GWAS analyses in Indian and Sarawak populations, comparing the results with the latest results for European-ancestry schizophrenia from the Psychiatric Genomics Consortium.
Phase 2 Indian schizophrenia GWAS using additional samples from India and UK Biobank.
Targeted resequencing analyses of a previously identified chromosomal region in an Indian sample.
Identification of de novo and transmitted mutations using whole exome sequence data from Indian family based schizophrenia cohort.
Functional characterisation of top Indian GWAS locus in zebrafish and cellular models.
Investigation of top Indian locus in NAD pathway using Indian plasma samples.
In silico Investigation of the impact of schizophrenia GWAS loci during human brain development using spatio-temporal brain gene expression data.
Using deep learning to predict disease mechanisms from GWAS in psychiatric disorders.
Developing deep learning models to predict differential binding of regulators in schizophrenia-associated loci.
Generating disease specific genetic interaction data investigate relationships between genotype and phenotype using genome-wide GWAS data.
Investigating the normal and pathogenic in vivo role of genes recently associated with brain disorders and schizophrenia in particular, using the zebrafish as research model (PhD Projects available)
Identifying new neuroactive drugs using national and international chemical libraries and the zebrafish as a screening tool (PhD Projects available).
Understanding the cellular and molecular effect of current anti-psychotic drugs using the zebrafish and state-of-the-art microscopy technologies (PhD Projects available).
