serene S. L., De Luca, Alana, Shahheydari, Hamideh, Sundaramoorthy, Vinod, Ragagnin, Audrey, Morsch, Marco, Radford, Rowan, Galper, Jasmin, Freckleton, Sarah, Shi, Bingyang, Walker, Adam K., Don, Emily K., Cole, Nicholas J., Yang, Shu, Williams, Kelly L., Yerbury, Justin J., Blair, Ian P., Atkin, Julie D., Molloy, Mark P. and Chung, Roger S. (2017). Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy. Cellular and Molecular Life Sciences, 75 (2), 335-354. doi: 10.1007/s00018-017-2632-8
Jacobs, Swen, Bloem, Roderick, Brenguier, Romain, Ehlers, Ruediger, Hell, Timotheus, Koenighofer, Robert, Perez, Guillermo A., Raskin, Jean-Francois, Ryzhyk, Leonid, Sankur, Ocan, Seidl, Martina, Tentrup, Leander and Walker, Adam (2017). The first reactive synthesis competition (SYNTCOMP 2014). International Journal On Software Tools for Technology Transfer, 19 (3), 367-390. doi: 10.1007/s10009-016-0416-3
Shahheydari, Hamideh, Ragagnin, Audrey, Walker, Adam K., Toth, Reka P., Vidal, Marta, Jagaraj, Cyril J., Perri, Emma R., Konopka, Anna, Sultana, Jessica M. and Atkin, Julie D. (2017). Protein quality control and the amyotrophic lateral sclerosis/frontotemporal dementia continuum. Frontiers in Molecular Neuroscience, 10 119, 1-25. doi: 10.3389/fnmol.2017.00119
Walker, Adam K., Tripathy, Kalyan, Restrepo, Clark R., Ge, Guanghui, Xu, Yan, Kwong, Linda K., Trojanowski, John Q. and Lee, Virginia M. -Y. (2015). An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice. Human Molecular Genetics, 24 (25), 7241-7254. doi: 10.1093/hmg/ddv424
Walker, Adam K., Spiller, Krista J., Ge, Guanghui, Zheng, Allen, Xu, Yan, Zhou, Melissa, Tripathy, Kalyan, Kwong, Linda K., Trojanowski, John Q. and Lee, Virginia M. -Y. (2015). Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43. Acta Neuropathologica, 130 (5), 643-660. doi: 10.1007/s00401-015-1460-x
Sundaramoorthy, Vinod, Walker, Adam K., Tan, Vanessa, Fifita, Jennifer A., Mccann, Emily P., Williams, Kelly L., Blair, Ian P., Guillemin, Gilles J., Farg, Manal A. and Atkin, Julie D. (2015). Defects in optineurin- and myosin VI-mediated cellular trafficking in amyotrophic lateral sclerosis. Human Molecular Genetics, 24 (13), 3830-3846. doi: 10.1093/hmg/ddv126
Jamasbi, Janina, Megens, Remco T. A., Bianchini, Mariaelvy, Muench, Goetz, Ungerer, Martin, Faussner, Alexander, Sherman, Shachar, Walker, Adam, Goyal, Pankaj, Jung, Stephanie, Brandl, Richard, Weber, Christian, Lorenz, Reinhard, Farndale, Richard, Elia, Natalie and Siess, Wolfgang (2015). Differential Inhibition of Human Atherosclerotic Plaque-Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies Functional and Imaging Studies. Journal of the American College of Cardiology, 65 (22), 2404-2415. doi: 10.1016/j.jacc.2015.03.573
Walker, Adam K., Daniels, Christine M. LaPash, Goldman, James E., Trojanowski, John Q., Lee, Virginia M. -Y. and Messing, Albee (2014). Astrocytic TDP-43 pathology in Alexander disease. Journal of Neuroscience, 34 (19), 6448-6458. doi: 10.1523/JNEUROSCI.0248-14.2014
Atkin, Julie D., Farg, Manal A., Soo, Kai Ying, Walker, Adam K., Halloran, Mark, Turner, Bradley J., Nagley, Phillip and Horne, Malcolm K. (2014). Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis. Journal of Neurochemistry, 129 (1), 190-204. doi: 10.1111/jnc.12493
Kwong, Linda K., Irwin, David J., Walker, Adam K., Xu, Yan, Riddle, Dawn M, Trojanowski, John Q. and Lee, Virginia M. Y. (2014). Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins. Acta Neuropathologica Communications, 2 (1) 33. doi: 10.1186/2051-5960-2-33
Walker, Adam K., Soo, Kai Y., Sundaramoorthy, Vinod, Parakh, Sonam, Ma, Yi, Farg, Manal A., Wallace, Robyn H., Crouch, Peter J., Turner, Bradley J., Horne, Malcolm K. and Atkin, Julie D. (2013). ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation. PLoS One, 8 (11) e81170, e81170.1-e81170.12. doi: 10.1371/journal.pone.0081170
Sundaramoorthy, Vinod, Walker, Adam K., Yerbury, Justin, Soo, Kai Ying, Farg, Manal A., Hoang, Vy, Zeineddine, Rafaa, Spencer, Damian and Atkin, Julie D. (2013). Extracellular wildtype and mutant SOD1 induces ER-Golgi pathology characteristic of amyotrophic lateral sclerosis in neuronal cells. Cellular and Molecular Life Sciences, 70 (21), 4181-4195. doi: 10.1007/s00018-013-1385-2
Walker, Adam K., Soo, Kai Ying, Levina, Vita, Talbo, Gert H. and Atkin, Julie D. (2013). N-linked glycosylation modulates dimerization of protein disulfide isomerase family A member 2 (PDIA2). FEBS Journal, 280 (1), 233-243. doi: 10.1111/febs.12063
Farg, Manal A., Soo, Kai Y., Walker, Adam K., Pham, Hong, Orian, Jacqueline, Horne, Malcolm K., Warraich, Sadaf T., Williams, Kelly L., Blair, Ian P. and Atkin, Julie D. (2012). Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase. Neurobiology of Aging, 33 (12), 2855-2868. doi: 10.1016/j.neurobiolaging.2012.02.009
Soo, Kai Y., Atkin, Julie D., Farg, Manal, Walker, Adam K., Horne, Malcolm K. and Nagley, Phillip (2012). Bim links ER stress and apoptosis in cells expressing mutant SOD1 associated with amyotrophic lateral sclerosis. PLoS One, 7 (4) e35413, e35413. doi: 10.1371/journal.pone.0035413
Walker, Adam K. and Atkin, Julie D. (2011). Stress signaling from the endoplasmic reticulum: a central player in the pathogenesis of amyotrophic lateral sclerosis. IUBMB Life, 63 (9), 754-763. doi: 10.1002/iub.520
Walker, Adam K. and Atkin, Julie D. (2011). Mechanisms of neuroprotection by protein disulphide isomerase in amyotrophic lateral sclerosis. Neurology Research International, 2011 317340. doi: 10.1155/2011/317340
Lovell, Christopher S., Walker, Adam, Damion, Robin A., Radhi, Asanah, Tanner, Steven F., Budtova, Tatiana and Ries, Michael E. (2010). Influence of Cellulose on Ion Diffusivity in 1-Ethyl-3-Methyl-Imidazolium Acetate Cellulose Solutions. Biomacromolecules, 11 (11), 2927-2935. doi: 10.1021/bm1006807
Walker, Adam, Dunlevy, Grainne, Rycroft, Daniel, Topley, Peter, Holt, Lucy J., Herbert, Tom, Davies, Marie, Cook, Fiona, Holmes, Steve, Jespers, Laurent and Herring, Chris (2010). Anti-serum albumin domain antibodies in the development of highly potent, efficacious and long-acting interferon. Protein Engineering Design & Selection, 23 (4), 271-278. doi: 10.1093/protein/gzp091
Walker, Adam K. (2010). Protein disulfide isomerase and the endoplasmic reticulum in amyotrophic lateral sclerosis. Journal of Neuroscience, 30 (11), 3865-3867. doi: 10.1523/JNEUROSCI.0408-10.2010
Walker, Adam K., Farg, Manal A., Bye, Chris R., McLean, Catriona A., Horne, Malcolm K. and Atkin, Julie D. (2010). Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis. Brain, 133 (1), 105-116. doi: 10.1093/brain/awp267
Jones, Chris I., Bray, Sarah, Garner, Stephen F., Stephens, Jonathan, de Bono, Bernard, Angenent, Will G. J., Bentley, David, Burns, Philippa, Coffey, Alison, Deloukas, Panos, Earthrowl, Mark, Farndale, Richard W., Hoylaerts, Marc F., Koch, Kerstin, Rankin, Angela, Rice, Catherine M., Rogers, Jane, Samani, Nilesh J., Steward, Michael, Walker, Adam, Watkins, Nicholas A., Akkerman, Jan-Willem, Dudbridge, Frank, Goodall, Alison H. and Ouwehand, Willem H. (2009). A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways. Blood, 114 (7), 1405-1416. doi: 10.1182/blood-2009-02-202614
Walker, Adam, Tanner, Matthew J., Husson, Paul, Schuler, Catherine, Kogan, Barry A., Buttyan, Ralph and Levin, Robert M. (2009). Differential Expression of Vascular Endothelial Growth Factor, and Angiopoietin 1 and 2 in Functionally Divergent Experimental Rabbit Models of Bladder Hypertrophy. Journal of Urology, 181 (6), 2790-2796. doi: 10.1016/j.juro.2009.01.100
O'Connor, Marie N., Salles, Isabelle I., Cvejic, Ana, Watkins, Nicholas A., Walker, Adam, Garner, Stephen F., Jones, Chris I., Macaulay, Iain C., Steward, Michael, Zwaginga, Jaap-Jan, Bray, Sarah L., Dudbridge, Frank, de Bono, Bernard, Goodall, Alison H., Deckmyn, Hans, Stemple, Derek L. and Ouwehand, Willem H. (2009). Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins. Blood, 113 (19), 4754-4762. doi: 10.1182/blood-2008-06-162693
Walker, Adam, Pugh, Nicholas, Garner, Stephen F., Stephens, Jonathan, Maddox, Ben, Ouwehand, Willem H., Farndale, Richard W. and Steward, Michael (2009). Single domain antibodies against the collagen signalling receptor glycoprotein VI are inhibitors of collagen induced thrombus formation. Platelets, 20 (4) PII 911474177, 268-276. doi: 10.1080/09537100902893792
Chung, Roger S., Penkowa, Milena, Dittmann, Justin, King, Carolyn E., Bartlett, Carole, Asmussen, Johanne W., Hidalgo, Juan, Carrasco, Javier, Leung, Yee Kee J., Walker, Adam K., Fung, Samantha J., Dunlop, Sarah A., Fitzgerald, Melinda, Beazley, Lyn D., Chuah, Meng I., Vickers, James C. and West, Adrian K. (2008). Redefining the role of metallothionein within the injured brain: Extracellular metallothioneins play an important role in the astrocyte-neuron response to injury. Journal of Biological Chemistry, 283 (22), 15349-15358. doi: 10.1074/jbc.M708446200
Chung, R. S., Fung, S. J., Leung, Y. K., Walker, A. K., McCormack, G. H., Chuah, M. I., Vickers, J. C. and West, A. K. (2007). Metallothionein expression by NG2 glial cells following CNS injury. Cellular and Molecular Life Sciences, 64 (19-20), 2716-2722. doi: 10.1007/s00018-007-7267-8
Conference Papers
Rode, Jennifer A., Feng, Yifan, Zhang, Hanlin, Rosman, Ria, Bastaman, Amanda S., King, John, Samson, Madeline H., Dong, Xinyue, Walker, Adam, Horton, Matthew, Read, Janet C., Oliver, Martin and Elmimouni, Houda (2024). Playful Telepresence Robots with School Children. 13th Nordic Conference on Human-Computer Interaction (NordiCHI), Uppsala Sweden, Oct 13-16, 2024. NEW YORK: ASSOC COMPUTING MACHINERY. doi: 10.1145/3679318.3685367
Merjane, Jessica, Brown-Wright, Heledd, Luu, Luan, Chung, Roger, Walker, Adam and Lisowski, Leszek (2023). Moving Past the BBB - Screening for the Most Functional CNS-Tropic AAV. 26th Annual Meeting of the American Society of Gene & Cell Therapy, Los Angeles, CA, United States, 16-20 May 2023. Cambridge, MA, United States: Cell Press. doi: 10.1016/j.ymthe.2023.04.017
Tye, Susannah, Price, J. Blair, Walker, Adam, Kruse, Jennifer, Cullen, Kathryn, Frye, Mark, Schwieler, Lilly and Erhardt, Sophie (2022). Inflammation Moderates Antidepressant Response to Ketamine in a Rodent Model of Treatment-Resistant Depression: Bioenergetic and Inflammatory Markers of Response. 61st Annual Meeting of the American-College-of-Neuropsychopharmacology (ACNP), Phoenix Az, Dec 04-07, 2022. LONDON: SPRINGERNATURE.
Dupati, Ajith, Qi, Ji, DiBianco, John M., Ferrante, Stephanie, Cole, Adam, Walker, Adam, Wei, John T., Ellimoottil, Chandy, Herrel, Lindsey A., Wu, Richard C., Stork, Brian R. and George, Arvin K. (2021). FREEHAND TRANSPERINEAL BIOPSY SAMPLING STRATEGIES: WHAT IS THE OPTIMAL TEMPLATE?. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
Dupati, Ajith, Qi, Ji, Ferrante, Stephanie, DiBianco, John M., Walker, Adam, Wei, John T., Ellimoottil, Chandy, Herrel, Lindsey A., Wu, Richard C., George, Arvin K. and Stork, Brian R. (2021). PROVIDER VARIATION IN PAIN SCORES DURING FREEHAND TRANSPERINEAL PROSTATE BIOPSY UNDER LOCAL ANESTHESIA. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
Ferrante, Stephanie, Hawken, Scott, Montie, James, Miller, David, Wu, Richard C., Ellimoottil, Chad, Herrel, Lindsey, Rogers, Craig, Patel, Amit, Frontera, J. Rene, Walker, Adam and George, Arvin (2020). PATIENT EXPERIENCE FOR TRANSPERINEAL BIOPSY UNDER LOCAL ANESTHESIA VERSUS TRANSRECTAL BIOPSY: RESULTS FROM THE MICHIGAN UROLOGICAL SURGERY IMPROVEMENT COLLABORATIVE. Annual Meeting of the American-Urological-Association (AUA), Washington Dc, May 15-18, 2020. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
Cole, Adam, Lee, Matthew, Raisky, Jeremy, Qi, Ji, Linsell, Susan, Martin, Rabia, Ellimoottil, Chandy, Walker, Adam, Stork, Brian, Herrel, Lindsey, Wei, John, Miller, David, Montie, Jim and George, Arvin (2019). MI TREXIT: PILOT EVALUATIONOFA STATE-WIDE INITIATIVE FOR IN-OFFICE TRANSPERINEAL VERSUS TRANSRECTAL PROSTATE BIOPSY UNDER LOCAL ANESTHESIA. 114th Annual Meeting of the American-Urological-Association (AUA), Chicago Il, May 03-06, 2019. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS.
Aleksic, Ilija, Sorokin, Igor, Aggarwal, Himanshu, Walker, Adam, Feustel, Paul and Kaufman, Ronald (2017). EARLY AMBULATION DECREASES HOSPITAL LENGTH OF STAY IN RENAL TRAUMA: A RANDOMIZED, PROSPECTIVE STUDY. Annual Meeting of the American-Urological-Association (AUA), Boston Ma, May 12-16, 2017. NEW YORK: ELSEVIER SCIENCE INC. doi: 10.1016/j.juro.2017.02.3314
Jacobs, Swen, Bloem, Roderick, Brenguier, Romain, Koenighofer, Robert, Perez, Guillermo A., Raskin, Jean-Francois, Ryzhyk, Leonid, Sankur, Ocan, Seidl, Martina, Tentrup, Leander and Walker, Adam (2016). The Second Reactive Synthesis Competition (SYNTCOMP 2015). 4th Workshop on Synthesis, San Francisco Ca, Jul 18, 2015. SYDNEY: OPEN PUBL ASSOC. doi: 10.4204/EPTCS.202.4
Ryzhyk, Leonid and Walker, Adam (2016). Developing a Practical Reactive Synthesis Tool: Experience and Lessons Learned. 5th Workshop on Synthesis (SYNT), Toronto Canada, Jul 17-18, 2016. SYDNEY: OPEN PUBL ASSOC. doi: 10.4204/EPTCS.229.8
Jacobs, Swen, Bloem, Roderick, Brenguier, Romain, Khalimov, Ayrat, Klein, Felix, Koenighofer, Robert, Kreber, Jens, Legg, Alexander, Narodytska, Nina, Perez, Guillermo A., Raskin, Jean-Francois, Ryzhyk, Leonid, Sankur, Ocan, Seidl, Martina, Tentrup, Leander and Walker, Adam (2016). The 3rd Reactive Synthesis Competition (SYNTCOMP 2016): Benchmarks, Participants & Results. 5th Workshop on Synthesis (SYNT), Toronto Canada, Jul 17-18, 2016. SYDNEY: OPEN PUBL ASSOC. doi: 10.4204/EPTCS.229.12
Narodytska, Nina, Legg, Alexander, Bacchus, Fahiem, Ryzhyk, Leonid and Walker, Adam (2014). Solving Games without Controllable Predecessor. 26th International Conference on Computer Aided Verification (CAV) Held as Part of the Vienna Summer of Logic (VSL), Vienna Austria, Jul 18-22, 2014. CHAM: SPRINGER INTERNATIONAL PUBLISHING AG.
Walker, Adam and Ryzhyk, Leonid (2014). Predicate Abstraction for Reactive Synthesis. Conference on Formal Methods in Computer-Aided Design (FMCAD), Lausanne Switzerland, Oct 21-24, 2014. NEW YORK: IEEE.
Sosabowski, Jane, Coulstock, Edward, Walker, Adam, Sepp, Armin, Kashani, Roxana, Foster, Julie, Burnet, Jerome, Prince, Rob, Kirk, Semra and Mather, Stephen (2011). Biodistribution and microSPECT/CT imaging of 111In-radiolabelled dual targeted domain antibodies. RESTON: SOC NUCLEAR MEDICINE INC.
Salles, Isabelle I., O'Connor, Marie N., Watkins, Nicholas A., Walker, Adam, Garner, Stephen F., Jones, Chris I., Macauley, Iain, Steward, Michael, Zwaginga, Jaap Jan, Bray, Sarah L., Cvejic, Ana, Dudbridge, Frank, de Bono, Bernard, Deckmyn, Hans, Stemple, Derek L. and Ouwehand, Willem (2008). Functional Genomics in Zebrafish Permits Rapid Characterization of Novel Platelet Membrane Proteins. 50th Annual Meeting of the American-Society-of-Hematology, San Francisco Ca, Dec 06-09, 2008. WASHINGTON: AMER SOC HEMATOLOGY.