Queensland Brain Institute

Götz publications

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(as of April, 2023)

  • 220+ peer-reviewed articles (3 Cell, 1 Science, 1 Science Transl Med, 3 Neuron, 8 PNAS, 9 EMBO J, 7 J. Biol. Chem., 3 Mol Psych, 5 Acta Neuropathol, 1 Lancet, 4 Nature Rev Neurosci, 3 Nature Rev Neurol, 1 Nature Rev Drug Disc, 3 Nature Prot, 5 Theranostics)
  • Web of Science highly cited papers in the fields of Neuroscience & Behavior (5), Biology & Biochemistry, Pharmacology & Toxicology, and Molecular Biology & Genetics  
  • 27,700 citations (Google Scholar)
  • Total Impact factor: 2,000 
  • h-index: 86 (78 papers, >100 cit) (Google Scholar)
  • Expertscape ranking (Top 0.02% of 182, 647 published authors worldwide in Alzheimer's Disease)
  • Highly cited researcher 2022 (Clarivate)

Book chapters and other contributions

Nestor, Peter J., Pelekanos, Matthew, Leinenga, Gerhard, Song, Jae, Lee, Wendy, Richter-Stretton, Gina, McElligott, Caitlin, Fazlollahi, Amir, Mattingley, Jason B., Harris, Anthony, Beale, Henry, Roberts, Jennie, de las Heras, Rachel, and Götz, Jürgen (2025). A pilot safety and tolerability study of scanning ultrasound as a neuromodulation therapy in Alzheimer’s disease. Brain Communications 7 (6) fcaf445 fcaf445. https://doi.org/10.1093/braincomms/fcaf445

Götz, Jürgen (2025). Translational Research with FUS BBBO and Neuromodulation for AD. Alzheimer's Association International Conference (AAIC) 2025, Toronto, Canada, 27-31 July 2025. Hoboken, NJ United States: John Wiley & Sons.https://doi.org/10.1002/alz70859_103277

Song, Jae, Richter-Stretton, Gina, Pelekanos, Matthew, Clawson, Corbin, Saifzadeh, Siamak, Simon, Craig, Leinenga, Gerhard, de las Heras, Rachel, Alexander, Hamish, and Götz, Jürgen (2025). Feasibility of ultrasound-mediated blood–brain barrier opening in sheep using sonolucent cranial implants. Scientific Reports 15 (1) 41257 41257. https://doi.org/10.1038/s41598-025-25122-0

Lee, Jonathan L. F., Song, Jae, Amor, Rumelo, Bolton, Jonathon, Thompson, Andrew, Götz, Jürgen, and Padmanabhan, Pranesh (2025). High-resolution imaging reveals a cascade of interconnected cellular bioeffects differentiating the long-term fates of sonoporated cells. Journal of Controlled Release 385 113974 1-15. https://doi.org/10.1016/j.jconrel.2025.113974

Li, Yingjie, Qi, Wending, Chen, Le, Chu, Fan, Jiang, Wenfeng, Xu, Zifeng, Luo, Yuexin, Hu, Xubo, Götz, Jürgen, and Li, Chuanzhou (2025). Fyn-dependent Tau microcluster formation seeds and boosts extensive Tau pathology. Acta Neuropathologica 149 (1) 48 1-22. https://doi.org/10.1007/s00401-025-02887-2

Burgener, Sabrina Sofia, Milner, Mark Thomas, Dey, Shoumit, Morgan, Pooranee K., Blackmore, Daniel G., Frampton, Emmanuelle, Miller, Gregory, Duarte de Oliveira, Monalisa, Kenney, Kirsten Myra, Bajracharya, Rinie, Baumgartner, Ulrich, Collins, Thomas J. C., Xiong, Zherui, Nguyen, Quan, Meikle, Peter J., Bodea, Liviu-Gabriel, Clouston, Andrew, Boucher, Dave, Götz, Jurgen, Murphy, Andrew J., Kaye, Paul M., and Schroder, Kate (2025). Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases. BioRxiv . https://doi.org/10.1101/2025.04.28.651119

Leinenga, Gerhard, Padmanabhan, Pranesh, and Götz, Jürgen (2024). Improving cognition without clearing amyloid: effects of tau and ultrasound neuromodulation. Journal of Alzheimer's Disease 100 (s1) S211-S222. https://doi.org/10.3233/jad-240616

Cruz, Esteban, Nisbet, Rebecca M., Padmanabhan, Pranesh, van Waardenberg, Ashley J., Graham, Mark E, Nkajja, Godfrey, Tapaswi, Swara, Connor, Bradley J., Robinson, Phil, and Götz, Jürgen (2024). Proteostasis as a fundamental principle of Tau immunotherapy. Brain 148 (1) 168-184. https://doi.org/10.1093/brain/awae254

Leinenga, Gerhard, To, Xuan Vinh, Bodea, Liviu-Gabriel, Yousef, Jumana, Richter-Stretton, Gina, Palliyaguru, Tishila, Chicoteau, Antony, Dagley, Laura, Nasrallah, Fatima, and Götz, Jürgen (2024). Correction: Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction. Molecular Psychiatry 29 (12) 3968-3970. https://doi.org/10.1038/s41380-024-02616-3

Götz, Jürgen and Padmanabhan, Pranesh (2024). Ultrasound and antibodies — a potentially powerful combination for Alzheimer disease therapy. Nature Reviews Neurology 20 (5) 257-258. https://doi.org/10.1038/s41582-024-00943-1

Leinenga, Gerhard, To, Xuan Vinh, Bodea, Liviu-Gabriel, Yousef, Jumana, Richter-Stretton, Gina, Palliyaguru, Tishila, Chicoteau, Antony, Dagley, Laura, Nasrallah, Fatima, and Götz, Jürgen (2024). Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction. Molecular Psychiatry 29 (8) 1-16. https://doi.org/10.1038/s41380-024-02509-5

Padmanabhan, Pranesh, Kneynsberg, Andrew, Cruz, Esteban, Briner, Adam, and Götz, Jürgen (2024). Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells. Molecular Brain 17 (1) 7 7. https://doi.org/10.1186/s13041-024-01078-6

Leinenga, Gerhard, Richter-Stretton, Gina, To, Xuan Vinh, Chicoteau, Antony, Lee, Wendy, and Götz, Jürgen(2024). Scanning ultrasound-mediated improvements in APP23 mice. The University of Queensland. Data Collection.https://doi.org/10.48610/2ca0cbe

Leinenga, Gerhard, Richter-Stretton, Gina, To, Xuan Vinh, and Götz, Jürgen(2024). Scanning ultrasound-mediated improvements in APP23 mice in vivo imaging. The University of Queensland. Data Collection.https://doi.org/10.48610/0239687

Chen, Liyu, Song, Jae, Richter-Stretton, Gina, Lee, Wendy, Padmanabhan, Pranesh, and Götz, Jürgen (2024). Multimodal evaluation of blood-brain barrier opening in mice in response to low-intensity ultrasound and a claudin-5 binder. Nanotheranostics 8 (4) 427-441. https://doi.org/10.7150/ntno.95146

Wongsodirdjo, Patricia, Caruso, Alayna C., Vella, Laura J., Hung, Ya Hui, Götz, Jürgen, and Nisbet, Rebecca M. (2023). Neuronal targeting of tau using a mRNA‐encoded tau‐specific antibody fragment. Alzheimer’s Association International Conference AAIC 2023, Amsterdam, Netherlands, 16-20 July 2023. Hoboken, NJ United States: John Wiley & Sons.https://doi.org/10.1002/alz.082634

Ting, Ka Ka, Coleman, Paul, Kim, Hani Jieun, Zhao, Yang, Mulangala, Jocelyne, Cheng, Ngan Ching, Li, Wan, Gunatilake, Dilini, Johnstone, Daniel M., Loo, Lipin, Neely, G. Gregory, Yang, Pengyi, Götz, Jürgen, Vadas, Mathew A., and Gamble, Jennifer R. (2023). Vascular senescence and leak are features of the early breakdown of the blood–brain barrier in Alzheimer’s disease models. GeroScience 45 (6) 3307-3331. https://doi.org/10.1007/s11357-023-00927-x

Carlisle, Alison Keolani, Götz, Jürgen, and Bodea, Liviu-Gabriel (2023). Three methods for examining the de novo proteome of microglia using BONCAT bioorthogonal labeling and FUNCAT click chemistry. STAR Protocols 4 (3) 102418 102418. https://doi.org/10.1016/j.xpro.2023.102418

Cruz, Esteban, Nisbet, Rebecca M., and Götz, Jürgen (2023). Break and accelerator—The mechanics of Tau (and amyloid) toxicity. Cytoskeleton 81 (1) 24-29. https://doi.org/10.1002/cm.21781

Szabo, Leonora, Cummins, Nadia, Paganetti, Paolo, Odermatt, Alex, Papassotiropoulos, Andreas, Karch, Celeste, Götz, Jürgen, Eckert, Anne, and Grimm, Amandine (2023). ER‐mitochondria contacts and cholesterol metabolism are disrupted by disease‐associated tau protein. EMBO reports 24 (8) e57499 1-26. https://doi.org/10.15252/embr.202357499

Brandt, Roland and Götz, Jürgen (2023). Special issue on “Cytoskeletal proteins in health and neurodegenerative disease: Concepts and methods”. Brain Research Bulletin 198 50-52. https://doi.org/10.1016/j.brainresbull.2023.04.007

 

Padmanabhan, Pranesh and Götz, Jürgen (2023). Clinical relevance of animal models in aging-related dementia research. Nature Aging 3 (5) 481-493. https://doi.org/10.1038/s43587-023-00402-4

Leinenga, Gerhard, To, Xuan Vinh, Bodea, Liviu-Gabriel, Youse, Jumana, Richter-Stretton, Gina, Palliyaguru, Tishila, Chicoteau, Antony, Dagley, Laura, Nasrallah, Fatima, and Götz, Jürgen (2023). Scanning ultrasound-mediated memory and functional improvements do not require amyloid-β reduction.

Blackmore, Daniel G., Razansky, Daniel, and Götz, Jürgen (2023). Ultrasound as a versatile tool for short- and long-term improvement and monitoring of brain function. Neuron 111 (8) 1174-1190. https://doi.org/10.1016/j.neuron.2023.02.018

Taylor, Deonne, Kneynsberg, Andrew, van Roijen, Marloes, and Götz, Jürgen (2023). Tyrosine phosphatase STEP61 in human dementia and in animal models with amyloid and tau pathology. Molecular Brain 16 (1) 6 6. https://doi.org/10.1186/s13041-023-00994-3

Polanco, Juan Carlos, Akimov, Yevhen, Fernandes, Avinash, Briner, Adam, Hand, Gabriel Rhys, van Roijen, Marloes, Balistreri, Giuseppe and Götz, Jürgen (2022). CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau. Life Science Alliance, 6 (1), e202201689. [IF 5.781]

Martínez-Mármol, Ramón, Small, Christopher, Jiang, Anmin, Palliyaguru, Tishila, Wallis, Tristan P., Gormal, Rachel S., Sibarita, Jean-Baptiste, Götz, Jürgen and Meunier, Frédéric A. (2022). Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates. Molecular Psychiatry, 28 (2), 1-17. [IF 13.44]

Chen, Liyu, Cruz, Esteban, Oikari, Lotta E., Padmanabhan, Pranesh, Song, Jae and Götz, Jürgen (2022). Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound. Advanced Drug Delivery Reviews, 189 114517, 114517. [IF 15.47]

Bajracharya, Rinie, Cruz, Esteban, Götz, Jürgen and Nisbet, Rebecca M. (2022). Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy. Journal of Controlled Release, 349, 634-648. [IF 11.47]

Padmanabhan, Pranesh, Kneynsberg, Andrew, Cruz, Esteban, Amor, Rumelo, Sibarita, Jean‐Baptiste and Götz, Jürgen (2022). Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion. The EMBO Journal, 41 (19) e111265, 1-16. [IF 13.78]

Leinenga G, Bodea L-G, Schröder J, Sun GZ, Zhou Y, Song J, Grubman A, Polo JM*, Götz J* (2022) Disrupting the blood-brain barrier with scanning ultrasound leads to microglial activation and proliferation, Bioengineering & Translational Medicine (*shared author) (acc, April 5, 2022) [IF 10.711]

Milner MT, Lawrence G, Holley CL, Bodea L-G, Götz J, Burgener SS, Schroder K (2022) Isolation and culture of pure adult microglia and astrocytes for in vitro characterisation and analyses, STAR Protocols, 3:101295 [IF N.A.]

Chen L, Sutharsan E, Lee JLF, Cruz E, Asnicar B, Palliyaguru T, Wasielewska JM, Gaudin A, Song J, Leinenga G, Götz J (2022) Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model, Theranostics 12(5):1952-1970 [Back Cover image] [IF 11.556] (1 cit.)

Padmanabhan P, Kneynsberg A, Götz J (2021) Super-resolution microscopy: A closer look at Alzheimer disease, Nature Rev Neurosci 22: 723-740 [IF 33.162] (4 cit.)

Patents

9. Delivery of aducanumab to the brain by scanning ultrasound for the treatment of amyloid-beta neurodegenerative diseases, AU provisional 2019/904578 (Götz J, Leinenga G) 

8. (LTP) Acoustic energy treatment, AU provisional 2019/900632 (Götz J, Turpin F, Blackmore D)

7. Methods and compositions for treating tauopathies, PCT/AU2018/051129, filing date: 17.10.2018 (Götz J, Leinenga G, Nisbet R, Janowicz P)

6. Neurodegenerative disease treatment with focused ultrasound, WO/2015/192189, PCT/AU2015050345, international filing date: 19.06.2015, publication date: 23.12.2015, granted in AUS and the US (March 2022) (Götz J, Leinenga G)

5. Assay and method for identifying compounds that inhibit excitotoxic signals, US20150017657 A1, PCT/AU2012/001540, filing date: Dec 14, 2012, publication date: Jan 15, 2015 (L.M. Ittner, J. Götz)

4. Cell culture device and method, APPA2009904998, filing date: 13 Oct 2009 (lapsed) (L. Ittner, T. Fath, J. Götz, Y. Ke)

3. Treatments for excitotoxicity and Abeta-mediated toxicity and age-associated neuronal dysfunction, WO/2009/143556 (PCT/AU2009/000608), filing date: May 15, 2009, publication date: Dec 3, 2009 (J. Götz, L. Ittner)

2. A cellular assay system for neurofibrillary tangle formation, WO2004017072 A1 (PCT/EP2003/008983) filing date: 13 Aug, 2003, publication date 26 Feb, 2004 (J. Götz, R. Nitsch, A. Ferrari)

1. A method of inducing the formation of neurofibrillary tangles in transgenic animals, WO 03/017918 A2 (PCT/EP2002/009491), US 07550648, filing date: Aug 24, 2002, publication date: May 19, 2004 (J. Götz, R. Nitsch, F. Chen)