Dr Lachlan Harris

QIMR Berghofer Medical Research Institute

300 Herston Road, Herston, QLD

Title: "Controlling stem cell quiescence for therapeutic gain in brain cancer"


Lachlan will discuss three stories of quiescent brain stem cells, in health and disease. Firstly, how stem cell quiescence deepens as a function of time, which prevents stem cells in the adult brain from activating and exhausting themselves prematurely. Secondly, he will discuss unpublished work highlighting how the transcription factor Ascl1 and a novel regulator of quiescence, Mycn, control distinct molecular programs and stages of stem cell activation. Finally, he will highlight his current work that focuses on the therapeutic potential of controlling stem cell quiescence in brain cancer. These studies include identifying how cancer stem cells in glioblastoma adopt a quiescent state to resist chemotherapy, and whether these cells can be eradicated by exploiting some of the unique cellular features of quiescence.


About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

Seminars in the QBI Auditorium on Level 7 are held on Wednesdays at 12-1pm, which are sometimes simulcast on Zoom (with approval from the speaker). We also occassionally hold seminars from international speakers via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details. 


Neuroscience Seminars archive 2005-2018