Does developmental myelination shape neural network formation?
Speaker: Dr Carlie Cullen
Leader of the Glial Neurobiology, Cognition and Behaviour Research Group
Mater Research
Honorary Senior Research Fellow
Menzies Institute for Medical Research, University of Tasmania
Does developmental myelination shape neural network formation?
Abstract: Myelination of the developing CNS is a highly coordinated and precisely timed process, yet we know very little about how this process influences neural network formation. Abnormal myelin content is a feature of many neurodevelopmental and neuropsychiatric disorders in which neural network function and information processing is also disturbed, though it is unclear which is cause or effect. We are seeking to untangle this by first, determining whether the onset of myelination helps shape the formation of functional neural networks in the developing brain. We have developed a zebrafish model of “delayed” developmental myelination and using whole brain calcium imaging, show that mistiming of myelination leads to subtle changes in neural network dynamics in the larval zebrafish brain.
About Neuroscience Seminars
Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.
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