Professor Perry Bartlett was the inaugural Director of the Queensland Brain Institute and is a Professor of Molecular Neuroscience. Previously he was Head of of the Division of Development and Neurobiology at the Walter and Eliza Hall Institute of Medical Research. He has been responsible for a series of ground-breaking discoveries in neuroscience, which have often overturned existing dogma and led to a new understanding, particularly in the areas of neuronal precursor regulation and neuron survival in the developing and adult nervous system. Most prominent amongst these, was his laboratory's discovery in 1992 of the presence of stem cells in the adult brain that had the capacity to produce new neurons. His group was first to isolate and characterise these stem cells in 2001 and more recently revealed the presence of a latent hippocampal stem cell population that influences learning and memory.
Perry Bartlett is a Fellow of the Australian Academy of Science (FAA), a past NHMRC Senior Principal Research Fellow and ARC Federation Fellow and a past President of the Australian Neuroscience Society. He has championed interactions with China establishing three joint neuroscience laboratories, two with the Chinese Academy of Sciences and one with the Second Military Medical University, where he also holds an Honorary Professorship.
The adult brain has the ability to change, form new cells, and integrate these cells into the existing wiring. The brain continues to produce new neurons throughout life; however, the Bartlett laboratory has shown that the rate at which these new nerve cells are produced declines with age and may contribute to age-associated memory loss.
The group has also identified that latent stem cell populations exist within the adult brain, and these can be activated to give rise to new nerve cells. Within the hippocampus there exist subsets of cells that can be activated by different triggers. For example, experiences of learning and memory trigger one population, whereas anti-depressants trigger another. The presence of two, and perhaps more, distinct stem cell populations raises the possibility that the cells to which they give rise may also have different identities and therefore different capacities and functions. Research within the laboratory is focussed on the identification of these different cell populations, their functions, and their activating triggers. By understanding these fundamental processes, eventually, it may be possible to develop therapeutic products that delay, prevent or even reverse cognitive decline known to occur with advancing age. The Bartlett group also conducts research into spinal cord injury (SCI). The current key project involves the development of EphA4-Fc as a therapeutic for SCI.
- Professor Rongqiao He, QBI-IBP Joint Laboratory of Neuroscience and Cognition, with the Institute of Biophysics, Beijing, China.
- Professor Huji Xu, Joint Sino-Australian Neurogenetics Laboratory with the Second Military Medical University (SMMU), Shanghai, China. UQ collaborators include Matt Brown, Peter Visscher, Bryan Mowry, David Reutens.
- Dr Vidita Vaidya, Tata Institute of Fundamental Research, Mumbai, India.
- Professor Dongyuan Zhao, Fudan University, Shanghai, China. UQ collaborators include Max Lu, Gordon Xu and Helen Cooper.
- Professors Trevor Kilpatrick and Seong-Seng Tan, University of Melbourne. UQ collaborator Pankaj Sah.
- Professor Andrew Boyd, Queensland Institute of Medical Research.
Vukovic J, Borlikova GG, Ruitenberg MJ, Robinson G, Sullivan RKP, Walker TL, Bartlett PF. Immature doublecortin-positive hippocampal neurons are important for learning but not for remembering. J Neurosci 33:6603-6613, 2013
Blackmore DG, Vukovic J, Waters MJ, Bartlett PF. GH mediates exercise dependent activation of SVZ neural precursor cells in aged mice. PLoS ONE 7:e49912, 2012
Kameda M, Taylor CJ, Walker TL, Black DM, Abraham WC, Bartlett PF. Activation of latent precursors in the hippocampus is dependent on long-term potentiation. Transl Psychiatry 2:e72, 2012
Vukovic J, Colditz MJ, Blackmore DG, Ruitenberg MJ, Bartlett PF. Microglia modulate hippocampal neural precursor activity in response to exercise and aging. J Neurosci 32:6435-6443, 2012
Walker TL, Vukovic J, Koudijs MM, Blackmore DG, Mackay EW, Sykes AM, Overall RW, Hamlin AS, Bartlett PF. Prolactin stimulates precursor cells in the adult mouse hippocampus. PLoS ONE 7:e44371, 2012
Goldshmit Y, Spanevello MD, Tajouri S, Li L, Rogers F, Pearse M, Galea M, Bartlett PF, Boyd AW, Turnley AM. EphA4 blockers promote axonal regeneration and functional recovery following spinal cord injury in mice. PLoS ONE 6:e24636, 2011
Walker TL, Turnbull GW, Mackay EW, Hannan AJ, Bartlett PF. The latent stem cell population is retained in the hippocampus of transgenic Huntington’s disease mice but not wild-type mice. PLoS ONE 6:e18153, 2011
Beatus P, Jhaveri DJ, Walker TL, Lucas PG, Rietze RL, Cooper HM, Morikawa Y, Bartlett PF. Oncostatin M regulates neural precursor activity in the adult brain. Dev Neurobiol 71:619-633, 2011
Li L, Walker TL, Zhang Y, Mackay EW, Bartlett PF. Endogenous Interferon gamma directly regulates neural precursors in the non-inflammatory brain. J Neurosci 30:9038-9050, 2010
Jhaveri DJ, Mackay EW, Hamlin AS, Marathe SV, Nandam LS, Vaidya V, Bartlett PF. Norepinephrine directly activates adult hippocampal precursors via β3 adrenergic receptors. J Neurosci 30:2795-2806, 2010
Walker TL, White A, Black DM, Wallace RH, Sah P, Bartlett PF. Latent stem and progenitor cells in the hippocampus are activated by neural excitation. J Neurosci 28:5240-5247, 2008 (front cover)
Coulson EJ, May LM, Osborne S, Reid K, Underwood CK, Meunier FA, Bartlett PF, Sah P. p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4, 5-bisphosphate. J Neurosci 28:315-324, 2008
Young KM, Merson TD, Sotthibundhu A, Coulson EJ, Bartlett PF. p75 neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells. J Neurosci 27:5146-5155, 2007
Walker TL, Yasuda T, Adams DJ, Bartlett PF. The doublecortin-expressing population in the developing and adult brain contains multipotential precursors in addition to neuronal-lineage cells. J Neurosci 27:3734-3742, 2007
Merson TD, Rietze RL, Bartlett PF, Thomas T, Voss AK. The transcriptional co-activator Querkopf controls adult neurogenesis. J Neurosci 26:11359-11370, 2006
Bull ND, Bartlett PF. The adult mouse hippocampal progenitor is neurogenic but not a stem cell. J Neurosci 25:10815-10821, 2005 (front cover)
Goldshmit Y, Galea MP, Wise G, Bartlett PF, Turnley AM. Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice. J Neurosci 24:10064-10073, 2004
Forger NG, Prevette D, de Lapeyriere O, de Bovis B, Wang S, Bartlett P, Oppenheim RW. Cardiotrophin-like cytokine/cytokine-like factor 1 is an essential trophic factor for lumbar and facial motoneurons in vivo. J Neurosci 23:8854-8858, 2003
Turnley AM, Faux CH, Rietze RL, Coonan JR, Bartlett PF. Suppressor of cytokine signaling 2 regulates neuronal differentiation by inhibiting growth hormone signaling. Nature Neuroscience 5:1155-1162, 2002
Butzkueven H, Zhang J-G, Soilu-Hänninen M, Hochrein H, Chionh F, Shipham KA, Emery B, Turnley AM, Petratos S, Ernst M, Bartlett PF, Kilpatrick TJ. LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival. Nature Med 8:613-619, 2002
Rietze RL, Valcanis H, Brooker GF, Thomas T, Voss AK, Bartlett PF. Purification of a pluripotent neural stem cell from the adult mouse brain. Nature 412:736-739, 2001 (front cover)
Faux CH, Turnley AM, Epa R, Cappai R, Bartlett PF. Interactions between fibroblast growth factors and Notch regulate neuronal differentiation. J Neurosci 21:5587-5596, 2001
Coonan JR, Greferath U, Messenger J, Hartley L, Murphy M, Boyd AW, Dottori M, Galea MP, Bartlett PF. The development and reorganization of corticospinal projections in EphA4 deficient mice. J Comp Neurol 436:248-262, 2001