Tye publications
Deep brain stimulation of the nucleus accumbens modulates effort-based decision-making and phasic dopamine release in male Wistar rats
McCullough, Sebastian, Varela, Roger B., Houghton, Tristan, Cruickshank, Heather, and Tye, Susannah J. (2026). Deep brain stimulation of the nucleus accumbens modulates effort-based decision-making and phasic dopamine release in male Wistar rats. Journal of Neurochemistry 170 (6) e70485 . https://doi.org/10.1111/jnc.70485
Leveraging expert and lived experience of mental ill health perspectives to traverse the research translational gap
Milton, Laura, McDonnell, Conor, Thivisol, Ulysse, Foldi, Claire, Kesby, James, Tye, Susannah, Cruickshank, Heather, Hedberg, Anette, Boyce, Niall, Hill, Rachel, and Sundram, Suresh (2026). Leveraging expert and lived experience of mental ill health perspectives to traverse the research translational gap. Society of Biological Psychiatry’s 2026 Annual Meeting, New York, United States, 30 April-2 May 2026. Philadelphia, PA, United States: Elsevier.https://doi.org/10.1016/j.biopsych.2026.03.823
220. An Online Library of Animal Models: Finding the Best Models and Assays for Depression, Anxiety, and Psychosis
Donnell, Conor Mc, Milton, Laura, Thivisol, Ulysse, Foldi, Claire, Kesby, James, Tye, Susannah, Boyce, Niall, Hill, Rachel, and Sundram, Suresh (2026). 220. An Online Library of Animal Models: Finding the Best Models and Assays for Depression, Anxiety, and Psychosis. Biological Psychiatry 99 (10) S193. https://doi.org/10.1016/j.biopsych.2026.03.454
198. Plasma Lactate as a Metabolic Predictor of Ketamine Response in Treatment-Resistant Depression
Scaini, Giselli, Pinheiro Gusmao, Camilla Teixeira, Carbajal Tamez, Marcela C., Cordeiro, Rafaela C., de Quevedo, Joao, Tye, Susannah, Elmallakh, Rifaat, Parikh, Sagar, Bobo, William, Goes, Fernando S., Vande Voort, Jennifer L., Nykamp, Louis, Balwinder, Singh, Nelson, Erik, Thase, Michael, Frye, Mark, Greden, John, and Achtyes, Eric (2026). 198. Plasma Lactate as a Metabolic Predictor of Ketamine Response in Treatment-Resistant Depression. Biological Psychiatry 99 (10) S183-S184. https://doi.org/10.1016/j.biopsych.2026.03.432
Melatonin in bipolar disorder
Macpherson, Heather K., Varela, Roger B., Truong, Trang T. T., Walder, Ken, Berk, Michael, and Tye, Susannah J. (2026). Melatonin in bipolar disorder. Journal of Affective Disorders 398 120871 1-24. https://doi.org/10.1016/j.jad.2025.120871
ATP bioenergetics and fatigue in young adults with and without major depression
Cullen, Kathryn R., Tye, Susannah J., Klimes-Dougan, Bonnie, Wiesner, Hannes M., Varela, Roger B., Morath, Brooke, Zhang, Lin, Chen, Wei, and Zhu, Xiao-Hong (2026). ATP bioenergetics and fatigue in young adults with and without major depression. Translational Psychiatry 16 (1) 158 . https://doi.org/10.1038/s41398-026-03904-y
Of mice, molecules and mental health: establishment of the consortium for preclinical psychiatric research to find solutions to the translational gap
Consortium for Preclinical Psychiatric Research, Hill, Rachel A., Bastawy, Eslam M., Berk, Michael, Brown, Robyn M., Burne, Thomas H., Chesworth, Rose, Clark, Scott R., Clemens, Kelly J., Cui, Xiaoying, Dunn, Ariel L., Eratne, Dhamidhu, Foldi, Claire J., Gatt, Justine M., Gubert, Carolina, Gurvich, Caroline, Hannan, Anthony J., Harms, Lauren, Hill-Yardin, Elisa L., Jaehne, Emily J., Jawahar, Magdalene C., Jones, Nigel C., Kang, Matthew JY, Karl, Tim, Kesby, James P., Kim, Jee Hyun, Lawrence, Andrew J., Cruickshank, Heather, Manning, Elizabeth E. and 17 more (2026). Of mice, molecules and mental health: establishment of the consortium for preclinical psychiatric research to find solutions to the translational gap. Molecular Psychiatry 31 (2) 1167-1170. https://doi.org/10.1038/s41380-025-03361-x
Unlocking clinical mechanisms through animal models: a Wellcome Initiative
Tye, Susannah, Mayberg, Helen, Sundram, Suresh, Hill, Rachel, Erhardt, Sophie, Ahmari, Susanne, and Young, Jared (2026). Unlocking clinical mechanisms through animal models: a Wellcome Initiative. 64th Annual Meeting of the American-College-of-Neuropsychopharmacology (ACNP), Nassau, Bahamas, 12-15 January 2026. London, United Kingdom: Nature Publishing Group.https://doi.org/10.1038/s41386-025-02278-x
Novel psychedelic interventions for post-traumatic stress disorder and their promise for precision medicine
Dodds, Charles, Dawson, Rachelle, Lim, Alexander, Tye, Susannah, and Nasrallah, Fatima (2025). Novel psychedelic interventions for post-traumatic stress disorder and their promise for precision medicine. Therapeutic Advances in Psychopharmacology 15 20451253251396255 1-25. https://doi.org/10.1177/20451253251396255
Fueling the future: brain bioenergetics as a driver of neurodevelopment and mental health trajectories
Tye, Susannah J. and Cullen, Kathryn R. (2025). Fueling the future: brain bioenergetics as a driver of neurodevelopment and mental health trajectories. Neuropsychopharmacology 51 (1) 334-336. https://doi.org/10.1038/s41386-025-02230-z
Unpredictable circadian rhythm disruption in Wistar rats: biological and behavioural changes reflecting bipolar disorder pathophysiology
MacPherson, Heather, Varela, Roger B., McCullough, Sebastian C., Houghton, Tristan, Chawla, Isha, Wang, Ning, Daygon, Venea Dara, Cui, Xiaoying, and Tye, Susannah J. (2025). Unpredictable circadian rhythm disruption in Wistar rats: biological and behavioural changes reflecting bipolar disorder pathophysiology.https://doi.org/10.1101/2025.09.06.674601
Melatonin mitigates oxidative stress and metabolic dysfunction induced by interleukin-6 and dopamine in SH-SY5Y cells
MacPherson, Heather, Varela, Roger B., Daygon, Venea Dara, Kesby, James P., Cui, Xiaoying, and Tye, Susannah J. (2025). Melatonin mitigates oxidative stress and metabolic dysfunction induced by interleukin-6 and dopamine in SH-SY5Y cells.https://doi.org/10.1101/2025.09.03.673920
Investigating the role of melatonin in bipolar disorder using transcriptomics
MacPherson, Heather, Truong, Trang T. T., Berk, Michael, Walder, Ken, and Tye, Susannah J. (2025). Investigating the role of melatonin in bipolar disorder using transcriptomics.https://doi.org/10.1101/2025.09.03.673928
Immunometabolic dysfunction and dopaminergic impairment in an animal model of treatment-resistant anhedonia: implications for bipolar disorder
Varela, Roger, Macpherson, Heather, Houghton, Tristan, Yates, Clarissa, Yates, Nathanael, Daygon, Dara, and Tye, Susannah (2025). Immunometabolic dysfunction and dopaminergic impairment in an animal model of treatment-resistant anhedonia: implications for bipolar disorder. The 27th Annual Conference of the International Society for Bipolar Disorders, Chiba, Japan, 17 – 19 September 2025. Hoboken, NJ, United States: Wiley-Blackwell Publishing.
Bioenergetic Dysregulation in Peripheral Immune Cells: Links to Anhedonia and Fatigue in Depressed Young Adults
Varela, Roger, Cullen, Kathryn, Morath, Brooke, and Tye, Susannah (2025). Bioenergetic Dysregulation in Peripheral Immune Cells: Links to Anhedonia and Fatigue in Depressed Young Adults. The 27th Annual Conference of the International Society for Bipolar Disorders, Chiba, Japan, 17 – 19 September 2025. Hoboken, NJ, United States: Wiley-Blackwell Publishing.
Unpredictable Circadian Disturbance Induces Bipolar-Like Behavioural and Immunometabolic Dysregulation in Rats
Macpherson, Heather, Varela, Roger, McCullough, Sebastian, Houghton, Tristan, Chawla, Isha, Wang, Ning, Daygon, Venea, Cui, Xiaoying, and Tye, Susannah (2025). Unpredictable Circadian Disturbance Induces Bipolar-Like Behavioural and Immunometabolic Dysregulation in Rats. 27th Annual Conference of the International Society for Bipolar Disorders, Chiba, Japan, 17-19 September 2025. Hoboken, NJ, United States: Wiley-Blackwell.
Exploring the Role of Antidepressants on Mitochondrial Energetics and Risk of Antidepressant Induced Mania
Resendez, Manuel Gardea, Coombes, Brandon, Veldic, Marin, Tye, Susannah, Romo-Nava, Francisco, Ozerdem, Aysegul, Prieto, Miguel, Cuellar-Barboza, Alfredo, Nunez, Nicolas, Miola, Alessandro, McElroy, Susan, Biernacka, Joanna, Morava, Eva, Kozicz, Tamas, and Frye, Mark (2025). Exploring the Role of Antidepressants on Mitochondrial Energetics and Risk of Antidepressant Induced Mania. The 27th Annual Conference of the International Society for Bipolar Disorders, Chiba, Japa, 17 – 19 September 2025. Hoboken, NJ, United States: Wiley-Blackwell Publishing.
Melatonin Mitigates IL-6-Induced Hyperdopaminergia, Oxidative Stress, and Metabolic Dysfunction: Implications for Dopaminergic Dysregulation in Bipolar Disorder
Macpherson, Heather, Varela, Roger, Daygon, Venea, Kesby, James, Cui, Xiaoying, and Tye, Susannah (2025). Melatonin Mitigates IL-6-Induced Hyperdopaminergia, Oxidative Stress, and Metabolic Dysfunction: Implications for Dopaminergic Dysregulation in Bipolar Disorder. The 27th Annual Conference of the International Society for Bipolar Disorders, Chiba, Japan, 17 – 19 September 2025. Hoboken, NJ, United States: Wiley-Blackwell Publishing.
Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male rats
Varela, Roger B., Macpherson, Heather, Walker, Adam J., Houghton, Tristan, Yates, Clarissa, Yates, Nathanael J., Daygon, Dara, and Tye, Susannah J. (2025). Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male rats. Brain, Behavior, and Immunity 127 170-182. https://doi.org/10.1016/j.bbi.2025.03.001
Inflammation in combination with metabolic deficits underly Anhedonia-like behavior in treatment resistant male rats
Varela, Roger, Macpherson, Heather, Houghton, Tristan, Yates, Clarissa, Yates, Nathanael, Daygon, Dara, and Tye, Susannah (2024). Inflammation in combination with metabolic deficits underly Anhedonia-like behavior in treatment resistant male rats. ACNP 63rd Annual Meeting: Poster Abstracts P609-P914, Phoenix, AZ United States, 8-11 December 2024. London, United Kingdom: Nature Publishing Group.