Professor Giampietro Schiavo
Department of Neuromuscular Diseases, UCL, UK

Title: "The role of axonal transport disfunction and motor complex mutations in neurodegenerative diseases"


Axonal transport is critical for maintaining neuronal homeostasis, function and survival through bi-directional trafficking of essential complexes and organelles between proximal and distal compartments of neurons. Deficits in axonal transport have been detected both in vitro and in vivo in several models of neurodegenerative disease, such as amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD) and peripheral neuropathies. Importantly, impairments in this process have been shown pre-symptomatically, suggesting that deficits in axonal transport are causative to disease. However, our understanding of the underlying mechanisms remains unclear.
In this lecture, I will present data supporting the hypothesis that motor neurons innervating muscles with different fibre-type compositions have distinct axonal transport features, which change through disease, thus contributing to ALS pathogenesis. Furthermore, I will provide evidence  that modulation of axonal transport represents a new therapeutic strategy in ALS and other neurodegenerative diseases.
Keywords: Axonal transport, neurotrophic factors, neurodegenerative disease


About Neuroscience Seminars

Neuroscience seminars at the QBI play a major role in the advancement of neuroscience in the Asia-Pacific region. The primary goal of these seminars is to promote excellence in neuroscience through the exchange of ideas, establishing new collaborations and augmenting partnerships already in place.

While seminars in the QBI Auditorium have been suspended due to COVID-19, we will still be holding seminars via Zoom. The days and times of these seminars will vary depending on the time zone of the speaker. Please see each seminar listed below for details. 


Neuroscience Seminars archive 2005-2018