Dr Rebecca Nisbet
Reseach Fellow
Clem Jones Centre for Ageing Dementia Research
+61 7 334 66326
Book Chapter
Nisbet, Rebecca M. and Gotz, Jurgen (2018). Amyloid-β and tau in Alzheimer's disease: novel pathomechanisms and non-pharmacological treatment strategies. In Perry, G., Avila, J., Moreira, P.I., Sorensen, A.A. and Tabaton, M. (Ed.), Alzheimer's Disease: New Beginnings (pp. 515-525) Amsterdam, Netherlands: IOS Press. doi:10.3233/978-1-61499-876-1-515
Journal Articles
Janowicz, Phillip W., Leinenga, Gerhard, Götz, Jürgen and Nisbet, Rebecca M. (2019) Ultrasound-mediated blood-brain barrier opening enhances delivery of therapeutically relevant formats of a tau-specific antibody. Scientific Reports, 9 1: 9255. doi:10.1038/s41598-019-45577-2
Götz, Jürgen, Halliday, Glenda and Nisbet, Rebecca M. (2019) Molecular pathogenesis of the tauopathies. Annual Review of Pathology: Mechanisms of Disease, 14 239-261. doi:10.1146/annurev-pathmechdis-012418-012936
Nisbet, Rebecca M. and Götz, Jürgen (2018) Amyloid-β and Tau in Alzheimer's Disease: Novel Pathomechanisms and Non-Pharmacological Treatment Strategies. Journal of Alzheimer's Disease, 64 s1: S517-S527. doi:10.3233/JAD-179907
Brici, David, Götz, Jürgen and Nisbet, Rebecca M. (2018) A Novel Antibody Targeting Tau Phosphorylated at Serine 235 Detects Neurofibrillary Tangles. Journal of Alzheimer's Disease : JAD, 61 3: 899-905. doi:10.3233/JAD-170610
Leinenga, Gerhard, Nisbet, Rebecca M. and Gotz, Jurgen (2017) Ultrasound as a treatment modality for neurological diseases. Medical Journal of Australia, 206 11: 470-471. doi:10.5694/mja16.01013
Nisbet, Rebecca M., Van der Jeugd, Ann, Leinenga, Gerhard, Evans, Harrison T., Janowicz, Phillip W. and Goetz, Juergen (2017) Combined effects of scanning ultrasound and a tau-specific single chain antibody in a tau transgenic mouse model. Brain, 140 5: 1220-1230. doi:10.1093/brain/awx052
Liu, Chang, Song, Xiaomin, Nisbet, Rebecca and Goetz, Juergen (2016) Co-immunoprecipitation with Tau isoform-specific antibodies reveals distinct protein interactions and highlights a putative role for 2N Tau in disease. Journal of Biological Chemistry, 291 15: 8173-8188. doi:10.1074/jbc.M115.641902
Leinenga, Gerhard, Langton, Christian, Nisbet, Rebecca and Gotz, Jurgen (2016) Ultrasound treatment of neurological diseases — current and emerging applications. Nature Reviews Neurology, 12 3: 161-174. doi:10.1038/nrneurol.2016.13
Nisbet, Rebecca M., Polanco, Juan-Carlos, Ittner, Lars M. and Gotz, Jurgen (2014) Tau aggregation and its interplay with amyloid-β. Acta Neuropathologica, 129 2: 207-220. doi:10.1007/s00401-014-1371-2
Baer, Samuel, Nigro, Julie, Madej, Mariusz P., Nisbet, Rebecca M., Suryadinata, Randy, Coia, Gregory, Hong, Lisa P. T., Adams, Timothy E., Williams, Charlotte C. and Nuttall, Stewart D. (2014) Comparison of alternative nucleophiles for Sortase A-mediated bioconjugation and application in neuronal cell labelling. Organic and Biomolecular Chemistry, 12 17: 2675-2685. doi:10.1039/c3ob42325e
Nisbet, R. M., Nigro, J., Breheney, K., Caine, J., Hattarki, M. K. and Nuttall, S. D. (2013) Central amyloid-beta-specific single chain variable fragment ameliorates A-beta aggregation and neurotoxicity. Protein Engineering Design and Selection, 26 10: 571-580. doi:10.1093/protein/gzt025
Nisbet, Rebecca M., Nuttall, Stewart D., Robert, Remy, Caine, Joanne M., Dolezal, Olan, Hattarki, Meghan, Pearce, Lesley A., Davydova, Natalia, Masters, Colin L., Varghese, Jose N. and Streltsov, Victor A. (2013) Structural studies of the tethered N-terminus of the Alzheimer's disease amyloid-beta peptide. Proteins, 81 10: 1748-1758. doi:10.1002/prot.24312
Eckert, Anne, Nisbet, Rebecca, Grimm, Amandine and Götz, Jürgen (2013) March separate, strike together: role of phosphorylated TAU in mitochondrial dysfunction in Alzheimer's disease. Biochimica et Biophysica Acta (BBA): Molecular Basis of Disease, 1842 8: 1258-1266. doi:10.1016/j.bbadis.2013.08.013
Madej, Mariusz P., Coia, Gregory, Williams, Charlotte C., Caine, Joanne M., Pearce, Lesley A., Attwood, Rebecca, Bartone, Nick A., Dolezal, Olan, Nisbet, Rebecca M., Nuttall, Stewart D. and Adams, Timothy E. (2012) Engineering of an anti-epidermal growth factor receptor antibody to single chain format and labeling by sortase A-mediated protein ligation. Biotechnology and Bioengineering, 109 6: 1461-1470. doi:10.1002/bit.24407
Nisbet, Rebecca M., Harrison, Christopher F., Lawson. Victoria A., Masters, Colin L., Cappai, Roberto and Hill, Andrew F. (2010) Residues surrounding the glycosylphosphatidylinositol anchor attachment site of PrP modulate prion infection: insight from the resistance of rabbits to prion disease. Journal of Virology, 84 13: 6678-6686. doi:10.1128/JVI.02709-09
Ramdzan, Yasmin M., Nisbet, Rebecca M., Miller, Jason, Finkbeiner, Steven, Hill, Andrew F. and Hatters, Danny M. (2010) Conformation sensors that distinguish monomeric proteins from oligomers in live cells. Chemistry and Biology, 17 4: 371-379. doi:10.1016/j.chembiol.2010.03.011
Coleman, Bradley M., Nisbet, Rebecca M., Han, Sen, Cappai, Roberto, Hatters, Danny M. and Hill, Andrew F. (2009) Conformational detection of prion protein with biarsenical labeling and FIAsH fluorescence. Biochemical and Biophysical Research Communications, 380 3: 564-568. doi:10.1016/j.bbrc.2009.01.120
Sharples, Robyn A., Vella, Laura J., Nisbet, Rebecca M., Naylor, Ryan, Perez, Keyla, Barnham, Kevin J., Masters, Colin L. and Hill, Andrew F (2008) Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes. The Faseb Journal, 22 5: 1469-1478. doi:10.1096/fj.07-9357com
Vella, Laura J., Sharples, Robyn A., Nisbet, Rebecca M., Cappai, Roberto and Hill, Andrew F. (2008) The role of exosomes in the processing of proteins associated with neurodegenerative diseases. European Biophysics Journal, 37 3: 323-332. doi:10.1007/s00249-007-0246-z
Conference Papers
Götz, Jürgen, Nisbet, Rebecca, Van der Jeugd, Ann, Evans, Harrison and Leinenga, Gerhard (2016). Scanning ultrasound as a treatment tool of proteinopathies including Alzheimer’s disease. In: 5th International Symposium on Focused Ultrasound, Bethesda, MD, USA, (4-4). 28 August - 1 September 2016. doi:10.1186/s40349-016-0076-5
Leinenga, Gerhard, Nisbet, Rebecca, Hatch, Robert, Van der Jeugd, Anneke, Evans, Harrison and Götz, Jürgen (2016). Scanning Focused Ultrasound disruption of the blood-brain barrier as an Alzheimer’s disease therapy. In: 5th International Symposium on Focused Ultrasound, Bethesda, MD, USA, (3-3). 28 August - 1 September 2016. doi:10.1186/s40349-016-0076-5
Goetz, J., Nisbet, R., Leinenga, G. and Van der Jeugd, A. (2015). Novel strategies to target tau and Ab toxicity. In: Special Issue: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian Pacific Society for Neurochemistry in Conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD Australia, (90-90). 23-27 August 2015. doi:10.1111/jnc.13186
Van der Jeugd, A., Leinenga, G., Nisbet, R. and Goetz, J. (2015). Scanning ultrasound opens blood-brain barrier and improves pathologic abnormalities and behaviour in a mouse model of Alzheimer's. In: 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society. 25th Biennial Meeting of the International Society for Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, QLD, Australia, (277-278). 23 - 27 August 2015.