Dr Lei Qian
Postdoctoral Research Fellow
School of Biomedical Sciences
Affiliate Research Fellow
Queensland Brain Institute
+61 7 336 52397
Journal Articles
Martínez-Mármol, Ramón, Mohannak, Nika, Qian, Lei, Wang, Tong, Gormal, Rachel S, Ruitenberg, Marc J, Vanhaesebroeck, Bart, Coulson, Elizabeth J and Meunier, Frédéric A (2019) p110δ PI 3-kinase inhibition perturbs APP and TNFα trafficking, reduces plaque burden, dampens neuroinflammation and prevents cognitive decline in an Alzheimer's disease mouse model. The Journal of Neuroscience, . doi:10.1523/JNEUROSCI.0674-19.2019
Milne, Michael R., Qian, Lei, Turnbull, Marion T., Kinna, Genevieve, Collins, Brett M., Teasdale, Rohan D. and Coulson, Elizabeth J. (2019) Downregulation of SNX27 expression does not exacerbate amyloidogenesis in the APP/PS1 Alzheimer's disease mouse model. Neurobiology of Aging, 77 144-153. doi:10.1016/j.neurobiolaging.2019.01.011
Boskovic, Zoran, Milne, Michael R., Qian, Lei, Clifton, Hamish D., McGovern, Alice E., Turnbull, Marion T., Mazzone, Stuart B. and Coulson, Elizabeth J. (2018) Cholinergic basal forebrain neurons regulate fear extinction consolidation through p75 neurotrophin receptor signaling. Translational Psychiatry, 8 1: 199. doi:10.1038/s41398-018-0248-x
Qian, Lei, Milne, Michael R., Shepheard, Stephanie, Rogers, Mary-Louise, Medeiros, Rodrigo and Coulson, Elizabeth J. (2018) Removal of p75 neurotrophin receptor expression from cholinergic basal forebrain neurons reduces amyloid-β plaque deposition and cognitive impairment in aged APP/PS1 mice. Molecular Neurobiology, . doi:10.1007/s12035-018-1404-2
Guo, Wenjing, Qian, Lei, Zhang, Jing, Zhang, Wei, Morrison, Alastair, Hayes, Philip, Wilson, Steve, Chen, Tongsheng and Zhao, Jie (2011) Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling. Journal of Neuroscience Research, 89 11: 1723-1736. doi:10.1002/jnr.22725
Wang, Jia, Ruan, Nan-Jie, Qian, Lei, Lei, Wen-Liang, Chen, Fei and Luo, Zhen-Ge (2008) Wnt/beta-catenin signaling suppresses Rapsyn expression and inhibits acetylcholine receptor clustering at the neuromuscular junction. Journal of Biological Chemistry, 283 31: 21668-21675. doi:10.1074/jbc.M709939200
Zhang, Xian, Zhu, Ji, Yang, Guo-Ying, Wang, Qing-Jie, Qian, Lei, Chen, Yan-Min, Chen, Fei, Tao, Yu, Hu, Han-Song, Wang, Tong and Luo, Zhen-Ge (2007) Dishevelled promotes axon differentiation by regulating atypical protein kinase C. Nature Cell Biology, 9 7: 743-U27. doi:10.1038/ncb1603
Chen, F, Qian, L, Yang, ZH, Huang, Y, Ngo, ST, Ruan, NJ, Wang, J, Schneider, C, Noakes, PG, Ding, YQ, Mei, L and Luo, ZG (2007) Rapsyn interaction with calpain stabilizes AChR clusters at the neuromuscular junction. Neuron, 55 2: 247-260. doi:10.1016/j.neuron.2007.06.031
Conference Papers
Qian, L., Marks, N., Sharma, A., Bellingham, M. and Coulson, E. (2015). Cholinergic dysfunction of mesopontine tegmentum is involved in the development of Alzheimer's disease. In: 25th Biennial Meeting of the International-Society-for-Neurochemistry Jointly with the 13th Meeting of the Asian-Pacific-Society-for-Neurochemistry in Conjunction with the 35th Meeting of the Australasian-Neuroscience-Society, Cairns, QLD, Australia, (343-343). 23-27 August 2015. doi:10.1111/jnc.13189
Camara, M. Iou, Matusica, D., Qian, L., Bredy, T., Nykjaer, A. and Coulson, E. (2015). Enhancing TRK mediated trophic signalling to augment cognitive processes. In: 25th Biennial Meeting of the International Society for Neurochemistry jointly with the 13th Meeting of the Asian‐Pacific Society for Neurochemistry in conjunction with the 35th Meeting of the Australasian Neuroscience Society, Cairns, QLD, Australia, (322-322). 23-27 August 2015. doi:10.1111/jnc.13189
Chen, Fei, Qian, Lei, Yang, Zhi-hua, Huang, Ying, Ngo, Shyuan T., Ruan, Nan-jie, Wang, Jia, Schneider, Claudio, Noakes, Peter G., Ding, Yu-qiang, Mei, Lin and Luo, Zhen-ge (2007). Signaling underlying postsynaptic differentiation at the neuro-muscular junction. In: The 19th Federation of Asian and Oceanian Biochemists and Molecular Biologists Inc. (FAOBMB) Meeting, Seoul, Korea, (). 27-31 May, 2007.